Elena Pasquale’s new review in Nature Reviews Cancer surveys the large body of data regarding Eph signaling in tumors and highlights potential strategies for therapeutic targeting. “Overall, while significant progress has been made in deciphering the Eph system in cancer, there is much more to learn.”
Over the last decade, the publications of Randal J. Kaufman are among the top 1% in the world by number of citations. He has been a major contributor to our understanding of how protein folding—and misfolding—lead to cell malfunctions and death.
Addiction is perhaps the most and least visible of public health crises in the United States. Tens of millions of Americans are addicted to illicit drugs, alcohol, tobacco and other substances including opioids, with both immediate and long-term harm to not just themselves, but also family, friends and society.
Unique DNA loops found outside regular chromosomes are linked to poor clinical outcomes in aggressive childhood brain cancers. The new study, led by Lukas Chavez and published in Nature Genetics, may transform the treatment of these rare cancers.
The Sanford Burnham Prebys medical research institute in La Jolla held a gala called “A Future Filled With Discoveries and Cures” on Oct. 21 at the Estancia La Jolla Hotel & Spa to extoll its recruitment of “the very best scientists from the best labs at the best institutions in the world.”
Sanford Burnham Prebys’ latest gala celebrated an old, dear friend, a brand-new vision and a crowd in fab form. More than 280 friends, faculty and supporters of the Institute gathered to celebrate the event’s theme: “A Future Filled with Discoveries and Cures.”
The laboratory, with its precise protocols and sterile tools, seems far removed from the often discordant chaos of U.S. society. But science does not happen in a socio-political vacuum, says Eric Lau, Ph.D., a former student and postdoc at Sanford Burnham Prebys, and research institutions shouldn’t pretend otherwise.
Researchers at Stanford University School of Medicine and Sanford Burnham Prebys have discovered that targeting an enzyme associated with aging after nerve injury in a mouse model with a small molecule inhibitor, promoted regeneration of motor nerve and formation of neuromuscular synapses that resulted in accelerated recovery of strength.
A study led by Institute scientists suggests an entirely new approach to treat pancreatic cancer. The research shows that feeding tumors a copycat of an important nutrient starves them of the fuel they need to survive and grow.
NCI-Designated Cancer Center
Earning the NCI designation in 1981 — just five years after its modest start in downtown La Jolla — our Cancer Center truly is "the miracle on Torrey Pines Mesa."
This one day event will showcase expert scientists who are making impactful contributions to the field of pancreatic cancer research, including tumorigenesis, tumor progression, and the discovery of novel therapeutic paradigms, such as immunomodulation and metabolic targeting