Duc Dong, Ph.D.
Lab Website
Duc Dong's Research Focus
Our objective is to uncover fundamental insight into basic and biomedical science through rigorous investigation of the genetic mechanisms governing organogenesis and diseases. We have discovered multiple genes critical for generating liver and pancreas cells and have created novel animal models for diseases such as diabetes and Alagille Syndrome. These unique experimental models have been yielded mechanistic insight and potential new therapeutic avenues. Further, we have demonstrated for the first time that a cell’s identity can be reprogrammed to convert into a completely unrelated lineage, without their removal from the body (in vivo) and without passage through a stem cell intermediate. This in vivo lineage reprogramming breakthrough may lead to a vast new and safer source of replacement cells for degenerative diseases and injuries. Ultimately, we aim to develop genetic technologies to improve human health and advance human biology.
with a mutation in jagged, the gene affected in his disease.
Duc Dong's Bio
Dr. Dong received his Biology Bachelor of Science degree in 1996 from the University of California, Irvine, where he was involved in molecular evolution and limb regeneration research. He earned his Ph.D. in Cell and Molecular Biology at the University of Wisconsin, Madison in 2002, investigating cell/tissue identity master regulatory genes. His postdoctoral research at the University of California, San Francisco was focused on developmental genetics of the liver and pancreas. Dr. Dong was recruited as an Assistant Professor to Sanford Burnham Prebys Medical Discovery Institute in 2008. He is a recipient of the NIH Director’s New Innovator Award Award and the W. M. Keck Foundation Award, which funds the development of in vivo lineage reprogramming technologies to generate replacement cells and organs directly within a living vertebrate.
Education
University of California, Irvine, B.S., Biology
University of Wisconsin, Madison, Ph.D., Cell & Molecular Biology
University of California, San Francisco, Postdoctoral Fellow, Genetics and Development
Publications
Endoderm Jagged induces liver and pancreas duct lineage in zebrafish.
Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump JG, Dong PDS
Nat Commun 2017 Oct 3 ;8(1):769
Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival.
Zhang D, Golubkov VS, Han W, Correa RG, Zhou Y, Lee S, Strongin AY, Dong PD
Dev Biol 2014 Nov 1 ;395(1):96-110
Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb.
Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD
Development 2013 Jul ;140(13):2669-79
Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDS, Gaulton KJ, Sander M
Elife 2021 Feb 5 ;10
Lineage analysis reveals an endodermal contribution to the vertebrate pituitary.
Fabian P, Tseng KC, Smeeton J, Lancman JJ, Dong PDS, Cerny R, Crump JG
Science 2020 Oct 23 ;370(6515):463-467
A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development.
Helker CSM, Mullapudi ST, Mueller LM, Preussner J, Tunaru S, Skog O, Kwon HB, Kreuder F, Lancman JJ, Bonnavion R, Dong PDS, Looso M, Offermanns S, Korsgren O, Spagnoli FM, Stainier DYR
Development 2019 Jul 24 ;146(14)
Mouse but not zebrafish requires retinoic acid for control of neuromesodermal progenitors and body axis extension.
Berenguer M, Lancman JJ, Cunningham TJ, Dong PDS, Duester G
Dev Biol 2018 Sep 1 ;441(1):127-131
Genomic Knockout of Two Presumed Forelimb Tbx5 Enhancers Reveals They Are Nonessential for Limb Development.
Cunningham TJ, Lancman JJ, Berenguer M, Dong PDS, Duester G
Cell Rep 2018 Jun 12 ;23(11):3146-3151
RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis.
Wu XL, Yang ZW, He L, Dong PD, Hou MX, Meng XK, Zhao HP, Wang ZY, Wang F, Baoluri, Wurenqimuge, Agudamu, Jia YF, Shi L
Oncotarget 2017 Oct 10 ;8(47):82968-82980