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Institute News

Sanford-Burnham researchers identify a new target for treating drug-resistant melanoma

Authorsgammon
Date

May 28, 2015

A new collaborative study led by researchers at Sanford-Burnham, published today in Cell Reports, provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs called BRAF inhibitors. The findings suggest that targeting newly discovered pathways could be an effective approach to improving the clinical outcome of patients with BRAF inhibitor-resistant melanoma tumors. Continue reading “Sanford-Burnham researchers identify a new target for treating drug-resistant melanoma”

Institute News

Highlights from the Graduate School of Biomedical Sciences annual retreat

Authorsgammon
Date

May 27, 2015

On May 13-18, Sanford-Burnham’s Graduate School of Biomedical Sciences held its sixth annual retreat in San Marcos, Calif.

This year’s theme, “Effectively Communicating Scientific Research to a Broad Audience,” gave the students an opportunity to share their research and practice explaining their work in simple terms—simple enough for non-scientists.

Organized by Francesca Boscolo Sesillo, Mirco Guigli, and Gianluigi Lichinchi, all graduate students at the Institute, the presenters were encouraged to address questions such as:

  • Why the research is important
  • How will it advance our understanding of the subject matter
  • Will the research impact human health

As a very grateful invited guest, I was dazzled by the presentations. Many of the students included analogies and graphics that made some very complex information—structured illumination resolution, haploinsuffient photoreceptors, SWI/SNF BRAHMA chromatin remodeling, just to name a few—clear enough for this “arm-chair” scientist to be dangerous.

 

For many reasons, effectively communicating science to non-scientists and scientists within other disciplines is critical. Like it or not, when you explain science you are selling. You may be selling your ideas to seek funding and grants, convincing others of your findings, or recruiting people to work on your project.

The students took it seriously, not only because many of their mentors and advisors were in the audience, but also because they were scored on a scale of 1-5 for quality, content, and clarity of the presentations. When the score cards were tallied the winner was… (drum roll, please)

Francesca Boscolo Sesillo (Sacco Lab)

Francesca, a third year student, presented her research on the role of p21 during skeletal muscle regeneration. Her findings show that p21, a cell cycle inhibitor, plays a key role in the activation and differentiation of muscle stem cells.  Understanding the mechanisms that lead to muscle regeneration has important implications for future interventions that can improve muscle health in the elderly as well people with degenerative disorders such as muscular dystrophy.

 

Many congratulations to all the fabulous students, and to Guy Salvesen, Ph.D., Dean of the Graduate School, for providing leadership and education opportunities for the students.

And a special thanks to:

  • Fiona Scott, PhD, Associate Director of Biology at Receptos, who shared her professional experience as scientist in clinical research.
  • Thomas Baldwin, PhD, Dean of Natural and Agricultural Sciences at UC Riverside for contributing to the communication training provided to the students.
  • America Vega and Stacy Smith for organizing the retreat.
  • And to Pfizer, Genentech, and Receptos, for underwriting the event.

 

 

 

Institute News

Sanford-Burnham recognized as a trailblazer in water conservation

Authorsgammon
Date

May 11, 2015

If you live in California—especially Southern California—you know that water is scarce. So scarce that the governor is ordering a statewide, across-the-board 25 percent cut in water use. Although the targets for water reduction in commercial, institutional, and industrial settings haven’t been established, the life-science research industry is finding ways to face the water shortage. Perhaps they can take some pointers from Sanford-Burnham—recently recognized as a leader in conservation efforts. Continue reading “Sanford-Burnham recognized as a trailblazer in water conservation”

Institute News

Protein that prevents weight gain

Authorsgammon
Date

May 6, 2015

Let’s face it: Exercise is not for everyone. Even though it has unquestionable health benefits, some people just can’t—or won’t—do it. A busy schedule, previous failed attempts, lack of results, injuries, or just plain boredom are common reasons why people find exercise hard. But when the amount of energy (calories) we take in exceeds the amount going out, our bodies experience an energy imbalance, and we become overweight and are at risk of obesity. And obesity comes with more than a social stigma, it’s associated with a myriad of health problems including heart disease, diabetes, and cancer. Continue reading “Protein that prevents weight gain”

Institute News

Cells on the run: researchers discover a protein required for cell motility

Authorsgammon
Date

April 28, 2015

Your cells move. They need to move for good reasons, such as when white blood cells travel to heal wounds, and for bad reasons, like when cancer cells invade surrounding tissue to metastasize. To move, cells create extensions—like feet—that make contact with a surface and lead the cell to its destination. The abnormal production of these cell extensions is associated with Alzheimer’s disease, epilepsy, and many other neurological disorders. For these reasons, scientists are working to understand the fundamental components of cell movement. What they find may lead to treatments that can promote cell movement when you need it, and prevent it when you don’t. Continue reading “Cells on the run: researchers discover a protein required for cell motility”

Institute News

Protecting pancreatic cells from stress could hold promise for treating diabetes

Authorsgammon
Date

April 21, 2015

Type 2 diabetes is a chronic disease that affects about eight percent of adults worldwide, significantly increasing the risk of heart disease and stroke. This disease interferes with the body’s ability to make or use a hormone called insulin, which is produced by beta cells in the pancreas. These cells eventually fail in many patients with type 2 diabetes, making insulin replacement therapy a necessity for survival. However, this treatment is imprecise, onerous and often promotes weight gain, highlighting the strong need for better treatment options. Continue reading “Protecting pancreatic cells from stress could hold promise for treating diabetes”

Institute News

Cancer metabolism 101

Authorsgammon
Date

April 21, 2015

“Feed me!” Cancer is caused by the uncontrolled proliferation of cells. Their rapid growth comes with a voracious appetite to support their nutritional demands. To satisfy these demands, cancer cells rewire their metabolism. Increasingly, scientists are looking to exploit the metabolic differences between normal and cancer cells for the development of new anti-cancer therapies. Continue reading “Cancer metabolism 101”

Institute News

Sanford-Burnham presents at AACR April 19-22

Authorsgammon
Date

April 21, 2015

 

The American Association of Cancer Research (AACR) Annual Meeting, held April 18-22 in Philadelphia, will attract approximately 18,000 attendees from around the world. They are coming to hear from an outstanding roster of speakers, hundreds of live talks, and more than 6,000 proffered papers from scientists and clinicians around the world. This year’s theme, “Brining Cancer Discoveries to patients,” highlights the need to link laboratory discoveries to treatments for the purpose of finding cancer cures. Continue reading “Sanford-Burnham presents at AACR April 19-22”

Institute News

Discovery of new role of SOX2 protein sheds light on neurogenesis in the adult brain

Authorsgammon
Date

April 21, 2015

 

Newborn neurons generated from neural progenitor cells in a brain region called the hippocampus play an important role in learning and memory in adults. However, the molecular mechanisms that control this neurogenesis process have not been fully understood. Sanford-Burnham researchers recently shed new light on this question by discovering a key role of a protein called SOX2 in neuronal development. As reported online in Proceedings of the National Academy of Sciences, SOX2 promotes the activation of genes involved in differentiation, enabling neural progenitor cells to turn into mature neurons in the brains of adult mice. Continue reading “Discovery of new role of SOX2 protein sheds light on neurogenesis in the adult brain”

Institute News

The science behind the Pedal the Cause cancer research awards

Authorsgammon
Date

March 26, 2015

Pedal the Cause, the nonprofit organization dedicated to raising funds for cancer research, recently announced the funding awards for collaborative translational research projects for scientists at Sanford-Burnham, UC San Diego (Moores Cancer Center), and the Salk Institute. This means that scientists from these organizations will join together and embark on projects centered on what occurs “from bench to bedside” in the development of new drug treatment options for patients. Continue reading “The science behind the Pedal the Cause cancer research awards”