Yasuyuki Kihara, Ph.D.

Yasuyuki Kihara Profile

Yasuyuki Kihara, Ph.D.

Research Associate Professor

Yasuyuki Kihara's Research Focus

G-Protein Coupled Receptors, Inflammation
  1. Discovery of therapeutic targets in multiple sclerosis (MS) and related neurological disorders.
  2. Systems biology approaches to the study of lipid mediators and G protein-coupled receptors (GPCRs).

Yasuyuki Kihara's Bio

Education

Ph.D., University of Tokyo (JAPAN), Biochemistry and Molecular Biology
M.S., University of Tokyo (JAPAN), Medical Science
B.Pharm., Meiji Pharmaceutical University (JAPAN), Pharmacy

 

Honors and Recognition

2011-2014: HFSP Long-Term Fellowship
2009: Japanese Society of Neuroimmunology Award


pipetting

Publications

Computational Modeling of Competitive Metabolism between ω3- and ω6-Polyunsaturated Fatty Acids in Inflammatory Macrophages.

Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S

J Phys Chem B 2016 Aug 25 ;120(33):8346-53

Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models.

Kihara Y, Groves A, Rivera RR, Chun J

Ann Clin Transl Neurol 2015 Oct ;2(10):978-83

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.

Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA

Cell 2015 Jun 18 ;161(7):1633-43

Show All Select Publications

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Abbracchio MP, Abraham G, Agoulnik A, Alexander W, Al-Hosaini K, Bäck M, Baker JG, Barnes NM, Bathgate R, Beaulieu JM, Beck-Sickinger AG, Behrens M, Bernstein KE, Bettler B, Birdsall NJM, Blaho V, Boulay F, Bousquet C, Bräuner-Osborne H, Burnstock G, Caló G, Castaño JP, Catt KJ, Ceruti S, Chazot P, Chiang N, Chini B, Chun J, Cianciulli A, Civelli O, Clapp LH, Couture R, Cox HM, Csaba Z, Dahlgren C, Dent G, Douglas SD, Dournaud P, Eguchi S, Escher E, Filardo EJ, Fong T, Fumagalli M, Gainetdinov RR, Garelja ML, de Gasparo M, Gerard C, Gershengorn M, Gobeil F, Goodfriend TL, Goudet C, Grätz L, Gregory KJ, Gundlach AL, Hamann J, Hanson J, Hauger RL, Hay DL, Heinemann A, Herr D, Hollenberg MD, Holliday ND, Horiuchi M, Hoyer D, Hunyady L, Husain A, IJzerman AP, Inagami T, Jacobson KA, Jensen RT, Jockers R, Jonnalagadda D, Karnik S, Kaupmann K, Kemp J, Kennedy C, Kihara Y, Kitazawa T, Kozielewicz P, Kreienkamp HJ, Kukkonen JP, Langenhan T, Larhammar D, Leach K, Lecca D, Lee JD, Leeman SE, Leprince J, Li XX, Lolait SJ, Lupp A, Macrae R, Maguire J, Malfacini D, Mazella J, McArdle CA, Melmed S, Michel MC, Miller LJ, Mitolo V, Mouillac B, Müller CE, Murphy PM, Nahon JL, Ngo T, Norel X, Nyimanu D, O'Carroll AM, Offermanns S, Panaro MA, Parmentier M, Pertwee RG, Pin JP, Prossnitz ER, Quinn M, Ramachandran R, Ray M, Reinscheid RK, Rondard P, Rovati GE, Ruzza C, Sanger GJ, Schöneberg T, Schulte G, Schulz S, Segaloff DL, Serhan CN, Singh KD, Smith CM, Stoddart LA, Sugimoto Y, Summers R, Tan VP, Thal D, Thomas WW, Timmermans PBMWM, Tirupula K, Toll L, Tulipano G, Unal H, Unger T, Valant C, Vanderheyden P, Vaudry D, Vaudry H, Vilardaga JP, Walker CS, Wang JM, Ward DT, Wester HJ, Willars GB, Williams TL, Woodruff TM, Yao C, Ye RD

Br J Pharmacol 2023 Oct ;180 Suppl 2:S23-S144

FTY720 requires vitamin B(12)-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis.

Jonnalagadda D, Kihara Y, Groves A, Ray M, Saha A, Ellington C, Lee-Okada HC, Furihata T, Yokomizo T, Quadros EV, Rivera R, Chun J

Cell Rep 2023 Dec 26 ;42(12):113545

CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries.

Abi-Ghanem C, Jonnalagadda D, Chun J, Kihara Y, Ranscht B

Front Cell Neurosci 2022 ;16:908401

Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA(2)), UCM-14216, Ameliorates Spinal Cord Injury in Mice.

Khiar-Fernández N, Zian D, Vázquez-Villa H, Martínez RF, Escobar-Peña A, Foronda-Sainz R, Ray M, Puigdomenech-Poch M, Cincilla G, Sánchez-Martínez M, Kihara Y, Chun J, López-Vales R, López-Rodríguez ML, Ortega-Gutiérrez S

J Med Chem 2022 Aug 25 ;65(16):10956-10974

Single-Nucleus RNA-seq of Normal-Appearing Brain Regions in Relapsing-Remitting vs. Secondary Progressive Multiple Sclerosis: Implications for the Efficacy of Fingolimod.

Kihara Y, Zhu Y, Jonnalagadda D, Romanow W, Palmer C, Siddoway B, Rivera R, Dutta R, Trapp BD, Chun J

Front Cell Neurosci 2022 ;16:918041

Show All Publications