Karen Ocorr, Ph.D.
Lab Website
Karen Ocorr's Research Focus
The Ocorr Lab is investigating the cellular and molecular basis of adult heart function and cardiomyopathies using the genetic model system Drosophila.
We use functional, electrophysiological, biochemical and immunohistochemical techniques that allow us to examine the roles of genes and gene products in cardiac channelopathies and stress-related cardiomyopathies.
Our lab pioneered the development of a novel methodology (Semi-automatic Optical Heartbeat Analysis, SOHA) that permits the quantification of heartbeat parameters in model systems with small hearts.
Using this system we have identified several ion channels in the fly heart that play prominent roles in repolarization of the human heart and cause arrhythmia in both the fly and in humans when mutated. We also have developed a number of other disease models including a diabetic-like cardiomyopathy induced by high sugar diet and hypoxia-induced cardiomyopathy.
Recently we have begun collaborations with NASA (by winning a Space Florida International Space Station Research Competition). We are using the fly to uncover the molecular/cellular basis for cardiac and muscle atrophy in astronauts exposed to extended periods of microgravity despite extensive exercise regimes aboard the ISS. Our flies were launched aboard SpaceX 3 for a month-long exposure to micro-gravity.
Karen Ocorr's Research Report
My lab is working to understand the cellular and molecular basis of heart disease. One project is focused on the genetic basis of Atrial Fibrillation. This project is a collaborative one with the lab of Alexandre Colas. We are combining two model systems, the fly in my lab and human induced cardiomyocytes in his lab, to identify AFib genes that have been implicated from patient studies. Another project focuses on the role of metabolism in cardiomyopathies. This is because obesity and metabolic syndrome are linked to an increased risk of heart disease. We are studying the role of a key metabolic signaling molecule in hypertrophic cardiomyopathy. A separate effort is focused on the role of gravity in heart function. These studies will provide important information for future habitants of colonies on the moon and Mars. But they are also relevant to patients who are bedridden and to patients with muscle wasting (sarcopenia).
Karen Ocorr's Bio
After a successful teaching career at the University of Michigan I have had the privilege to "reboot" my research career at Sanford Burnham Prebys where I have had the opportunity to develop novel methodologies to understand cardiomyopathy. I have also had the opportunity to work with NASA scientists to do experiments on the International Space Station.
Education
Postdoctoral Fellow, Stanford University, Palo Alto, CA, Neurochemistry
Postdoctoral Fellow, University of Texas Medical School, Houston, TX, Neuroscience NIMH
Ph.D., Wesleyan University, Middletown, CT, Neuroscience NIMH
B.A., Lehigh University, Bethlehem, PA, Biology
Prestigious Runding Awards or Major Collaborative Grants
2015-2020: NIH R01 HL132241-01A1 - Using Drosophila genetics to identify molecular links between ion channel dysfunction and pathological cardiac remodeling. (PI) 2013-2018 NASA NRA #NNH12ZTT001N – The effects of microgravity on cardiac function, structure and gene expression using the Drosophila model. (Co-I)
Honor and Awards
2014: Space Florida International Space Station Research Competition Winner – Co-investigator - One of three Basic Research proposals selected for launch aboard SpaceX3 - Mission completed, live flies returned on May 18,2014
2001: Excellence in Teaching Award, University of Michigan
1997: Excellence in Teaching Award, University of Michigan
1986-1988: National Institute of Mental Health Fellowship
1983-1985: National Institute of Mental Health Fellowship
1981: Sigma Xi Research Award 1980 MBL Scholarship, Neural Systems and Behavior Course
1971-1975: National Merit Scholarship, Lehigh University
Board Appointments
2018-present: Board member American Society for Gravitational and Space Research
Publications
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila.
Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K
Cell Rep 2020 Dec 8 ;33(10):108445
A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts.
Fink M, Callol-Massot C, Chu A, Ruiz-Lozano P, Izpisua Belmonte JC, Giles W, Bodmer R, Ocorr K
Biotechniques 2009 Feb ;46(2):101-13
Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations.
Ocorr K, Zambon A, Nudell Y, Pineda S, Diop S, Tang M, Akasaka T, Taylor E
PLoS Genet 2017 May ;13(5):e1006786
Deacetylase-dependent and -independent role of HDAC3 in cardiomyopathy.
Ren J, Zeng Q, Wu H, Liu X, Guida MC, Huang W, Zhai Y, Li J, Ocorr K, Bodmer R, Tang M
J Cell Physiol 2023 Mar ;238(3):647-658
Genetic architecture of natural variation of cardiac performance from flies to humans.
Saha S, Spinelli L, Castro Mondragon JA, Kervadec A, Lynott M, Kremmer L, Roder L, Krifa S, Torres M, Brun C, Vogler G, Bodmer R, Colas AR, Ocorr K, Perrin L
Elife 2022 Nov 16 ;11
Resveratrol Microencapsulation into Electrosprayed Polymeric Carriers for the Treatment of Chronic, Non-Healing Wounds.
De Pieri A, Ocorr K, Jerreld K, Lamoca M, Hitzl W, Wuertz-Kozak K
Pharmaceutics 2022 Apr 13 ;14(4)
Atrial Fibrillation Genomics: Discovery and Translation.
Yoo DH, Bodmer R, Ocorr K, Larson CJ, Colas AR, Muse ED
Curr Cardiol Rep 2021 Oct 1 ;23(11):164
Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, K(Ca)1.1, in Sinus Node Function and Arrhythmia Risk.
Pineda S, Nikolova-Krstevski V, Leimena C, Atkinson AJ, Altekoester AK, Cox CD, Jacoby A, Huttner IG, Ju YK, Soka M, Ohanian M, Trivedi G, Kalvakuri S, Birker K, Johnson R, Molenaar P, Kuchar D, Allen DG, van Helden DF, Harvey RP, Hill AP, Bodmer R, Vogler G, Dobrzynski H, Ocorr K, Fatkin D
Circ Genom Precis Med 2021 Apr ;14(2):e003144
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila.
Walls S, Diop S, Birse R, Elmen L, Gan Z, Kalvakuri S, Pineda S, Reddy C, Taylor E, Trinh B, Vogler G, Zarndt R, McCulloch A, Lee P, Bhattacharya S, Bodmer R, Ocorr K
Cell Rep 2020 Dec 8 ;33(10):108445
