Cardiovascular Pathobiology Program Archives - Sanford Burnham Prebys
Institute News

A signature for early-stage heart failure could improve diagnosis and prevent disease progression

AuthorGuest Blogger
Date

September 30, 2014

This is a post by our guest writer Janelle Weaver, PhD

Heart failure affects about five million people in the United States, and about half of these individuals die within five years of diagnosis. This condition occurs when the heart can’t pump enough blood to meet the body’s needs, and evidence suggests that abnormalities in energy metabolism play an important role. However, many past studies addressing the underlying molecular mechanisms have focused on severe, late-stage heart failure, potentially missing out on early events that could guide the development of treatment strategies for early disease stages. Continue reading “A signature for early-stage heart failure could improve diagnosis and prevent disease progression”

Institute News

Genes promote hardening of arteries in type 2 diabetes

Authorsgammon
Date

July 15, 2014

Type 2 diabetes has become a national epidemic, affecting nearly 26 million children and adults in the U.S. and approximately 170 million worldwide. According to the American Diabetes Association, $245 billion in costs are associated with diabetes, and 1 in 5 health-care dollars is spent caring for diabetics. A significant portion of the health costs associated with diabetes are those attributed to complications of the disease—including heart attacks, heart failure, stroke, dementia, chronic kidney disease, and amputations of the lower limbs. These complications emerge partly from hardening of the arteries caused by calcium deposits—a process known as arterial calcification—and are much more common in type 2 diabetics than in non-diabetics. Continue reading “Genes promote hardening of arteries in type 2 diabetes”