Victoria Blaho, Ph.D.

Victoria Blaho's Research Focus

Immune Disorders, Leukemia/Lymphoma, Inflammatory/Autoimmune Disease, Multiple Sclerosis
Apoptosis and Cell Death, Cell Signaling, Hematopoiesis, Innate Immunity, Adaptive Immunity, G-Protein Coupled Receptors, Inflammation
Hematopoietic System, Immune System and Inflammation, Vasculature
Human Adult/Somatic Stem Cells, Mouse Somatic Stem Cells, Mouse, Primary Cells

The lipid sphingosine 1 phosphate (S1P) is found in high levels in the blood and lymph and is primarily carried by the protein ApoM, found on HDL. S1P can affect the cardiovascular, nervous, and immune systems via interaction with cell surface-expressed receptors, S1P1-5. My work is determining how changing S1P carrier or receptor expression and signaling can affect cells of the immune system, particularly in the bone marrow, and how this alters their ability to respond to stress or infection.

Victoria Blaho's Bio

Dr. Blaho began her research career focused on how bioactive lipids contribute to the innate immune response against bacterial infection, characterizing roles for eicosanoids in the generation and resolution of Lyme arthritis pathology. The wild diversity of lipid species led Dr. Blaho to Weill Cornell Medical College in New York City to pursue postdoctoral training in the field of sphingolipids, particularly sphingosine 1-phosphate (S1P), and its receptors. Advancing to Instructor at Weill Cornell and later, Research Assistant Professor at SBP, Dr. Blaho continued her research in lipid chaperones and receptor signaling, with an emphasis on cell-type differential effects on hematopoiesis and immunity in response to cell stressors. In August of 2019, Dr. Blaho joined the faculty at SBP Medical Discovery Institute as an Assistant Professor in the Immunity and Pathogenesis program.


Education

  • Instructor - Weill Cornell Medicine, Pathology and Laboratory Medicine and Neuroscience - 2014-2016
  • Post-doctoral training - Weill Cornell Medicine, Pathology and Laboratory Medicine - 2009-2014
  • Post-doctoral training - University of Missouri, Columbia, Veterinary Pathobiology - 2007-2009
  • Ph.D.  - University of Missouri, Columbia, Molecular Microbiology and Immunology - 2007 B.S.
     

Funding Awards and Collaborative Grants

  • National Heart, Lung, and Blood Institute R01

  • American Heart Association Scientist Development Grant

  • Leon Levy Neuroscience Foundation Grant  (2014-15)

  • Foundation LeDucq SphingoNet Young Investigator Grant (2015)

  • National Cancer Institute Individual Ruth L. Kirschstein Post-doctoral Fellowship (2009-12)

 

Honors and Recognitions

  • 2017    British Journal of Pharmacology Lecture: FASEB Summer Research Conference on Lysophospholipids and Related Mediators – from bench to clinic.

  • 2014    Leon Levy Foundation Neuroscience Fellow

  • 2010   Keystone Scholarship, Bioactive Lipids: Biochemistry and Diseases

  • 2008   Keystone Scholarship, Eicosanoids and Other Mediators of Chronic Inflammation

  • 2007    Young Investigator Award in Inflammation, Eicosanoid Research Foundation

  • 2004    National Academy of Sciences Christine Mirzayan Policy Fellow, Institute of Medicine Board on Health Sciences Policy
     

pipetting

Publications

Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T
Nature 2015 Jul 16;523(7560):342-6
Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T
Sci Signal 2015 Aug 11;8(389):ra79
Blaho VA, Hla T
J Lipid Res 2014 Aug;55(8):1596-608
Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X
Front Immunol 2019;10:404
Chun J, Kihara Y, Jonnalagadda D, Blaho VA
Annu Rev Pharmacol Toxicol 2019 Jan 6;59:149-170
Blaho VA, Chun J
Trends Pharmacol Sci 2018 Nov;39(11):953-966