Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
- Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases. -
An evening with autoimmune disorder experts
Three experts—a scientist, a doctor and a patient—shared their perspective on a single topic: autoimmune disorders. -
5 lessons I’ve learned from rheumatoid arthritis and why I’m grateful to scientists who can change my world
Angela Durazo was a rising star triathlete. Then a diagnosis with a autoimmune disorder turned her life upside down. -
Immune therapy enters Phase 1 clinical trial
Sanford Burnham Prebys Medical Discovery Institute (SBP) today announced that the first healthy subject has been dose
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How can prebiotics help your gut health?
Scott Peterson Ph.D., professor SBP, recently worked with researchers to assess the effects of prebiotics on gut health. -
Cancer immunology symposium highlights hot area in cancer research
The Cancer Immunology and Tumor Microenvironment Symposium held at Sanford Burnham Prebys Medical Discovery Institute
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Viral tricks inspire autoimmune drug design
In the U.S.
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How RNA splicing can trigger cancer
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of
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New grant supports Ebola drug discovery
Ebola’s reputation as a killer virus is well deserved—the most recent outbreak, in West Africa from 2014-2016, caused
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Research to combat biothreat of “Black Death”
The plague, also known as the Black Death, wiped out a third of Europe’s population in the 14th century an
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SBP President’s Lecture highlights new approach to cancer immunotherapy
One of the most promising new approaches to treating cancer is immunotherapy—redirecting the immune system to detect
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
Beneficial and Adverse Effects of cART Affect Neurocognitive Function in HIV-1 Infection: Balancing Viral Suppression against Neuronal Stress and Injury.
Yuan NY, Kaul M
J Neuroimmune Pharmacol 2019 Aug 6 ;
B-Vitamin Sharing Promotes Stability of Gut Microbial Communities.
Sharma V, Rodionov DA, Leyn SA, Tran D, Iablokov SN, Ding H, Peterson DA, Osterman AL, Peterson SN
Front Microbiol 2019 ;10:1485
A sparse covarying unit that describes healthy and impaired human gut microbiota development.
Raman AS, Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Subramanian S, Kang G, Bessong PO, Lima AAM, Kosek MN, Petri WA Jr, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Huq S, Mostafa I, Islam M, Mahfuz M, Haque R, Ahmed T, Barratt MJ, Gordon JI
Science 2019 Jul 12 ;365(6449)
Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, Giannone RJ, Hettich RL, Ilkayeva O, Muehlbauer M, Newgard CB, Sawyer C, Head RD, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Hossain MI, Islam M, Choudhury N, Sarker SA, Huq S, Mahmud I, Mostafa I, Mahfuz M, Barratt MJ, Ahmed T, Gordon JI
Science 2019 Jul 12 ;365(6449)
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523