The newly discovered role of a vascular protein in diabetes-induced hardening of the arteries could lead to better treatments that reduce the risk of heart attack, stroke, and death, according to research spearheaded by SBP investigators. The study, published recently in Circulation Research, reveals that a receptor called LRP6 inhibits molecular signals that drive diet-induced hardening of the arteries, also known as arteriosclerosis. Continue reading “Potential drug targets could improve treatment of vascular disease in diabetic patients”
Tag: Dwight Towler
Sanford-Burnham welcomes two new scientists to Lake Nona
We’re excited to announce that we have recruited two cardiometabolic experts to our Medical City campus in Lake Nona (Orlando), Fla. Peter A. Crawford, MD, PhD, and Andre d’Avignon, PhD, join our Cardiovascular Pathobiology Program from Washington University in St. Louis, Mo. The increasing density of local scientists and clinicians in Orlando is accelerating the growth of the region’s bio-medical industry, promoting both economic development and the quality of health care. Continue reading “Sanford-Burnham welcomes two new scientists to Lake Nona”
Genes promote hardening of arteries in type 2 diabetes
Type 2 diabetes has become a national epidemic, affecting nearly 26 million children and adults in the U.S. and approximately 170 million worldwide. According to the American Diabetes Association, $245 billion in costs are associated with diabetes, and 1 in 5 health-care dollars is spent caring for diabetics. A significant portion of the health costs associated with diabetes are those attributed to complications of the disease—including heart attacks, heart failure, stroke, dementia, chronic kidney disease, and amputations of the lower limbs. These complications emerge partly from hardening of the arteries caused by calcium deposits—a process known as arterial calcification—and are much more common in type 2 diabetics than in non-diabetics. Continue reading “Genes promote hardening of arteries in type 2 diabetes”