Pamela Itkin-Ansari earned her PhD in Biomedical Sciences from the University of California, San Diego, in 1999. She received postdoctoral training focused on diabetes at that same organization. In 2003, Dr. Itkin-Ansari was appointed Assistant Professor in the Department of Pediatrics, UC San Diego. She moved her laboratory to Sanford Burnham Prebys in 2005.
Funding Awards and Collaborative Grants
California Institute for Regenerative Medicine (CIRM)
Falk Foundation
The Hartwell Foundation
The Hirshberg Foundation
Juvenile Diabetes Research Foundation (JDRF)
National Institutes of Health
Select Honors and Recognition
2013-2014: Outstanding Faculty Mentor Award, UCSD
2011-2014: Hartwell Foundation Biomedical Research Award
2011: Invited Speaker, TEDx
2008-2013: Board of Directors, JDRF San Diego
2008: Health Hero Leadership Award, Combined Health Agencies of San Diego
Other Affiliations
2012-current: Islet Society
2010-current: ASGCT
2008-current: Board of Directors, JDRF San Diego chapter
2008-2013: JDRF board of directors, San Diego
2007-current: American Association for Cancer Research
2007-current: American Diabetes Association
2007-current: American Pediatric Society/Society for Pediatric Research
2006-current: AAAS
Related Disease
Cancer, Diabetes – General, Gastric Cancer, Monogenic Diabetes, Pancreatic Cancer, Type 1 Diabetes, Type 2 Diabetes
Dr. Itkin-Ansari’s research is directed toward understanding diseases of the human pancreas.
Pamela Itkin-Ansari’s Research Report
Diabetes
Areas of focus are: 1) developing a cell-based therapy for diabetes that does not require immunosuppression, and 2) identifying proteins required for proper insulin production and processing.

Islet clusters in the developing pancreas
Pancreatic Cancer
The lab determined how dysregulation of specific transcription factors triggers pathogenic cell cycle entry in normal pancreatic cells. This master signaling pathway controlling pancreatic cancer cell growth is yielding potential targets for drug discovery.

Id3 (green) in human pancreatic cancer
- May 27, 2025
Scientists and podcasters
May 27, 2025Sanford Burnham Prebys scientists bring dramatic stories of scientific achievement to life.
- May 22, 2024
Pancreatic cancer symposium celebrates 10th anniversary in San Diego
May 22, 2024The 2024 PancWest Symposium brought more than 120 scientists to the Sanford Burnham Prebys campus in San Diego to discuss…
- Mar 28, 2023
Behind the scenes at Sanford Burnham Prebys’ Cancer Center
Mar 28, 2023Cancer Center open house connects San Diego community with scientists working toward cancer cures
- Oct 26, 2022
Research unlocks the circuitry of diabetes
Oct 26, 2022Research led by Pamela-Itkin-Ansari, PhD, and Randal Kaufman PhD, has mapped out a network of biochemical interactions that help special…
- May 27, 2020
First map of proinsulin’s “social network” reveals new drug target for type 2 diabetes
May 27, 2020Study reveals previously unknown protein that helps proinsulin fold and opens new avenues for diabetes research Scientists at Sanford Burnham…
- Jan 29, 2016
SBP supports opening of stem cell exhibit at the Reuben H. Fleet Science Center
Jan 29, 2016Pamela Itkin-Ansari, PhD, adjunct assistant professor in the Development, Aging, and Regeneration Program at SBP, participated in the grand opening…
Select Publications
Showing 3 of 3Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.
Tran DT, Pottekat A, Lee K, Raghunathan M, Loguercio S, Mir SA, Paton AW, Paton JC, Arvan P, Kaufman RJ, Itkin-Ansari P
J Clin Endocrinol Metab 2022 Nov 23 ;107(11):3100-3110Expression Profiles of ID and E2A in Ovarian Cancer and Suppression of Ovarian Cancer by the E2A Isoform E47.
Lee YJ, Nam EJ, Kim S, Kim YT, Itkin-Ansari P, Kim SW
Cancers (Basel) 2022 Jun 12 ;14(12):Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.
Liu M, Huang Y, Xu X, Li X, Alam M, Arunagiri A, Haataja L, Ding L, Wang S, Itkin-Ansari P, Kaufman RJ, Tsai B, Qi L, Arvan P
J Clin Invest 2021 Jan 19 ;131(2):