Paper of the Week Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer February 28, 2019 Loss of PKCλ/ι promotes basal and NEPC features in vivo PKCλ/ι represses mTORC1 activation through LAMTOR2 phosphorylation... Read more
Paper of the Week Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma January 28, 2019 A subset of medulloblastomas are driven by enhancer hijacking of GFI1 family proteins GFI1 acts by recruiting epigenetic... Read more
Paper of the Week Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy January 21, 2019 Dystrophic disease progression accelerates rhabdomyosarcoma (RMS) formation MuSCs carry a gene signature characteristic of... Read more
Paper of the Week Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila January 13, 2019 High-fat diet (HFD) causes lipotoxic cardiomyopathy (LCM) that persists for two progeny generations in Drosophila.... Read more
Paper of the Week Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance December 11, 2018 Atypical protein kinase C (aPKC) expression is reduced in human serrated tumors Deletion of both aPKCs in intestinal... Read more
