Cancer Metabolism and Signaling Networks Program

intestinal epithelia

Adaptive strategies

As tumors rapidly develop, they outgrow their blood supply and the stores of nutrients and growth-stimulating metabolites they need to survive. 

To satisfy their needs, cancer cells reprogram their metabolism, remodel their surroundings, recruit non-malignant cells and even provide aid to each other—engaging in “cross-talk” to help expand their population. Tumors use the same adaptive strategies to resist chemotherapy, targeted therapy and to suppress the immune system.

Program statement

We are studying the metabolic and signaling pathways that support tumor growth metastasis, drug resistance and immune suppression. We make significant efforts to build dialogue with clinicians and physician scientists across the country and in neighboring institutions to ensure the translational and human relevance of our research. As our knowledge of the adaptive strategies tumors use to survive increases, so does the number of molecules and pathways we can potentially target for cancer treatment.



Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor.

Huang J, Duran A, Reina-Campos M, Valencia T, Castilla EA, Müller TD, Tschöp MH, Moscat J, Diaz-Meco MT

Cancer Cell 2018 Apr 9 ;33(4):770-784.e6

Lipoprotein Particle Formation by Proapoptotic tBid.

Ekanayake V, Nisan D, Ryzhov P, Yao Y, Marassi FM

Biophys J 2018 Aug 7 ;115(3):533-542

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.

Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, Divecha N, Asara JM, Elemento O, Rubin MA, Kimmelman AC, Pause A, Cantley LC, Emerling BM

Mol Cell 2018 May 3 ;70(3):531-544.e9

ORP5 regulates PI(4)P on the lipid droplet: Novel players on the monolayer.

Renne MF, Emerling BM

J Cell Biol 2020 Jan 6 ;219(1)

Serrated Colorectal Cancer: The Road Less Travelled?

Nakanishi Y, Diaz-Meco MT, Moscat J

Trends Cancer 2019 Nov ;5(11):742-754

Phosphoinositides in autophagy: current roles and future insights.

Palamiuc L, Ravi A, Emerling BM

FEBS J 2020 Jan ;287(2):222-238

The complexity of the serine glycine one-carbon pathway in cancer.

Reina-Campos M, Diaz-Meco MT, Moscat J

J Cell Biol 2020 Jan 6 ;219(1)

The Dual Roles of the Atypical Protein Kinase Cs in Cancer.

Reina-Campos M, Diaz-Meco MT, Moscat J

Cancer Cell 2019 Sep 16 ;36(3):218-235

Polyploidy spectrum: a new marker in HCC classification.

Bou-Nader M, Caruso S, Donne R, Celton-Morizur S, Calderaro J, Gentric G, Cadoux M, L'Hermitte A, Klein C, Guilbert T, Albuquerque M, Couchy G, Paradis V, Couty JP, Zucman-Rossi J, Desdouets C

Gut 2020 Feb ;69(2):355-364

Show All Publications