Dennis Otero, Ph.D.

Dennis Otero's Research Focus

Inflammatory/Autoimmune Disease, Inflammatory Bowel Disease, Immune Disorders, Multiple Sclerosis, Type 1 Diabetes
Immune System and Inflammation
Cell Biology

Dennis works in the Bradley lab where he investigates autoimmune disease and immune checkpoint modulators that can be used to block autoimmune disease or promote an immune response to virus or tumor cells.

Dennis Otero's Bio

Previously, he was a postdoc and project scientist at UCSD, where he also received his Ph.D.


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Publications

IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.

Otero DC, Fares-Frederickson NJ, Xiao M, Baker DP, David M

J Immunol 2015 Jun 1 ;194(11):5120-8

T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.

Moro H, Otero DC, Tanabe Y, David M

PLoS One 2011 ;6(9):e24972

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Siah2 control of T-regulatory cells limits anti-tumor immunity.

Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA

Nat Commun 2020 Jan 7 ;11(1):99

Striking a Balance-Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation.

Hope JL, Stairiker CJ, Bae EA, Otero DC, Bradley LM

Front Immunol 2019 ;10:1595

PSGL-1: A New Player in the Immune Checkpoint Landscape.

Tinoco R, Otero DC, Takahashi AA, Bradley LM

Trends Immunol 2017 May ;38(5):323-335

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM

Immunity 2016 Jun 21 ;44(6):1470

PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.

Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM

Immunity 2016 May 17 ;44(5):1190-203

B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.

Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A

Blood 2016 Mar 10 ;127(10):1276-86

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