Meet one of our early-career scientists at Sanford Burnham Prebys: Arailym Sarsembayeva, PhD, a postdoctoral researcher in the lab of Eric Wang, PhD.
What lab are you in, and what research are you working on?
I’m currently working in Eric Wang’s lab, which specializes in chemical biology and the development of targeted protein degradation therapeutics against traditionally “undruggable” transcription factors. My project focuses on Helios, a transcription factor highly expressed in regulatory T cells and exhausted CD8+ T cells. I am investigating the effects of Helios degradation on T cell function and exhaustion phenotypes, with the aim of elucidating the underlying mechanisms that modulate tumor immune evasion. Ultimately, this work will not only clarify the role of Helios in T cells but may also guide the optimal deployment of Helios degraders in clinical settings.
When did you know you wanted to be a scientist?
I grew up around medicine—my mother is a general practitioner—and was always curious about diseases and how the body works. That early exposure sparked my interest in biomedical science, which I pursued with a presidential scholarship at Dublin Technological University. During my studies, I became increasingly fascinated by immunology and the vital role the immune system plays in health and disease. This passion led me to Kazakhstan for a master’s program and then to Austria for my PhD, where I focused on cancer immunology. Specifically, I explored how cannabinoid receptors on immune cells interact with tumors, which opened my eyes to the complex ways our body fights cancer. It’s been an incredible journey, blending my love for medicine and science.
How did you find your way to Sanford Burnham Prebys?
I discovered Eric Wang’s lab through LinkedIn. When I researched Sanford Burnham Prebys and saw the motto, ‘We translate science into health,’ I immediately felt it was the right place for me. The institute is the perfect size—not too big, not too small—and is situated in a highly collaborative environment in San Diego, which aligns perfectly with my goals and working style.
What do you like about working at the Institute?
I love the collaborative and supportive atmosphere. My colleagues and collaborators are amazing, and the Office of Education, Training & International Services (OETIS) provides postdocs with great resources—from leadership seminars and writing workshops to grant training. The scientific environment here is excellent, with top-tier core facilities and seminars featuring scientists from across the U.S., which keeps me inspired and engaged.
What’s been a challenge in your postdoc journey?
Since this is my first postdoctoral position, one of the biggest challenges has been transitioning from being a PhD student to an independent researcher. Initially, I wasn’t sure how to act or how much independence was expected. However, I’m learning as I go, and I’ve had great mentorship from Eric Wang and others. It’s a continuous process of gaining confidence and skills.
Congratulations on your fellowship! Can you tell us more about it?
Thank you! I was recently awarded a three-year postdoctoral fellowship from the American Cancer Society. It’s fully funded, which is a huge relief and allows me to focus deeply on my research. I’m especially excited about the professional development support and opportunities for collaboration that come with the fellowship. It’s a great step forward as I continue to grow as an independent cancer researcher.
For almost 80 years, the American Cancer Society has been at the forefront of funding groundbreaking research that has transformed cancer prevention, detection, and treatment. I am extremely proud to be part of an organization with such a rich legacy, committed to supporting the best science to benefit cancer patients and their families for generations to come.
What are your goals for the next stage of your career?
My goals for the next stage of my career are to deepen my research expertise while expanding my leadership and mentorship experience. I’m considering a transition into industry, particularly roles that allow me to work at the intersection of applied research and innovation. However, I still have a strong interest in leading my own research team in the future. This postdoctoral position offers an ideal opportunity to develop leadership skills through project management and interdisciplinary collaboration, while continuing to publish and refine my scientific contributions.
Have you had a mentor who made a big impact on you?
Yes, especially my master’s advisor, Dr. Eva Reithmacher. She’s a strong woman in science who supported and encouraged me every step of the way. Her mentorship had a big influence on my path.
What do you enjoy outside the lab?
Outside the lab, I really enjoy hiking, baking, horseback riding, and just walking along the beach. Being outdoors is really important to me and living in San Diego makes it easy to get outside and enjoy nature every day!
What advice would you give to aspiring scientists?
Pursue your dreams and don’t give up. Science is full of ups and downs, but if you’re passionate and curious about discovering new things, it’s worth it. Be resilient and keep going.
Postdocs at Sanford Burnham Prebys are pushing the boundaries of science every day through curiosity, collaboration, and innovation. This series highlights their unique journeys, what inspires their work, and the impact they’re making across our labs.