Andrey Bobkov, Ph.D.
Andrey Bobkov's Research Focus
Dr. Andrey Bobkov scientific interests include
- Applications of biophysical methods to characterize protein structural and functional properties in vitro. In particular, protein folding and stability, self- and hetero- association, and mechanisms of protein interaction with ligands, small molecules and inhibitors.
- Protein synthesis, folding and post translational processing in prokaryotic and eukaryotic cells.
- Implementation and development of protein purification and fractionation methods.
Andrey Bobkov's Bio
Andrey A. Bobkov, Director, Protein Production and Analysis, leads the Prebys Center effort on recombinant protein production and biophysical characterization. He has received an M.S. in Biochemistry from Moscow State University (Russia) and a Ph.D. in Biochemistry from the Bach Institute of Biochemistry of Russian Academy of Sciences. Andrey did his postdoctoral training at UCLA Chemistry and Biochemistry Department. Andrey has more than 20 years of experience and over 40 publications in the field of Biophysical Analysis. He teaches the Protein Analysis and Biophysics portion of the Structural Biology in Cell Signaling and Drug Discovery Course to Sanford Burnham Prebys graduate students.
Publications
Conformation of BCL-XL upon Membrane Integration.
Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM
J Mol Biol 2015 Jul 3 ;427(13):2262-70
Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI
Medchemcomm 2013 Feb 1 ;4(2):332-339
αE-catenin is an autoinhibited molecule that coactivates vinculin.
Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI
Proc Natl Acad Sci U S A 2012 May 29 ;109(22):8576-81
Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis.
Lu J, Rahman MI, Kazan IC, Halloran NR, Bobkov AA, Ozkan SB, Ghirlanda G
Protein Sci 2023 Sep ;32(9):e4759
Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).
Lambert LJ, Grotegut S, Celeridad M, Gosalia P, Backer LJ, Bobkov AA, Salaniwal S, Chung TD, Zeng FY, Pass I, Lombroso PJ, Cosford ND, Tautz L
Int J Mol Sci 2021 Apr 23 ;22(9)
Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Aleshin AE, Yao Y, Iftikhar A, Bobkov AA, Yu J, Cadwell G, Klein MG, Dong C, Bankston LA, Liddington RC, Im W, Powis G, Marassi FM
Structure 2021 Sep 2 ;29(9):1029-1039.e3
Local Interactions That Contribute Minimal Frustration Determine Foldability.
Zou T, Woodrum BW, Halloran N, Campitelli P, Bobkov AA, Ghirlanda G, Ozkan SB
J Phys Chem B 2021 Mar 18 ;125(10):2617-2626
Conformational States of the Cytoprotective Protein Bcl-xL.
Ryzhov P, Tian Y, Yao Y, Bobkov AA, Im W, Marassi FM
Biophys J 2020 Oct 6 ;119(7):1324-1334
Structurally plastic NEMO and oligomerization prone IKK2 subunits define the behavior of human IKK2:NEMO complexes in solution.
Ko MS, Biswas T, Mulero MC, Bobkov AA, Ghosh G, Huxford T
Biochim Biophys Acta Proteins Proteom 2020 Dec ;1868(12):140526
