Paper of the Week Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila January 14, 2019 High-fat diet (HFD) causes lipotoxic cardiomyopathy (LCM) that persists for two progeny generations in Drosophila.... Read more
Paper of the Week Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance December 11, 2018 Atypical protein kinase C (aPKC) expression is reduced in human serrated tumors Deletion of both aPKCs in intestinal... Read more
Paper of the Week Somatic APP gene recombination in Alzheimer’s disease and normal neurons November 21, 2018 First description of somatic gene recombination in the brain. Involves RNA intermediates that are reverse transcribed and... Read more
Paper of the Week A Recurrent De Novo Heterozygous COG4 Substitution Leads to Saul-Wilson Syndrome, Disrupted Vesicular Trafficking, and Altered Proteoglycan Glycosylation October 22, 2018 Single heterozygous COG4 mutation causes Saul-Wilson Syndrome (SWS) SWS alters Golgi morphology, volume and trafficking SWS... Read more
Paper of the Week Accelerated aging and clearance of host anti-inflammatory enzymes by a subset of pathogens fuels sepsis October 10, 2018 The pathophysiology of sepsis can be stratified by pathogens and host responses Host neuraminidases induced by LPS activation... Read more
