Generally, T cells, the policemen of the body, activate immune responses upon finding infected or diseased cells, but some T cells respond the same way to normal cells in the body. If unchecked, such T cells can cause autoimmune diseases such as psoriasis, rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis. These self-reactive T cells are a recently discovered type of T cell, the TH17 cell. Preventing young T cells from becoming TH17 cells is of major interest as a means to treat autoimmune diseases. Continue reading “New insight on the development of T cells that promote autoimmune disease”
Tag: Fraydoon Rastinejad
New STRIVE awards announced
“The STRIVE award is providing funds that allow us to accelerate the testing of a new hypothesis that connects the microbiome, epigenetics, and colorectal cancer.”
–Alex Strongin, PhD professor in the Bioinformatics and Structural Biology Program at SBP. Continue reading “New STRIVE awards announced”
Scientists solve structure of important protein for tumor growth
In a collaborative study between SBP and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors (HIFs), important regulators of a tumor’s response to low oxygen (hyopoxia). The findings, published today in the journal Nature, open the door to search for new drugs to treat tumors by cutting off their supply of oxygen and nutrients. Continue reading “Scientists solve structure of important protein for tumor growth”