Anindya Bagchi's Research Focus
My lab studies the genetic mutations that drive cancer. I am a geneticist by training, and I am passionate about finding the hidden drivers of cancer. As a research community, we have made tremendous progress in the last few decades in understanding the nature of the beast, but now is the time to translate those knowledge to actionable interventions. A riveting idea that has excited us for sometime is to illuminate the genetic mutations which act as life line to many cancers. This would expose their Achilles heel that we can exploit in near future to develop new forms of treatment. That is what my lab’s work is focused on. We have identified and characterized several key mutations that we have shown as proof of concept can be targeted in as much as 30% of all cancers. The focus of the lab is now to carry out experiments that will allow us to develop this work beyond the proof of concept, ideally to successful clinical trials.
Anindya Bagchi's Bio
Dr. Bagchi comes to SBP from the University of Minnesota, where he has been since 2008, having earlier held positions as assistant professor of Cell Biology & Development (Genetic Mechanism of Cancer) and Co-Director of Mouse Genetics Laboratory at University of Minnesota. Dr. Bagchi brings his lab with him and an established research program in genetic mechanisms of cancer. He completed his Ph.D. degree at Jawaharlal Nehru University in New Delhi, India and then worked as a postdoctoral fellow at the Cold Spring Harbor Laboratory in New York. He has been an American Cancer Society Research Scholar since 2014 and Masonic Scholar since 2010.
Tseng YY, Moriarity BS, Gong W, Akiyama R, Tiwari A, Kawakami H, Ronning P, Reuland B, Guenther K, Beadnell TC, Essig J, Otto GM, O'Sullivan MG, Largaespada DA, Schwertfeger KL, Marahrens Y, Kawakami Y, Bagchi A
Nature 2014 Aug 7 ;512(7512):82-6
Bagchi A, Papazoglu C, Wu Y, Capurso D, Brodt M, Francis D, Bredel M, Vogel H, Mills AA
Cell 2007 Feb 9 ;128(3):459-75
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA
Nat Genet 2008 Jun ;40(6):751-60
Structure based virtual screening of natural products to disrupt the structural integrity of TRAF6 C-terminal domain homotrimer.
Biswas R, Chowdhury N, Biswas S, Roy R, Bagchi A
J Mol Graph Model 2019 Aug 29 ;93:107428
Insight into the binding of a synthetic nitro-flavone derivative with human poly (ADP-ribose) polymerase 1.
Mitra A, Biswas R, Bagchi A, Ghosh R
Int J Biol Macromol 2019 Aug 29 ;141:444-459
Longer collagen fibers trigger multicellular streaming on soft substrates via enhanced forces and cell-cell cooperation.
Sarker B, Bagchi A, Walter C, Almeida J, Pathak A
J Cell Sci 2019 Aug 23 ;
Blueberry extract attenuates doxorubicin-induced damage in H9c2 cardiac cells <sup>1</sup>.
Sun Y, Nemec-Bakk AS, Mallik AU, Bagchi AK, Singal PK, Khaper N
Can J Physiol Pharmacol 2019 Sep ;97(9):880-884
Network analysis of hyphae forming proteins in <i>Candida albicans</i> identifies important proteins responsible for pathovirulence in the organism.
Das S, Bhuyan R, Bagchi A, Saha T
Heliyon 2019 Jun ;5(6):e01916
Role of redox imbalance and cytokines in mediating oxidative damage and disease progression of patients with rheumatoid arthritis.
Pradhan A, Bagchi A, De S, Mitra S, Mukherjee S, Ghosh P, Ghosh A, Chatterjee M
Free Radic Res 2019 Jul ;53(7):768-779