Cell Reports Archives - Sanford Burnham Prebys

Tag: Cell Reports

Institute News

Pathway that controls cancer cell proliferation discovered

Authorsgammon
Date

August 13, 2015

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In a new study by SBP, researchers have identified a novel kinase cascade that regulates mTORC1, a protein complex implicated in the control of cancer cell growth in response to nutrients. The study, published in Cell Reports, provides further insight into the control of mTORC1 activation, and highlights several new potential drug targets to treat human pathologies linked to mTORC1 deregulation. Continue reading “Pathway that controls cancer cell proliferation discovered”

Institute News

Sanford-Burnham researchers identify a new target for treating drug-resistant melanoma

Authorsgammon
Date

May 28, 2015

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A new collaborative study led by researchers at Sanford-Burnham, published today in Cell Reports, provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs called BRAF inhibitors. The findings suggest that targeting newly discovered pathways could be an effective approach to improving the clinical outcome of patients with BRAF inhibitor-resistant melanoma tumors. Continue reading “Sanford-Burnham researchers identify a new target for treating drug-resistant melanoma”

Institute News

New study sheds light on cancer stem cell regulation

Authorsgammon
Date

February 5, 2015

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Researchers at Sanford-Burnham have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers. The results of the study appear online in Cell Reports today. Continue reading “New study sheds light on cancer stem cell regulation”

Institute News

The bright side of free radicals

Authorsgammon
Date

September 17, 2014

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In a new study by Rolf Bodmer, Ph.D., director of the Development, Aging, and Regeneration Program at Sanford-Burnham, and Hui-Ying Lim, Ph.D., assistant member of the Free Radical Biology and Aging Program at the Oklahoma Medical Research Foundation as lead author, researchers report a previously unrecognized role for reactive oxygen species (ROS) in mediating normal heart function. The findings show how under normal physiological conditions, ROS produced in non-muscle heart cells act on nearby muscle cells to maintain normal cardiac function. The results provide vital insight on how ROS direct cell communications, and in addition to the heart, may be important for the function of other organs. Continue reading “The bright side of free radicals”