The director of SBP’s Cardiovascular Metabolism Program was recently elected into a pre-eminent honor society for physician-scientists. Peter Crawford, MD, PhD, was one of 74 medical researchers whose nominations to the American Society for Clinical Investigation (ASCI) were accepted in 2016. This distinction is conferred only on investigators who have made significant scientific advances prior to the age of 50. Continue reading “Peter Crawford, MD, PhD, elected to the American Society for Clinical Investigation”
Category: People
Former SBP postdoc Louis Lapierre now assistant professor at Brown University
This is the first post in a series that will share what past SBP postdocs are doing now.
Louis Lapierre, PhD, was a postdoctoral researcher in the laboratory of Malene Hansen, PhD, associate professor in the Development, Aging, and Regeneration Program from 2008 to 2014, where he studied the molecular mechanisms of aging using the microscopic roundworm C. elegans. Since January 2015, he has been an assistant professor in the Department of Molecular Biology, Cell Biology, and Biochemistry at Brown University. His lab researches the role of lipophagy in aging, the process by which cells recycle fats to enhance longevity.
What did you gain from your postdoc experience at Sanford-Burnham? What was the best thing about doing science here?
Conducting research at Sanford-Burnham was a great stepping-stone in my career development. After my first publication there, because I was in a lab led by an emerging scientist, I had the flexibility to carry out research that I personally cared about, which led to interesting and unexpected findings. Eventually, I obtained independent financial support that was critical for my transition to independence. Importantly, SBP’s location in La Jolla means that it is surrounded by highly skilled researchers and state-of-the-art infrastructure, which makes for a cutting-edge, competitive environment.
How did you find your first job after your postdoc? Was it challenging?
I interviewed for several positions during the first half of 2014. The faculty job search is grueling, but I feel privileged to have gone through it. The main challenge is the outstanding level of competition not only at research-intensive institutions, but also at lower tier schools.
Why do you say participating in the faculty selection process was a privilege?
I think it’s easy to forget that our accomplishments were possible because, at some point, someone believed in us. Receiving support from colleagues and mentors and then being selected for interview by a search committee is a privilege that only a few postdocs get to experience.
What advice do you have for postdocs who hope to find a faculty position?
During your postdoc, plan meticulously to position yourself in line with funding opportunities and aggressively pursue emerging topics. During the job search, understand your value on the market, develop an interesting research program with long-term potential and strategically market yourself at conferences.
What do you enjoy most about your work and why?
I think the most fascinating part of basic research is the possibility of making new and exciting discoveries, and being at the forefront of knowledge. I also find mentoring highly rewarding because I get to make a difference in someone else’s life by building their confidence. This is especially gratifying when I get to work with students who have a passion for science, which is so important to thrive in this competitive environment.
What do you miss most about San Diego and why?
You only realize what you have when you lose it. Leaving San Diego was difficult because I knew nowhere else would be as good. I miss San Diego, not only for its incredible weather and beautiful beaches, but most importantly for the great friends I made there.
Gearing up for summer internships
Scientific staff at SBP’s Lake Nona campus are excited to welcome this year’s crop of high school interns in June. The highly competitive program—one of very few in Florida to offer such extensive hands-on research—received 48 applications from students for seven coveted slots. The majority of the academically talented, highly motivated students have taken advanced science coursework at area schools including Edgewater, Winter Park, Jones, East River, Trinity Prep, Timber Creek, Dr. Philips, Boone, Seminole and many others.
“We hope to provide transformative experiences—to immerse students in real, modern research using sophisticated techniques,” said Peter Crawford, MD, PhD, associate professor and director of the Cardiovascular Metabolism Program, who will oversee the internship program this year.
The interns will be involved in cutting-edge projects such as:
- Analyzing levels of thousands of types of fat molecules to identify possible biomarkers of early Alzheimer’s disease
- Using chemical profiling and mouse models to understand the metabolic origins of diabetes and heart disease
- Large-scale production of recombinant proteins using bioreactor systems
In their two to four weeks at SBP, trainees will work one-on-one with staff scientists and postdocs. In addition to lab training, they’ll be exposed to research from across the Institute through weekly seminars and discuss their work in lab meetings.
This involvement in the scientific community helps summer interns gain a lot more than knowledge of how to do experiments. Past intern Christina Lee, now a sophomore at UCLA preparing for medical school, reflected that she acquired “an invaluable perspective on how quickly the scientific community is moving forward.”
“What surprised me most in the lab,” said intern Mitchell Thomas, “is the unwavering motivation researchers have. Though some procedures are very time consuming and may not work the first time, they continue on.”
Appreciating the pace of scientific progress and the rigors of laboratory research will be a great benefit for these students, who plan to pursue life science careers. The 50 SBP Lake Nona internship alumni are now pursuing higher education at such prestigious universities as Duke, Stanford, the University of Florida, and the University of Pennsylvania.
Mirco Guigli graduates SBP’s PhD program, will continue project at Vala Sciences
Mirco Guigli, who defended his PhD thesis on February 25, represents another success for SBP’s graduate program. He not only developed a prototype microscope that has generated commercial interest, but has a clear plan for his future—he will join Vala Sciences to continue this work.
Guigli knew before coming to SBP that he intended to work in industry, which made him a good fit for the laboratory of Jeffrey Price, MD, PhD, an associate professor here and president and CEO of Vala. Price’s lab develops high-performance imaging technologies to support drug screening.
When asked how he decided on SBP for his graduate training, Guigli explained, “Jeff contacted me and suggested I come back to his lab to do a PhD—I had done an internship with him in 2009 as part of my masters program. I was actually pretty happy where I was, working as an electrical engineer designing a dialysis machine for a company in Italy, but I was 25 and had nothing to lose.”
His background in engineering was helpful for Guigli’s project, in which he designed, built, and adapted software for a microscope that offers a promising alternative to confocal microscopy. This system offers similar resolution to confocal, but takes up much less space and uses less intense illumination, allowing imaging of biological processes in real time.
This high resolution is possible because the microscope employs structured illumination, in which portions of the specimen are illuminated in sequential complementary grid patterns. While this approach has already been employed in commercially available microscopes, the key to this new system is the use of a digital micromirror (also used in IMAX projection) to control which parts of the specimen are illuminated. Because digital micromirrors are not microscopic, they’re easier to synchronize with image collection, which could make this microscope faster than what’s currently available.
While this project, focusing on technology rather than biology, is unusual for SBP, Guigli greatly values the knowledge he gained. “I was basically learning what a protein was at age 27. My fellow students, who mostly had experience in biological research, were really helpful. As we were discussing our projects over beers, they really wanted to help me understand their work. From those discussions, I also got a feel for biology as a whole, since they’re working on everything from HIV to muscle regeneration to Alzheimer’s.”
SBP scientists join race for a cure
Andrew Carley, PhD, has a personal motivation for finding a cure for diabetes. As one of the 29 million Americans with diabetes, he became a biomedical researcher to better understand the causes of disease.
For Julio Ayala, PhD, a passion for medical research was sparked by his grandmother, a type 1 diabetic, who at age 86 has successfully managed the disease most of her life.
Siobhan Malany, PhD, is an avid cyclist who believes so strongly in team efforts that she has enlisted robots to join her research team searching for new drugs to fight disease.
On Sunday, March 13, 2016, these Sanford Burnham Prebys scientists took their interest in biomedical research to the roadways of Central Florida as they joined 1,100 participants in the 2016 Tour de Cure at Lake Nona bicycle ride for diabetes. The twelve-member SBP team collectively pedaled more than 400 miles and raised $9,000 to fight the disease. Participants began the 25, 63, and 100-mile courses in Lake Nona Medical City near SBP and the Center for Metabolic Origins of Disease, the site where researchers study diabetes in hopes of identifying new, more effective therapies.
“It was a fun way to give back and do what I love to do. Cycling has been my commute, my sport and my escape —now it’s a way to contribute,” said Malany, who completed the 100-mile course in five hours. She enjoyed the camaraderie and credited the group with a bit of competitive motivation. “I kept a 21.5 mile per hour pace, which was not something I would have accomplished had I been cycling alone. It was fast and fun being in a pack because you conserve energy by drafting,” added Malany.
Since moving to Lake Nona in December from Chicago, Carley has gotten back into cycling and now bikes to the Institute in Medical City each day. He completed a Century ride to mark the 20th anniversary of the Tour de Cure in 2011 in Chicago and decided to mark the 25th anniversary of the event with a 25 mile ride. “I selected the 25 mile course because it was the maximum length of time my 3-year old daughter would remain content in her bike stroller watching a Toy Story movie. She weighs only 32 pounds and the course was relatively flat so we were able to complete the ride in two hours despite frequent stops,” said Carley.
Team captain Ayala participated in various ADA and JDRF fund raising events while at Vanderbilt University. “While riding my bike to work a few years ago, I saw the first Tour de Cure in Lake Nona and knew that I wanted to participate. We study diseases of metabolism at the Medical City site and a number of faculty, including me, receive ADA-funded grants, so I wanted to get involved,” said Ayala.
Ayala credits the team’s spirit with providing extra motivation to push through the extreme winds encountered on the course. It’s with similar determination that they approach their daily race for the cure in their research labs.
SBP helps students “worm” up to science at STEM Expo
On Saturday, March 5, a keen group of SBP volunteers hauled wagons of lab coats, mutant worms and magnifying glasses to give the next generation of scientists—mainly kids in grades K-8—an opportunity to see first-hand how tiny worms named C. elegans are used to understand the aging process.
Renowned biochemist, Marcia I. Dawson, has died
Marcia I. Dawson, whose pioneering research helped lay the groundwork for pro-apoptotic (programmed cell death) small molecules for the treatment of cancer, died recently at her home in Menlo Park, California. Continue reading “Renowned biochemist, Marcia I. Dawson, has died”
SBP graduate student Victoria Thaney’s internship at Illumina
Congratulations to Victoria Thaney, who was chosen for an internship at Illumina, a leader in developing sequencing technologies that was named the world’s smartest company by MIT Technology Review in 2014. She was recently interviewed about her experience by Alexia Pimentel, SBP’s graduate program coordinator. Continue reading “SBP graduate student Victoria Thaney’s internship at Illumina”
Randal Kaufman among world’s most influential biologists
Thomson Reuters has announced the world’s most influential scientific minds, and for the second time since 2014, Randal Kaufman, Ph. D., professor and director of SBP’s Degenerative Disease Program, is on that list. Thomson Reuters created the list based on scientists who write the most reports that rank among the top 1 percent cited by other scientists between the years 2003 and 2013. Analysts looked at more than 120,000 papers and recognized close to 3000 scientists.
Continue reading “Randal Kaufman among world’s most influential biologists”
Psoriasis research event at SBP brings together patients, clinicians, and scientists
It was a night of learning, sharing and making connections. The 60+ people who came to the psoriasis research update at SBP on February 2 all had something in common: psoriasis has affected their lives in some way. Continue reading “Psoriasis research event at SBP brings together patients, clinicians, and scientists”