Andrey Bobkov, Ph.D.

Andrey Bobkov, headshot

Andrey Bobkov, Ph.D.

Director, Protein Production and Analysis

Andrey Bobkov's Research Focus

Cell Biology, Analytical Biophysics, Protein Chemistry
Protein Structure-Function Relationships
General Cell Biology
Bacteria, Cultured Cell Lines, Human Cell Lines, Insect Cell Lines
Biochemistry

Dr. Andrey Bobkov scientific interests include

  • Applications of biophysical methods to characterize protein structural and functional properties in vitro. In particular, protein folding and stability, self- and hetero- association, and mechanisms of protein interaction with ligands, small molecules and inhibitors.
  • Protein synthesis, folding and post translational processing in prokaryotic and eukaryotic cells.
  • Implementation and development of protein purification and fractionation methods.

Andrey Bobkov's Bio

Andrey A. Bobkov, Director, Protein Production and Analysis, leads the Prebys Center effort on recombinant protein production and biophysical characterization. He has received an M.S. in Biochemistry from Moscow State University (Russia) and a Ph.D. in Biochemistry from the Bach Institute of Biochemistry of Russian Academy of Sciences. Andrey did his postdoctoral training at  UCLA Chemistry and Biochemistry Department. Andrey has more than 20 years of experience and over 40 publications in the field of Biophysical Analysis. He teaches the Protein Analysis and Biophysics portion of the Structural Biology in Cell Signaling and Drug Discovery Course to Sanford Burnham Prebys graduate students.


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Publications

Conformation of BCL-XL upon Membrane Integration.

Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM

J Mol Biol 2015 Jul 3 ;427(13):2262-70

Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.

Xia Z, Cao X, Rico-Bautista E, Yu J, Chen L, Chen J, Bobkov A, Wolf DA, Zhang XK, Dawson MI

Medchemcomm 2013 Feb 1 ;4(2):332-339

αE-catenin is an autoinhibited molecule that coactivates vinculin.

Choi HJ, Pokutta S, Cadwell GW, Bobkov AA, Bankston LA, Liddington RC, Weis WI

Proc Natl Acad Sci U S A 2012 May 29 ;109(22):8576-81

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Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.

Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD

Res Sq 2024 Feb 23 ;

Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.

Mealka M, Sierra NA, Matteo DA, Albekioni E, Khoury R, Mai T, Conley BM, Coleman NJ, Sabo KA, Komives EA, Bobkov AA, Cooksy AL, Silletti S, Schiffer JM, Huxford T, Sohl CD

bioRxiv 2024 Jan 23 ;

Engineering gain-of-function mutants of a WW domain by dynamics and structural analysis.

Lu J, Rahman MI, Kazan IC, Halloran NR, Bobkov AA, Ozkan SB, Ghirlanda G

Protein Sci 2023 Sep ;32(9):e4759

Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP).

Lambert LJ, Grotegut S, Celeridad M, Gosalia P, Backer LJ, Bobkov AA, Salaniwal S, Chung TD, Zeng FY, Pass I, Lombroso PJ, Cosford ND, Tautz L

Int J Mol Sci 2021 Apr 23 ;22(9)

Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.

Aleshin AE, Yao Y, Iftikhar A, Bobkov AA, Yu J, Cadwell G, Klein MG, Dong C, Bankston LA, Liddington RC, Im W, Powis G, Marassi FM

Structure 2021 Sep 2 ;29(9):1029-1039.e3

Local Interactions That Contribute Minimal Frustration Determine Foldability.

Zou T, Woodrum BW, Halloran N, Campitelli P, Bobkov AA, Ghirlanda G, Ozkan SB

J Phys Chem B 2021 Mar 18 ;125(10):2617-2626

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