How cancer begins
Cells become cancerous after acquiring a series of mutations in their DNA, which occur as a result of exposure to radiation, cigarette smoke, dietary components or a genetic predisposition.
Mutations may intensify or eliminate the messages cells use to grow, stop growing or die. Cells then begin to divide too often and are unable to die, forming tumors. Identifying the mutations, signals and mechanisms that promote and sustain tumors creates new opportunities to target human cancer.
We’ve brought together scientists with expertise in developmental and stem cell biology with investigators who focus on RNA biology and the signaling pathways that regulate cell growth and cell fate. The diversity of our faculty members, along with our shared interests in what drives cancer cell growth, is fostering strong interactions that will lead to breakthrough treatments for brain, breast and prostate cancers, as well as melanoma and leukemia.
– Robert Wechsler-Reya, Ph.D., Program Director
Lee SW, Zhang Y, Jung M, Cruz N, Alas B, Commisso C
Dev Cell 2019 Aug 5 ;50(3):381-392.e5
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Nat Commun 2019 Jan 18 ;10(1):332
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Nat Commun 2019 Apr 2 ;10(1):1492
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Cell Stress 2021 Feb 18 ;5(3):37-39
Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor.
Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK
Mol Ther Oncolytics 2021 Mar 26 ;20:265-276
Miller KN, Dasgupta N, Liu T, Adams PD, Vizioli MG
Elife 2021 Jan 29 ;10
Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma.
Endersby R, Whitehouse J, Pribnow A, Kuchibhotla M, Hii H, Carline B, Gande S, Stripay J, Ancliffe M, Howlett M, Schoep T, George C, Andradas C, Dyer P, Schluck M, Patterson B, Tacheva-Gigorova SK, Cooper MN, Robinson G, Stewart C, Pfister SM, Kool M, Milde T, Gajjar A, Johns T, Wechsler-Reya RJ, Roussel MF, Gottardo NG
Sci Transl Med 2021 Jan 20 ;13(577)
Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C
Cell 2021 Jan 21 ;184(2):352-369.e23
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Int J Oncol 2020 Dec ;57(6):1245-1261