Rolf Bodmer, Ph.D.
Lab Website
Rolf Bodmer's Research Focus
The Bodmer Laboratory is interested in the molecular mechanisms of organ formation, how patterns are generated and how cells and tissue types assume their correct fates and functions. The Bodmer lab is pursuing this interest by studying the genetic functions and interactions that specify heart development and maintain heart performance in the Drosophila model, in the hope of elucidating basic principles in organogenesis and functionality.
Mesoderm
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Cardiac Mesoderm
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Cardiac Cell Types
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Morphogenesis
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Heart Function
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Aging Heart
We study the HIF and Notch pathways in various organismal responses to hypoxia. Both of these pathways as well as mechanisms and responses to hypoxia are of high relevance to cancer research.
We are also studying master regulatory networks in how they control metabolism and obesity. These fundamental studies on obesity pathways will also be highly relevant to cancer metabolism.
Rolf Bodmer's Bio
Rolf Bodmer earned his Ph.D. in Biochemistry and Neurobiology from the University of Basel, Switzerland, in 1983. Dr. Bodmer trained as a postdoctoral fellow in Neurobiology at the Albert Einstein College of Medicine in New York, and also studied Molecular Genetics at the University of California, San Francisco. He was appointed Assistant Professor of Biology in 1990 at the University of Michigan. There, he was promoted to Associate Professor of Biology in 1996, and then appointed to Associate Professor of Molecular, Cellular and Developmental Biology in 2001. Dr. Bodmer joined SBP in 2003, where he is Professor and Program Director of the Development, Aging, and Regeneration Program.
Other Appointments
Adjunct professor, University of California, San Diego
Funding Awards and Collaborative Grants
1 P01 AG033561 "Genetic Analysis of Drosophila Functional Aging"
Honors and Recognition
Ellison Foundation Senior Scholar Award
Publications
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R
J Cell Biol 2011 Jun 27 ;193(7):1181-96
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.
Birse RT, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, Ocorr K, Bodmer R, Oldham S
Cell Metab 2010 Nov 3 ;12(5):533-44
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM
Cell 2010 Apr 2 ;141(1):142-53
Silencing of CCR4-NOT complex subunits affect heart structure and function.
Elmén L, Volpato CB, Kervadec A, Pineda S, Kalvakuri S, Alayari NN, Foco L, Pramstaller PP, Ocorr K, Rossini A, Cammarato A, Colas AR, Hicks AA, Bodmer R
Dis Model Mech 2020 May 29 ;
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Chang K, Kang P, Liu Y, Huang K, Miao T, Sagona AP, Nezis IP, Bodmer R, Ocorr K, Bai H
Autophagy 2019 Dec 29 ;:1-16
Model system identification of novel congenital heart disease gene candidates: focus on RPL13.
Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld JA, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R
Hum Mol Genet 2019 Dec 1 ;28(23):3954-3969
Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila.
Guida MC, Birse RT, Dall'Agnese A, Toto PC, Diop SB, Mai A, Adams PD, Puri PL, Bodmer R
Nat Commun 2019 Jan 14 ;10(1):193
Corrigendum: SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila.
Zanon A, Kalvakuri S, Rakovic A, Foco L, Guida M, Schwienbacher C, Serafin A, Rudolph F, Trilck M, Grünewald A, Stanslowsky N, Wegner F, Giorgio V, Lavdas AA, Bodmer R, Pramstaller PP, Klein C, Hicks AA, Pichler I, Philip S
Hum Mol Genet 2019 Apr 1 ;28(7):1225
As time flies by: Investigating cardiac aging in the short-lived Drosophila model.
Blice-Baum AC, Guida MC, Hartley PS, Adams PD, Bodmer R, Cammarato A
Biochim Biophys Acta Mol Basis Dis 2019 Jul 1 ;1865(7):1831-1844