Paper of the Week Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation September 10, 2019 MYOD re-wires chromatin interactions during nuclear reprogramming toward myogenesis MYOD reconfigures structural genomic... Read more
Paper of the Week EGFR/Pak Signaling Selectively Regulates Glutamine-Deprivation-Induced Macropinocytosis June 27, 2019 Enhanced macropinocytosis coincides with amino acid deficiency in PDAC tumors Glutamine depletion specifically induces... Read more
Paper of the Week Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment May 23, 2019 Reduction of the astrocytic glutamate transporter EAAT2 contributes to excitotoxic motor neuronal degeneration in ALS.... Read more
Paper of the Week An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors May 6, 2019 Mutated KRAS, occurring in approximately 25% of human cancers, has no effective treatment. Inhibition of the KRAS regulator... Read more
Paper of the Week Engineering Nanomolar Peptide LigandsThat Differentially Modulate EphA2 Receptor Signaling April 29, 2019 Both activation and inhibition of EphA2 have therapeutic value Structure-guided engineering yielded potent and selective... Read more
