Almost 6 million people in the US have failing hearts, which can arise following heart attacks, longstanding high blood pressure, defective heart valves or genetic disorders, among other causes. While management of heart failure (HF) is improving, only 50% of patients will survive five years after diagnosis. No current treatments directly treat the disease, particularly at early stages, so development of new preventive or therapeutic drugs could make an enormous difference for patients.  Continue reading “How energy starvation leads to heart failure”