Sanford Children's Health Research Center

Sanford Children's Health Research Center

Sanford Children's Health Research Center logoDiseases that predominantly affect children are too often unaddressed by the biopharmaceutical industry and government funding agencies.

"I have the utmost confidence that we can discover solutions to some of the most troubling health issues that affect children."

Denny Sanford, Naming donor and Honorary Trustee


A world leader in providing solutions to childhood diseases

Our mission is to generate translational discoveries about such childhood diseases as diabetes, Duchenne muscular dystrophy, hypophosphatasia (bone disorders), and congenital disorders of glycosylation.


Human Genetics Program

We are discovering the genetic roots of human disorders and translating that knowledge for patient well-being and potential treatments.

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March 1–3, 2024

In 2024, in partnership with CDG CARE and the Sanford Children’s Health Research Center, the Sanford Burnham Prebys Rare Disease Day Symposium will continue to focus on Congenital Disorders of Glycosylation “CDG Models and Therapy”.

Learn more & Register

Latest news


Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.

Plaut JS, Strzelecka-Kiliszek A, Bozycki L, Pikula S, Buchet R, Mebarek S, Chadli M, Bolean M, Simao AMS, Ciancaglini P, Magrini A, Rosato N, Magne D, Girard-Egrot A, Farquharson C, Esener SC, Millan JL, Bottini M

Arch Biochem Biophys 2019 May 30 ;667:14-21

Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury.

Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth M, Schneckmann R, Homann S, Müller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kötter S, Krüger M, Heinen A, Kelm M, Gödecke A, Flögel U, Fischer JW

Circ Res 2019 May 10 ;124(10):1433-1447

Arrest of Fetal Brain Development in ALG11-Congenital Disorder of Glycosylation.

Mulkey SB, Ng BG, Vezina GL, Bulas DI, Wolfe LA, Freeze HH, Ferreira CR

Pediatr Neurol 2019 May ;94:64-69

ALG13-Congenital Disorder of Glycosylation (ALG13-CDG): Updated clinical and molecular review and clinical management guidelines.

Shah R, Eklund EA, Radenkovic S, Sadek M, Shammas I, Verberkmoes S, Ng BG, Freeze HH, Edmondson AC, He M, Kozicz T, Altassan R, Morava E

Mol Genet Metab 2024 Apr 23 ;142(2):108472

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.

Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Schmidt S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, de Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M

Proc Natl Acad Sci U S A 2024 May 7 ;121(19):e2319057121

A complement C4-derived glycopeptide is a biomarker for PMM2-CDG.

Garapati K, Budhraja R, Saraswat M, Kim J, Joshi N, Sachdeva GS, Jain A, Ligezka AN, Radenkovic S, Ramarajan MG, Udainiya S, Raymond K, He M, Lam C, Larson A, Edmondson AC, Sarafoglou K, Larson NB, Freeze HH, Schultz MJ, Kozicz T, Morava E, Pandey A

JCI Insight 2024 Apr 8 ;9(7)

Glycoproteomic profile of human tissue-nonspecific alkaline phosphatase expressed in osteoblasts.

Atanasova D, Mirgorodskaya E, Moparthi L, Koch S, Haarhaus M, Narisawa S, Millán JL, Landberg E, Magnusson P

JBMR Plus 2024 Feb ;8(2):ziae006

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition.

Chang HW, Lee EM, Wang Y, Zhou C, Pruss KM, Henrissat S, Chen RY, Kao C, Hibberd MC, Lynn HM, Webber DM, Crane M, Cheng J, Rodionov DA, Arzamasov AA, Castillo JJ, Couture G, Chen Y, Balcazo NP Jr, Lebrilla CB, Terrapon N, Henrissat B, Ilkayeva O, Muehlbauer MJ, Newgard CB, Mostafa I, Das S, Mahfuz M, Osterman AL, Barratt MJ, Ahmed T, Gordon JI

Nat Microbiol 2024 Apr ;9(4):922-937

Rescuing lung development through embryonic inhibition of histone acetylation.

Stokes G, Li Z, Talaba N, Genthe W, Brix MB, Pham B, Wienhold MD, Sandok G, Hernan R, Wynn J, Tang H, Tabima DM, Rodgers A, Hacker TA, Chesler NC, Zhang P, Murad R, Yuan JX, Shen Y, Chung WK, McCulley DJ

Sci Transl Med 2024 Jan 31 ;16(732):eadc8930

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