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Neuroscience Initiative

An institute-wide effort to bring together SBP researchers to apply multidisciplinary approaches to problems in fundamental and translational research in Neuroscience.

Overview

The Neuroscience Initiative at SBP (SBPNI) is an institute-wide effort to bring together SBP researchers to apply multidisciplinary approaches to problems in fundamental and translational research in Neuroscience. The goals of this initiative are to understand cellular and molecular processes required for brain homeostasis and to identify deficiencies in neurological and neurodegenerative disease. The initiative aims to strengthen collaborations between SBP scientists, expand the range of scientific expertise and research capabilities and foster research alliances with industry partners working in neuroscience and drug discovery research with the ultimate goal of translating novel ideas and discoveries into therapies that improve the life of patients suffering from brain diseases.

What is the focus of our program — what questions are we asking?

The SBP Neuroscience Initiative (SBPNI) integrates institution-wide research on neuroscience and is focused on deepening the understanding of the cellular and molecular basis of brain homeostasis and disease-causing processes in brain. Our research aims at identifying the principles of neuronal interactions with signals from the cellular microenvironment and uncovering disease-relevant targets that can be harnessed to drive drug discovery efforts in neurological and age-related neurodegenerative diseases. In an effort to achieve these goals, we have established interdisciplinary partnerships devoted to the study of basic biological processes and signaling pathways targeted by neurodegeneration in Alzheimer’s and Parkinson’s disease, tauopathies, Down syndrome, neurometabolic disease (including obesity & diabetes), motor neuron disease and traumatic brain injury.


How will our research help patients?

Combined understanding of healthy brain functions and disruptions in neurological disease places Neuroscience laboratories at SBP at the forefront of knowledge to identify disease-relevant targets and design screens for promising new drugs that can slow, halt or prevent the progression of neurological disorders. Our goal is to kick-start the drug discovery process as early as possible by removing translational delays in the transition of drug development from bench to bedside.  Working with SBP's Conrad Prebys Center for Chemical Genomics, we are uniquely positioned for the state-of-art drug discovery process with world-class experts in pharmaceutical and biotech drug discovery.


Research Highlights

Publications

Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G
J Exp Med 2017 Mar 6;214(3):597-607
Zheng H, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G
J Neurosci 2017 Feb 15;37(7):1772-1784
Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H
J Neurosci 2016 Dec 14;36(50):12586-12597