Alexandre Colas' Research Focus
Our laboratory focuses on the identification and reconstruction of novel regulatory pathways controlling the determination and the acquisition of cardiovascular cell fates in humans. To that end, our team has developed a unique set of cell-based assays suitable for high-throughput functional screening, which enables the implementation of unbiased and systematic experimental approaches with unprecedented exploratory power. Our goal is to leverage generated knowledge to produce better cardiomyocytes to model cardiac diseases in-a-dish as well as to devise innovative cardiac regenerative strategies. In parallel, our lab is also dedicated to identify and develop new drugs promoting cardiac regeneration and/or helping preserving heart function after injury.
Alexandre Colas' Bio
Dr. Colas earned his Ph.D. from the Universite Pierre et Marie Curie, Paris, France.
Funding Awards and Collaborative Grants
2011-2013: American Heart Association Post-Doctoral Fellowship
2011: Best Talk Award (Development & Aging Post-Doctoral Retreat, SBP)
2010-2011: California Institute for Regenerative Medicine Post-Doctoral Fellowship
2006-2007: French Myopathy Association Ph.D. Fellowship
2003-2006: Ministry of French Research Ph.D. Fellowship
2000-2001: Erasmus Undergraduate Fellowship
Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.
Cunningham TJ, Brade T, Sandell LL, Lewandoski M, Trainor PA, Colas A, Mercola M, Duester G
PLoS One 2015 ;10(9):e0137894
Mercola M, Colas A, Willems E
Circ Res 2013 Feb 1 ;112(3):534-48
Serum-free generation of multipotent mesoderm (Kdr+) progenitor cells in mouse embryonic stem cells for functional genomics screening.
McKeithan WL, Colas AR, Bushway PJ, Ray S, Mercola M
Curr Protoc Stem Cell Biol 2012 Nov ;Chapter 1:Unit 1F.13
Bruyneel AAN, Colas AR, Karakikes I, Mercola M
PLoS One 2019 ;14(12):e0226694
Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld JA, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R
Hum Mol Genet 2019 Dec 1 ;28(23):3954-3969
Generation of First Heart Field-like Cardiac Progenitors and Ventricular-like Cardiomyocytes from Human Pluripotent Stem Cells.
Yu MS, Spiering S, Colas AR
J Vis Exp 2018 Jun 19 ;(136)
Acellular therapeutic approach for heart failure: in vitro production of extracellular vesicles from human cardiovascular progenitors.
El Harane N, Kervadec A, Bellamy V, Pidial L, Neametalla HJ, Perier MC, Lima Correa B, Thiébault L, Cagnard N, Duché A, Brunaud C, Lemitre M, Gauthier J, Bourdillon AT, Renault MP, Hovhannisyan Y, Paiva S, Colas AR, Agbulut O, Hagège A, Silvestre JS, Menasché P, Renault NKE
Eur Heart J 2018 May 21 ;39(20):1835-1847
An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M
Front Physiol 2017 ;8:766
Cunningham TJ, Yu MS, McKeithan WL, Spiering S, Carrette F, Huang CT, Bushway PJ, Tierney M, Albini S, Giacca M, Mano M, Puri PL, Sacco A, Ruiz-Lozano P, Riou JF, Umbhauer M, Duester G, Mercola M, Colas AR
Genes Dev 2017 Jul 1 ;31(13):1325-1338