# Sanford Burnham Prebys

> Sanford Burnham Prebys is dedicated to pushing biomedical discoveries faster and further toward clinical treatment and therapies that improve human lives\.

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## Pages
- [Partnership](https://sbpdiscovery.org/research/partnership/): A relationship with Sanford Burnham Prebys provides access to deep biological knowledge and advanced translational technologies that result in fundamental and pioneering biological insights, pharma\-grade drug discoveries, nimble, collaborative and trusted relationships, fair intellectual property strategies and first\-in\-class projects\.
- [Philanthropy Contact](https://sbpdiscovery.org/philanthropy/contact/)
- [2026 Gala Underwriting Opportunities](https://sbpdiscovery.org/gala/underwriting-opportunities/)
- [2026 Gala Benefactor Opportunities](https://sbpdiscovery.org/gala/benefactor-opportunities/)
- [NCI\-Designated Cancer Center](https://sbpdiscovery.org/research/centers/nci-designated-cancer-center/): One of only eight National Cancer Institute\-designated Basic Laboratory Cancer Centers in the U\.S\., we are a hub for scientific leadership and basic cancer research\.           An active Community Advisory Board further supports our mission, educating the public and advancing patient advocacy\.

## Posts
- [Science in Pictures](https://sbpdiscovery.org/science-in-pictures-jul-13-26/): A weekly image series featuring selected pictures in science • Kidney microvasculature
- [Science in Pictures](https://sbpdiscovery.org/science-in-pictures-7-6-26/): A weekly image series featuring selected pictures in science • Mouse small intestine
- [LEAP scholars share scientific and professional development achievements](https://sbpdiscovery.org/leap-scholars-share-scientific-and-professional-development-achievements/): Postbaccalaureate training program participants deliver capstone presentations, thank mentors and colleagues\.
- [Sanford Burnham Prebys Science Network hosts Community Outreach Symposium showcasing early\-career research](https://sbpdiscovery.org/sanford-burnham-prebys-science-network-hosts-community-outreach-symposium-showcasing-early-career-research/): Graduate students and postdoctoral researchers from across Sanford Burnham Prebys took center stage at the 2026 Community Outreach Symposium, sharing their research with colleagues and mentors from across the Institute, as well as members of the broader community\.
- [Q \& A with Postdoctoral Researcher Kokila Shankar, from the Sheffler Lab](https://sbpdiscovery.org/q-a-with-postdoctoral-researcher-kokila-shankar-from-the-sheffler-lab/): Meet one of our early\-career scientists: postdoctoral researcher Kokila Shankar, from the lab of Douglas Sheffler\. Shankar studies the brain stress signaling system to develop potential treatments for drug addiction\.

## Scientists
- [Kevin Tharp, PhD](https://sbpdiscovery.org/scientists/kevin-tharp-phd/)
- [Xiao Tian, PhD](https://sbpdiscovery.org/scientists/xiao-tian-phd/)
- [Thomas "TC" Chung, PhD](https://sbpdiscovery.org/scientists/thomas-tc-chung-phd/)
- [Sanju Sinha, PhD](https://sbpdiscovery.org/scientists/sanju-sinha-phd/)
- [Shengjie Feng, PhD](https://sbpdiscovery.org/scientists/shengjie-feng-phd/)

## Labs
- [Karin Lab](https://sbpdiscovery.org/labs/karin-lab/): In the Tharp lab, we aim to understand how cells regulate and utilize metabolic programs to adapt to different microenvironments\. Our main goal is to develop therapeutics that prevent cancer cells from metastasizing \- by interfering with their ability to tune their metabolism to survive in secondary sites\.
- [Tharp Lab files](https://sbpdiscovery.org/labs/tharp-lab-files/): In the Tharp lab, we aim to understand how cells regulate and utilize metabolic programs to adapt to different microenvironments\. Our main goal is to develop therapeutics that prevent cancer cells from metastasizing \- by interfering with their ability to tune their metabolism to survive in secondary sites\.
- [Tharp Lab](https://sbpdiscovery.org/labs/tharp-lab/): In the Tharp lab, we aim to understand how cells regulate and utilize metabolic programs to adapt to different microenvironments\. Our main goal is to develop therapeutics that prevent cancer cells from metastasizing \- by interfering with their ability to tune their metabolism to survive in secondary sites\.
- [Marth Lab](https://sbpdiscovery.org/labs/marth-lab/)
- [Bradley Lab](https://sbpdiscovery.org/labs/bradley-lab/): The Bradley Lab is focused on understanding the regulation of T lymphocytes in virus infections where the immune response results in viral clearance and the development of immunologic memory, and in chronic virus infections where the ongoing immune response leads to viral persistence and immune dysregulation\.

## Events
- [Biomedical Research Symposium Alumni Reception »](https://sbpdiscovery.org/events/biomedical-research-symposium-alumni-reception/): As part of our 50th Anniversary celebration, we're hosting an Alumni Reception where you can reconnect with fellow alumni and meet our current graduate students and postdocs\.
- [Inside the Science: Big Ideas from Rare Diseases »](https://sbpdiscovery.org/events/inside-the-science-big-ideas-from-rare-diseases/): Our Discovery Series program offers a behind\-the\-scenes look at research into rare diseases being conducted at Sanford Burnham Prebys Medical Discovery Institute\. The presentation will explore how studying rare diseases helps inform and advance treatments for more common conditions\.
- [37th Annual Usha Mahajani Symposium on Molecular Medicine »](https://sbpdiscovery.org/events/37th-annual-usha-mahajani-symposium-on-molecular-medicine/): Targeting Metabolic Vulnerabilities in Cancer: From Mitochondria to Immunity\. Presented by The Usha Mahajani Committee, Moores Cancer Center at UC San Diego Health, Salk Institute for Biological Studies and Sanford Burnham Prebys\.
- [Cellular recycling in aging and disease – the importance of taking out the trash »](https://sbpdiscovery.org/events/cellular-recycling-in-aging-and-disease-the-importance-of-taking-out-the-trash-2/): Distinguished Cardiovascular and Muscular Diseases Seminar Series: Malene Hansen, PhD, The Buck Institute
- [Community Outreach Symposium »](https://sbpdiscovery.org/events/sbp-sn-outreach-symposium/): The Community Outreach Symposium at Sanford Burnham Prebys is a free community event that gives postdocs and graduate students a platform to sharpen their science communication skills\.

## Leadership
- [Janelle Nelson](https://sbpdiscovery.org/leadership/janelle-nelson/)
- [Liz Hincks](https://sbpdiscovery.org/leadership/liz-hincks/)
- [Reuben Shaw, PhD](https://sbpdiscovery.org/leadership/reuben-shaw-phd/)
- [Dan Theodorescu, MD, PhD](https://sbpdiscovery.org/leadership/dan-theodorescu-md-phd/)
- [Elaine Mardis, PhD](https://sbpdiscovery.org/leadership/elaine-mardis-phd/)

## Trustees
- [Stuart A\. Tanz](https://sbpdiscovery.org/trustees/stuart-a-tanz/)
- [David L\. Szekeres](https://sbpdiscovery.org/trustees/david-l-szekeres/)
- [Lonna J\. Williams Stolper](https://sbpdiscovery.org/trustees/lonna-j-williams-stolper/)
- [Ted Roth](https://sbpdiscovery.org/trustees/ted-roth/)
- [William A\. Roper](https://sbpdiscovery.org/trustees/william-a-roper/)

## Featured Articles
- [RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer’s disease brain](https://sbpdiscovery.org/paper-of-the-week/rna-isoform-diversity-splicing-variants-and-switching-in-single-cells-of-the-alzheimers-disease-brain/)
- [Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non\-Small Cell Lung Cancer](https://sbpdiscovery.org/paper-of-the-week/synthesis-and-characterization-of-ulk1-2-kinase-inhibitors-that-inhibit-autophagy-and-upregulate-expression-of-major-histocompatibility-complex-i-for-the-treatment-of-non-small-cell-lung-cancer/)
- [Tissue morphology predicts telomere shortening in human tissues](https://sbpdiscovery.org/paper-of-the-week/tissue-morphology-predicts-telomere-shortening-in-human-tissues/)
- [Smac mimetic combined with eCD4\-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques](https://sbpdiscovery.org/paper-of-the-week/smac-mimetic-combined-with-ecd4-ig-reverses-latency-without-reducing-shiv-reservoirs-in-rhesus-macaques/)
- [SAKURA: a knowledge\-guided approach to recovering important, rare signals from single\-cell data](https://sbpdiscovery.org/paper-of-the-week/sakura-a-knowledge-guided-approach-to-recovering-important-rare-signals-from-single-cell-data/)

## Press Releases
- [Protective protein reduces tau tangle toxicity linked to dementia](https://sbpdiscovery.org/press/protective-protein-reduces-tau-tangle-toxicity-linked-to-dementia/): Bolstering SORLA protein has potential as a therapeutic strategy for Alzheimer’s disease and other tauopathies\.
- [Pioneering computer biologist Jill Mesirov joins Sanford Burnham Prebys](https://sbpdiscovery.org/press/pioneering-computer-biologist-jill-mesirov-joins-sanford-burnham-prebys/): Jill P\. Mesirov, PhD, a pioneering mathematician and computational biologist, has joined Sanford Burnham Prebys as a Distinguished Professor and Senior Vice President for Computational Science\.
- [Why are people with metabolic liver disease also at higher risk of heart disease?](https://sbpdiscovery.org/press/why-are-people-with-metabolic-liver-disease-also-at-higher-risk-of-heart-disease/): A team led by Debanjan Dhar, PhD, developed a translational model that begins to explain why people with metabolic liver disease are at higher risk of heart disease, offering new insights into cardiometabolic disease\.
- [Parsing the pathology of prostate cancer](https://sbpdiscovery.org/press/parsing-the-pathology-of-prostate-cancer/): Researchers identify epigenetic mechanism that explains why some tumors grow slowly and remain localized but others become aggressive and metastasize\.
- [Sanford Burnham Prebys joins consortium to rewrite the realities of drug discovery](https://sbpdiscovery.org/press/sanford-burnham-prebys-joins-consortium-to-rewrite-the-realities-of-drug-discovery/): Researchers at Sanford Burnham Prebys Medical Discovery Institute will be part of a new, ambitious project to transform the drug discovery process by developing computational models to predict human toxicity, potentially cutting years off development timelines and reducing costs\.

## Magazines
- [Winter 2016](https://sbpdiscovery.org/magazine/winter-2016/)
- [Summer 2016](https://sbpdiscovery.org/magazine/summer-2016/)
- [Summer 2017](https://sbpdiscovery.org/magazine/summer-2017/)
- [Summer 2018](https://sbpdiscovery.org/magazine/summer-2018/)
- [Summer 2011](https://sbpdiscovery.org/magazine/summer-2011/)

## Science 101 Articles
- [Science 101: Brain cancer](https://sbpdiscovery.org/science-101/science-101-brain-cancer/)
- [Science 101: Aging](https://sbpdiscovery.org/science-101/science-101-aging/)
- [Science 101: Breast cancer](https://sbpdiscovery.org/science-101/science-101-breast-cancer/)
- [Science 101: Cell signaling](https://sbpdiscovery.org/science-101/science-101-cell-signaling/)
- [Science 101: Addiction](https://sbpdiscovery.org/science-101/science-101-addiction/)

## Categories
- [Uncategorized](https://sbpdiscovery.org/category/uncategorized/)
- [Research News](https://sbpdiscovery.org/category/researchnews/)
- [What's Happening](https://sbpdiscovery.org/category/whatshappening/)
- [People](https://sbpdiscovery.org/category/people/)
- [Workforce Engagement and Belonging](https://sbpdiscovery.org/category/workforce-engagement-belonging/)

## Tags
- [Cancer Center](https://sbpdiscovery.org/tag/cancercenter/)
- [NIH funding](https://sbpdiscovery.org/tag/nihfunding/)
- [cancer](https://sbpdiscovery.org/tag/cancer/)
- [grants](https://sbpdiscovery.org/tag/grants/)
- [Science in Pictures](https://sbpdiscovery.org/tag/scienceinpictures/)

## Faculty Types
- [Faculty](https://sbpdiscovery.org/faculty-type/faculty/)
- [Staff](https://sbpdiscovery.org/faculty-type/staff/)
- [Emeritus Faculty](https://sbpdiscovery.org/faculty-type/emeritus-faculty/)
- [Research Faculty](https://sbpdiscovery.org/faculty-type/research-faculty/)
- [Adjunct Faculty](https://sbpdiscovery.org/faculty-type/adjunct-faculty/)

##  Positions
- [Member](https://sbpdiscovery.org/scientist-position/member/)
- [Professor](https://sbpdiscovery.org/scientist-position/professor/)
- [Assistant Professor](https://sbpdiscovery.org/scientist-position/assistant-professor/)
- [Director](https://sbpdiscovery.org/scientist-position/director/)
- [Associate Professor](https://sbpdiscovery.org/scientist-position/associate-professor/)

## Related Diseases
- [Cancer](https://sbpdiscovery.org/related-diseases/cancer/)
- [Breast Cancer](https://sbpdiscovery.org/related-diseases/breast-cancer/)
- [Alzheimer's Disease](https://sbpdiscovery.org/related-diseases/alzheimers-disease/)
- [Aging\-Related Diseases](https://sbpdiscovery.org/related-diseases/aging-related-diseases/)
- [Neurodegenerative and Neuromuscular Diseases](https://sbpdiscovery.org/related-diseases/neurodegenerative-and-neuromuscular-diseases/)

## Phenomena or Processes
- [Cell Signaling](https://sbpdiscovery.org/phenomena-processes/cell-signaling/)
- [Cell Biology](https://sbpdiscovery.org/phenomena-processes/cell-biology/)
- [Inflammation](https://sbpdiscovery.org/phenomena-processes/inflammation/)
- [Aging](https://sbpdiscovery.org/phenomena-processes/aging/)
- [Cancer Biology](https://sbpdiscovery.org/phenomena-processes/cancer-biology/)

## Anatomical Systems and Sites
- [Immune System and Inflammation](https://sbpdiscovery.org/anatomical-system-site/immune-system-and-inflammation/)
- [Brain](https://sbpdiscovery.org/anatomical-system-site/brain/)
- [General Cell Biology](https://sbpdiscovery.org/anatomical-system-site/general-cell-biology/)
- [Nervous System](https://sbpdiscovery.org/anatomical-system-site/nervous-system/)
- [Vasculature](https://sbpdiscovery.org/anatomical-system-site/vasculature/)

## Research Models
- [Mouse](https://sbpdiscovery.org/research-models/mouse/)
- [Human Cell Lines](https://sbpdiscovery.org/research-models/human-cell-lines/)
- [Mouse Cell Lines](https://sbpdiscovery.org/research-models/mouse-cell-lines/)
- [Primary Human Cells](https://sbpdiscovery.org/research-models/primary-human-cells/)
- [Primary Cells](https://sbpdiscovery.org/research-models/primary-cells/)

## Techniques and Technologies
- [Cellular and Molecular Imaging](https://sbpdiscovery.org/techniques-technologies/cellular-and-molecular-imaging/)
- [Bioinformatics](https://sbpdiscovery.org/techniques-technologies/bioinformatics/)
- [Drug Discovery](https://sbpdiscovery.org/techniques-technologies/drug-discovery/)
- [Fluorescence Microscopy](https://sbpdiscovery.org/techniques-technologies/fluorescence-microscopy/)
- [Gene Expression](https://sbpdiscovery.org/techniques-technologies/gene-expression/)

## Leadership Types
- [Board of Directors](https://sbpdiscovery.org/leadership-type/board-of-directors/)
- [Administrative](https://sbpdiscovery.org/leadership-type/administrative/)
- [Scientific](https://sbpdiscovery.org/leadership-type/scientific/)
- [Management](https://sbpdiscovery.org/leadership-type/management/)
- [Scientific Advisory Board](https://sbpdiscovery.org/leadership-type/sab/)

## Page Types
- [Shared Resource](https://sbpdiscovery.org/page-type/shared-resource/)
- [Tribute](https://sbpdiscovery.org/page-type/tribute/)
- [Center](https://sbpdiscovery.org/page-type/center/)
- [Theme](https://sbpdiscovery.org/page-type/theme/)
- [Program](https://sbpdiscovery.org/page-type/program/)

## Event Types
- [Seminar](https://sbpdiscovery.org/event-type/seminar/)
- [Symposium](https://sbpdiscovery.org/event-type/symposium/)
- [Community Forum](https://sbpdiscovery.org/event-type/community-forum/)
- [Other](https://sbpdiscovery.org/event-type/other/)

## Event Categories
- [Cancer Center Seminar Series](https://sbpdiscovery.org/event-category/cancer-center-seminar-series/)
- [DEIB](https://sbpdiscovery.org/event-category/deib/)

## Optional
- [Sitemap index](https://sbpdiscovery.org/sitemap_index.xml)