Taking aim at cancer
“Our Cancer Center is committed to performing impactful translational multi-disciplinary research that addresses unmet clinical needs relevant to the diagnosis and treatment of cancer.”
– Ze'ev Ronai, Ph.D., Center Director
Tumor Initiation and Maintenance Program
Understanding the cells that give rise to tumors and the signals allowing them to expand uncontrollably will help us learn how to defeat cancer.
Cell and Molecular Biology of Cancer Program
Insights into the complex system of networks and mechanisms that tumors use to survive and proliferate will lead us to tumor-specific, less toxic therapies.
BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway.
Chen X, Cao X, Tu X, Alitongbieke G, Xia Z, Li X, Chen Z, Yin M, Xu D, Guo S, Li Z, Chen L, Zhang X, Xu D, Gao M, Liu J, Zeng Z, Zhou H, Su Y, Zhang XK
Mol Cancer Ther 2019 May ;18(5):886-899
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection.
McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C
PLoS Pathog 2019 Mar ;15(3):e1007667
Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA
Trends Mol Med 2019 May ;25(5):428-443
Klein BJ, Deshpande A, Cox KL, Xuan F, Zandian M, Barbosa K, Khanal S, Tong Q, Zhang Y, Zhang P, Sinha A, Bohlander SK, Shi X, Wen H, Poirier MG, Deshpande AJ, Kutateladze TG
Nat Commun 2021 Jul 5 ;12(1):4130
iRGD-liposomes enhance tumor delivery and therapeutic efficacy of antisense oligonucleotide drugs against primary prostate cancer and bone metastasis.
Guan J, Guo H, Tang T, Wang Y, Wei Y, Seth P, Li Y, Dehm SM, Ruoslahti E, Pang HB
Adv Funct Mater 2021 Jun 9 ;31(24)
Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, Greengard P
J Exp Med 2021 Aug 2 ;218(8)
IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells.
Magidey-Klein K, Cooper TJ, Kveler K, Normand R, Zhang T, Timaner M, Raviv Z, James BP, Gazit R, Ronai ZA, Shen-Orr S, Shaked Y
J Immunother Cancer 2021 Jun ;9(6)
A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain.
Light TP, Gomez-Soler M, Wang Z, Karl K, Zapata-Mercado E, Gehring MP, Lechtenberg BC, Pogorelov TV, Hristova K, Pasquale EB
J Biol Chem 2021 Jun 15 ;297(1):100876
Rousso-Noori L, Mastandrea I, Talmor S, Waks T, Globerson Levin A, Haugas M, Teesalu T, Alvarez-Vallina L, Eshhar Z, Friedmann-Morvinski D
Nat Commun 2021 Jun 14 ;12(1):3615