Darren "Ben" Finlay, Ph.D.

Finlay

Darren "Ben" Finlay, Ph.D.

Research Assistant Professor
Scientific Director

Darren "Ben" Finlay's Research Focus

Brain Cancer, Breast Cancer, Pancreatic Cancer, Skin Cancer and Melanoma, Leukemia/Lymphoma, Lung Cancer

Dr. Finlay's research is focused on apoptosis (programmed cell death) and how this process can be manipulated to kill cancer cells.

Darren "Ben" Finlay's Bio

Education

University College Dublin
B.Sc. and Ph.D., Pharmacology, cell and molecular biology, signal transduction and cancer, First Class Honors

 


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Publications

Novel HTS strategy identifies TRAIL-sensitizing compounds acting specifically through the caspase-8 apoptotic axis.

Finlay D, Richardson RD, Landberg LK, Howes AL, Vuori K

PLoS One 2010 Oct 12 ;5(10):e13375

Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.

Cipres A, O'Malley DP, Li K, Finlay D, Baran PS, Vuori K

ACS Chem Biol 2010 Feb 19 ;5(2):195-202

Caspase-8 as a potential mediator of pro-tumorigenic signals.

Finlay D, Howes A, Vuori K

Cell Cycle 2009 Nov 1 ;8(21):3441-2

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Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients.

Ding KF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ

Front Genet 2018 ;9:228

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.

Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M

Chem Sci 2018 Feb 28 ;9(8):2113-2129

Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis.

Ding KF, Petricoin EF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ

Oncotarget 2018 Jan 12 ;9(4):5044-5057

Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation.

Bell JB, Eckerdt F, Dhruv HD, Finlay D, Peng S, Kim S, Kroczynska B, Beauchamp EM, Alley K, Clymer J, Goldman S, Cheng SY, James CD, Nakano I, Horbinski C, Mazar AP, Vuori K, Kumthekar P, Raizer J, Berens ME, Platanias LC

Mol Cancer Res 2018 Jan ;16(1):32-46

Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.

Finlay D, Teriete P, Vamos M, Cosford NDP, Vuori K

F1000Res 2017 ;6:587

Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses.

Ding KF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ

Oncotarget 2017 Apr 25 ;8(17):27786-27799

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