Events Archives - Sanford Burnham Prebys
Institute News

“Chalk talks” foster community among San Diego stem cell researchers

AuthorJessica Moore
Date

January 18, 2017

Many scientists in San Diego, and particularly on the Torrey Pines mesa, are working on therapies that rely on stem cell biology—modeling diseases for drug discovery, trying to understand the basis of a disease to develop gene therapies, or deriving transplant-based treatments. To Evan Snyder, MD, PhD, director of the Center for Stem Cells and Regenerative Medicine at Sanford Burnham Prebys Medical Discovery Institute (SBP), the local concentration of academic, clinical and industry research in this promising field creates an opportunity to encourage new collaborations.

“I wanted to get together those from multiple spheres in a way that would promote conversation,” says Snyder. “I had heard from both basic scientists and clinicians that they wanted to interact more with one another. And everyone wants to make connections with people from industry, since their work is what gets new treatments to patients. At our center retreat last year, the idea to have ‘chalk talk’ happy hours arose—instead of the usual seminar series where attendees sit and listen, this format allows attendees to interact before, during and after the presentations.”

“Chalk talks” are a way of presenting research that doesn’t rely on PowerPoint slides, creating an atmosphere that encourages audience participation and dialogue. To explain ideas visually, speakers draw on a board, the way it was done before personal computers and projectors became common.

“We also have research teams present together,” adds Snyder. “That way, you get to meet multiple people from a lab, not just the principal investigator. This approach also helps with getting collaborations started, because trainees might be more likely to approach fellow postdocs or students than they would a professor or lead scientist.”

The get-togethers, which have become well known among clinicians on the Mesa, are held the second Thursday of every month from 4-6 pm in Chairmen’s Hall and are open to all scientists and staff at the Institute. This month’s talk, on January 12, was given by the lab of Anders Persson, PhD, at UC San Francisco, who were visiting the Snyder lab. The topic, “Stem Cells in the Adult Cortex: Fact or Fiction,” sparked a lively discussion on the ability of the fully-formed brain to generate new neurons and how that relates to adult brain cancers. 

Institute News

Cancer Moonshot satellite summit held at Sanford Burnham Prebys

AuthorJessica Moore
Date

July 7, 2016

Our institute was one of ten sites in the U.S. selected to co-host an official summit as part of the kick-off for Vice President Joe Biden’s Cancer Moonshot. This $1 billion initiative “aims to make more therapies available to more patients, while also improving our ability to prevent cancer and detect it at an early stage.” The funds support new cancer research programs within the NIH and the Departments of Defense and Veterans Affairs, as well as data sharing infrastructure and efforts by the FDA to expedite development of new cancer drugs and diagnostics.

The SBP event, held on the same day as the Vice President’s summit in Washington, DC, brought together oncologists, cancer researchers, cancer survivors and their families, developers of cancer therapeutics, and leaders of key institutions making an impact on cancer in southern California. This diverse participation provided opportunities to make connections, get inspired, and find potential collaborators.

The program included an explanation of how scientific leaders are shaping the initiative, a videocast of the vice president’s speech, and three panel discussions of hopes and concerns for the program. The inside take on the Moonshot’s development was given by María Elena Martínez, PhD, professor of Family Medicine and Public Health at the UC San Diego Moores Cancer Center, one of 30 experts on the Blue Ribbon Panel that is developing recommendations for action.

Several messages emerged from SBP’s summit, including:

  • Sustained research funding is required to ensure significant progress
  • Improving clinical trials (enhancing participation and streamlining approvals) is key to accelerate the pace of drug development
  • Data sharing systems must be built up to reap maximum benefits from cutting-edge methods of profiling tumors

The event was covered by multiple local news outlets, including KPBS and KUSI, and livestreamed through Facebook (video available here and here).

Garth Powis, D.Phil., director of the NCI-designated Cancer Center at SBP, was called to take part in the summit in Washington, DC.

“It was worthwhile to be there and see how the White House is interacting with the NCI,” Powis said. “Much of the focus was on big data. GSK is working with the Department of Energy to get the Veterans Administration organized and IBM is using their super computer ‘Watson’ to consolidate patient records.”

The Moonshot promises to accelerate cancer research in San Diego, given its position as a major hub for biomedical science, though no funds have yet been distributed.

 

Institute News

Happy 40th, Sanford Burnham Prebys!

AuthorJessica Moore
Date

July 7, 2016

Today marks the 40th anniversary of our institute, which was founded on July 7, 1976 as the La Jolla Cancer Research Foundation. The institute that Dr. William and Lillian Fishman started in a renovated apartment building with equipment built from spare parts has since become ;a world-renowned research organization. The original staff of five has now grown to over 1,000 employees, including more than 700 scientists.

The City of San Diego has declared today, July 7, 2016 “Sanford Burnham Prebys Medical Discovery Institute Day.” Mayor Faulconer’s Director of Outreach, John Ly, came to SBP to deliver the proclamation, which highlights 40 years of scientific successes.

SBP will continue to celebrate its 40 years of success with various events over the next 12 months.

 

 

Institute News

2016 Faculty Retreat highlights research advances, awards and promotions

AuthorSusan Gammon
Date

May 20, 2016

The 2016 Faculty Retreat, held May 11-12, attracted more than 70 SBP scientists wanting to learn more about their colleagues’ latest discoveries, explore collaborations and socialize in beautiful Carlsbad, Calif.

The two-day event included seven sessions covering the scientific themes and disease areas on which much of the Institute’s research is focused:

Metabolism—Chair: Timothy Osborne Epigenetics—Chair: Robert Wechsler-Reya Proteostasis—Chair: Rolf Bodmer Cancer—Chair: Garth Powis Neurological Disorders—Chair: Barbara Ranscht Immunomodulation—Chair: Carl Ware Metabolic Disorders—Chair: Sheila Collins

Special kudos to Duc Dong, PhD, for receiving this year’s “WOW” award. Dong, an assistant professor in the Human Genetics Program, presented his novel approach to generating insulin-producing beta cells to treat diabetes. The talk, titled, “Replacement of beta cells by direct in vivo trans-differentiation,” explained his work using zebrafish as a disease model to uncover ways to reprogram non-pancreatic cells within a living vertebrate to become beta cells. “WOW” stands for Wonderful Original Work and is an SBP Faculty Retreat tradition awarded by vote.

Congratulations to Julio Ayala, PhD, who was officially promoted at the retreat to associate professor in the Integrative Metabolism Program. Read more about Ayala’s efforts to advance treatments for diabetes here.

The keynote presentation was given by David Brenner, MD, vice chancellor of Health Sciences and dean of its School of Medicine at UC San Diego. Brenner’s presentation, “Fibrosis: The final common pathway in chronic injury,” gave SBP scientists a clinical perspective on cutting-edge research in prevention, causes and future treatments for fibrosis associated with liver disease.

The retreat was organized by Lazlo Nagy, MD, PhD, professor and director of the Genomic Control of Metabolism Program and Bas Baaten, PhD, assistant professor in the Immunity and Pathogenesis Program.

And it couldn’t have happened without the superb support from Esther Minotti, research administrative specialist who coordinated the show.

Institute News

SBP’s Lake Nona campus to host metabolomics symposium

AuthorJessica Moore
Date

April 29, 2016

The annual Southeast Center for Integrated Metabolomics (SECIM) symposium will be held at SBP’s Lake Nona Campus next week (May 3-4). SECIM, a collaboration between SBP and the University of Florida, is one of six federally funded centers that provide cutting-edge metabolite fingerprinting capabilities to the research community. Metabolites are small molecules in the body that populate the complex web of metabolic pathways. Metabolomics is a relatively new field that uses sophisticated technologies to detect hundreds to thousands of metabolites in biological samples. A metabolite profile can serve as a signature of health, disease or drug action. Continue reading “SBP’s Lake Nona campus to host metabolomics symposium”

Institute News

A bunch of scientists walk into a brewery…

Authorkcusato
Date

April 7, 2016

A bunch of scientists walk into a brewery…

It sounds like the beginning of a joke, and there were plenty of smiles at the Karl Strauss Brewery in downtown San Diego on April 5th, but they were on the faces of the people there to see science and art come together, as part of a BioArt exhibit. Continue reading “A bunch of scientists walk into a brewery…”

Institute News

Symposium brings leaders in tumor immunology to SBP

Authorjmoore
Date

March 21, 2016

SBP’s La Jolla campus recently hosted a one-day conference on Cancer Immunology and the Tumor Microenvironment, one of the hottest topics in cancer research. The symposium on March 17 attracted approximately 160 attendees from across the La Jolla biomedical research mesa.

The symposium was organized by Carl Ware, PhD and Robert Rickert, PhD, directors of the Inflammatory and Infectious Disease Center and the Tumor Microenvironment and Cancer Immunology Program, respectively. They planned a scientific agenda that covered diverse aspects of research on harnessing the immune system to treat cancer, from improving current immunotherapies to identifying new immunological targets. Talks were given by prestigious scientists including:

Two SBP researchers also presented. Linda Bradley, PhD, professor in the Immunity and Pathogenesis Program, discussed her work on the immune cell surface protein PSGL-1, showing that it regulates PD-1, a so-called “immune checkpoint.” PD-1 is found on T cells and normally acts as on “off switch” to keep the immune system from attacking cells in the body. PD-1 regulators are a new approach to treating cancer that work by unleashing cytotoxic T cells to kill cancer cells.

 

Adam Godzik, PhD, professor and director of the Bioinformatics and Structural Biology Program, spoke about using bioinformatic analyses to search for new cancer drivers related to the immune response. Cancer drivers are genes that, when altered, are responsible for cancer progression. Combining cancer mutation and protein structure databases, his team has identified many genes involved in immune recognition of tumors.

Institute News

SBP scientists join race for a cure

Authordrobison
Date

March 17, 2016

Andrew Carley, PhD, has a personal motivation for finding a cure for diabetes. As one of the 29 million Americans with diabetes, he became a biomedical researcher to better understand the causes of disease.

For Julio Ayala, PhD, a passion for medical research was sparked by his grandmother, a type 1 diabetic, who at age 86 has successfully managed the disease most of her life.

Julio Ayala, PhD
Julio Ayala, PhD

Siobhan Malany, PhD, is an avid cyclist who believes so strongly in team efforts that she has enlisted robots to join her research team searching for new drugs to fight disease.

On Sunday, March 13, 2016, these Sanford Burnham Prebys scientists took their interest in biomedical research to the roadways of Central Florida as they joined 1,100 participants in the 2016 Tour de Cure at Lake Nona bicycle ride for diabetes. The twelve-member SBP team collectively pedaled more than 400 miles and raised $9,000 to fight the disease. Participants began the 25, 63, and 100-mile courses in Lake Nona Medical City near SBP and the Center for Metabolic Origins of Disease, the site where researchers study diabetes in hopes of identifying new, more effective therapies.

“It was a fun way to give back and do what I love to do.  Cycling has been my commute, my sport and my escape —now it’s a way to contribute,” said Malany, who completed the 100-mile course in five hours. She enjoyed the camaraderie and credited the group with a bit of competitive motivation. “I kept a 21.5 mile per hour pace, which was not something I would have accomplished had I been cycling alone. It was fast and fun being in a pack because you conserve energy by drafting,” added Malany.

Siobhan Malany, PhD
Siobhan Malany, PhD

Since moving to Lake Nona in December from Chicago, Carley has gotten back into cycling and now bikes to the Institute in Medical City each day. He completed a Century ride to mark the 20th anniversary of the Tour de Cure in 2011 in Chicago and decided to mark the 25th anniversary of the event with a 25 mile ride. “I selected the 25 mile course because it was the maximum length of time my 3-year old daughter would remain content in her bike stroller watching a Toy Story movie. She weighs only 32 pounds and the course was relatively flat so we were able to complete the ride in two hours despite frequent stops,” said Carley.

Tour-de-cure

Team captain Ayala participated in various ADA and JDRF fund raising events while at Vanderbilt University. “While riding my bike to work a few years ago, I saw the first Tour de Cure in Lake Nona and knew that I wanted to participate. We study diseases of metabolism at the Medical City site and a number of faculty, including me, receive ADA-funded grants, so I wanted to get involved,” said Ayala.

Ayala credits the team’s spirit with providing extra motivation to push through the extreme winds encountered on the course. It’s with similar determination that they approach their daily race for the cure in their research labs.

Institute News

Upcoming symposium: Cancer Immunology and the Tumor Microenvironment

Authorjmoore
Date

March 10, 2016

On March 17, SBP La Jolla is hosting a symposium on the interactions between the immune system and tumors, including how they can be leveraged for cancer treatment. The symposium is organized by Carl Ware, PhD and Robert Rickert, PhD, the directors of the Inflammatory and Infectious Disease Center and the Tumor Microenvironment and Cancer Immunology Program, respectively, and features presentations by leaders in the field:

Crystal Mackall, MDStanford University

Yang-Xin Fu, MD, PhDUT Southwestern

Mikala Egeblad, PhDCold Spring Harbor Laboratory

Linda Bradley, PhDSanford Burnham Prebys Medical Discovery Institute

Jose Conejo-Garcia, MD, PhDWistar Institute

Jonathan Powell, MDJohns Hopkins School of Medicine

Shannon Turley, PhDGenentech

Karen Willard-Gallo, PhDInstitut Jules Bordet – Belgium

Sandip Patel, MDUC San Diego

Adam Godzik, PhDSanford Burnham Prebys Medical Discovery Institute

The symposium will be held from 9-4:30 in Fishman Auditorium (overflow seating in the Building 12 auditorium), with a reception to follow. If you plan to attend, please register here.