Maximiliano D'Angelo, Ph.D.

Maximiliano D'Angelo's Research Focus

Aging-Related Diseases

A hallmark of eukaryotic cells is that the genome is enclosed by the Nuclear Envelope (NE), a double lipid bilayer that physically separates the nuclear interior from the cytoplasm. The NE is penetrated by large multiprotein channels known Nuclear Pore Complexes or NPCs. Historically, NPCs were considered static structures whose main and only function was to control the exchange of molecules between the nucleus and the cytoplasm. But this simplistic view of the NPC is now changing, as it has become evident that NPCs are highly dynamic complexes with many transport-independent functions such as chromatin organization, gene expression regulation and the control of cell fate. The main focus of our laboratory is to study the role of nuclear pore complexes in nuclear organization, cell differentiation, aging and disease.

Maximiliano D'Angelo's Bio

Dr. D’Angelo earned his B.S. and M.S. degrees in chemistry at the University of Cordoba, Argentina, and his Ph.D. in biochemistry and molecular biology from University of Buenos Aires. He then trained as a postdoctoral fellow in cell biology at The Salk and the Scripps Research Institute in San Diego. In 2011, Dr. D’Angelo was appointed as an Assistant Professor of the Biochemistry and Biophysics department and a Principal Investigator of the Cardiovascular Research Institute at the University of California San Francisco. In 2012, he was named Scholar of the Pew Charitable Trust. Dr. D’Angelo was recruited the to the Development, Aging and Regenerative Program at Sanford Burnham Prebys in October 2014.

 

Funding awards and collaborative grants

Pew Charitable Trust Scholar in Biomedical Sciences


DAR Accessory

Publications

Nuclear pore complexes and regulation of gene expression.

Raices M, D'Angelo MA

Curr Opin Cell Biol 2017 Jun ;46:26-32

Linking Nucleoporins, Mitosis, and Colon Cancer.

Wong RW, D'Angelo M

Cell Chem Biol 2016 May 19 ;23(5):537-539

Nup62: a novel regulator of centrosome integrity and function.

Borlido J, D'Angelo MA

Cell Cycle 2014 ;13(1):14

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Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4<sup>+</sup> T cell homeostasis.

Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley LM, D'Angelo MA

Nat Immunol 2018 Jun ;19(6):594-605

Nup62-mediated nuclear import of p63 in squamous cell carcinoma.

Borlido J, D'Angelo MA

EMBO Rep 2018 Jan ;19(1):3-4

Nuclear pore complexes as hubs for gene regulation.

D'Angelo MA

Nucleus 2018 Jan 1 ;9(1):142-148

Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex.

Raices M, Bukata L, Sakuma S, Borlido J, Hernandez LS, Hart DO, D'Angelo MA

Dev Cell 2017 Jun 5 ;41(5):540-554.e7

The roles of the nuclear pore complex in cellular dysfunction, aging and disease.

Sakuma S, D'Angelo MA

Semin Cell Dev Biol 2017 Aug ;68:72-84

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