Sanford Burnham Prebys is uncovering the origins of disease
to maximize their impact on human health
needed to solve medicine's most challenging problems
meaningful clinical benefit and growing further discovery
The Latest News
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In the News
Opinion: Mathew Perry was open about addiction. Like him, we can’t stop trying to overcome it.
David Brenner’s essay “Opinion: Mathew Perry was open about addiction. Like him, we can’t stop trying to overcome it,” is now available through the San Diego Union-Tribune’s Community Voices Project. The monthly column is a forum for respectful discourse about news of the day and matters of the community that brings thought leaders together in a public dialogue, which can be a model for others. -
Elena Pasquale’s new review in Nature Reviews Cancer surveys the large body of data regarding Eph signaling in tumors and highlights potential strategies for therapeutic targeting. “Overall, while significant progress has been made in deciphering the Eph system in cancer, there is much more to learn.”
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Creating an inclusive environment in STEM is crucial for ensuring a broad range of perspectives and ideas, ultimately contributing to the advancement of scientific research and innovation.
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Genetic Disorders and Aging
Randal J. Kaufman among the world’s most influential scientists
Over the last decade, the publications of Randal J. Kaufman are among the top 1% in the world by number of citations. He has been a major contributor to our understanding of how protein folding—and misfolding—lead to cell malfunctions and death. -
Addiction is perhaps the most and least visible of public health crises in the United States. Tens of millions of Americans are addicted to illicit drugs, alcohol, tobacco and other substances including opioids, with both immediate and long-term harm to not just themselves, but also family, friends and society.
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Unique DNA loops found outside regular chromosomes are linked to poor clinical outcomes in aggressive childhood brain cancers. The new study, led by Lukas Chavez and published in Nature Genetics, may transform the treatment of these rare cancers.
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Hudson Freeze joined an international panel of genetics experts on CAD deficiency: Beyond the genetics—a podcast offered by the Journal of Inherited Metabolic Disease.
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The Sanford Burnham Prebys medical research institute in La Jolla held a gala called “A Future Filled With Discoveries and Cures” on Oct. 21 at the Estancia La Jolla Hotel & Spa to extoll its recruitment of “the very best scientists from the best labs at the best institutions in the world.”
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Community
With a little help from my friends
Sanford Burnham Prebys’ latest gala celebrated an old, dear friend, a brand-new vision and a crowd in fab form. More than 280 friends, faculty and supporters of the Institute gathered to celebrate the event’s theme: “A Future Filled with Discoveries and Cures.” -
The laboratory, with its precise protocols and sterile tools, seems far removed from the often discordant chaos of U.S. society. But science does not happen in a socio-political vacuum, says Eric Lau, Ph.D., a former student and postdoc at Sanford Burnham Prebys, and research institutions shouldn’t pretend otherwise.
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Researchers at Stanford University School of Medicine and Sanford Burnham Prebys have discovered that targeting an enzyme associated with aging after nerve injury in a mouse model with a small molecule inhibitor, promoted regeneration of motor nerve and formation of neuromuscular synapses that resulted in accelerated recovery of strength.
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Genetic Disorders and Aging
Inhibiting an enzyme associated with aging could help damaged nerves regrow and restore strength
New research has demonstrated a way to accelerate recovery from peripheral nerve injury by targeting an enzyme that was thought to be responsible for muscle wasting with aging.
Living History
NCI-Designated Cancer Center
Earning the NCI designation in 1981 — just five years after its modest start in downtown La Jolla — our Cancer Center truly is "the miracle on Torrey Pines Mesa."

Years in the Making
Yasuyuki Kihara wins a dream award
Research Assistant Professor Yasuyuki Kihara, Ph.D., has won an Eicosanoid Research Foundation (ERF) Young Investigator Award, an award for researchers working in lipid biology.

Living History
Along the road to discovery
It was in 1979 when Eva Engvall asked Erkki Ruoslahti a question that would change their lives forever: "Wouldn't it be great to work in San Diego?"

Next Generation
Graduate student Katja Birker's research doesn't miss a beat
"There is no magic wand to cure congenital heart conditions–we have to do the research."

Calendar
Seminar
Stanford University School of Medicine
Symposium
Symposium
Our Partners in Discovery
We can't do it alone
Our annual Rare Disease Day symposium strengthens the global network of families, physicians and researchers to better understand and fight rare diseases in children.

Our Partners in Discovery
Getting to the finish line faster
Thanks to the philanthropic vision of Stuart and Karen Tanz, a unique collaboration seeks new treatments for diseases such as Alzheimer’s, dementia and Parkinson’s.

Our Partners in Discovery
New hope for autoimmune disease
Our partnership with Lilly—centered around a high degree of interaction—has already produced an immune therapy now in clinical trial.

Our Partners in Discovery
A master class in collaboration
Meet T. Denny Sanford, Conrad Prebys and Malin Burnham: three people who know we're stronger when we work together.
