Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
– Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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COVID-19: Renowned scientist enters clinical trial
After a career of exploring how viruses wreak havoc on our health, researcher now becomes a “subject” in a vaccine study. -
A scientist’s perspective on the coronavirus (COVID-19) pandemic
Infectious disease expert Sumit Chanda tells us how his team is combating the virus, and the advice he gives his loved ones. -
Scientists discover an early sign of type 2 diabetes: Misfolded proinsulin
The findings could lead to tests or treatments that help prevent type 2 diabetes. -
Should you be worried about the never-before-seen coronavirus outbreak?
Here’s what Sumit Chanda, Ph.D., director of Sanford Burnham Prebys’ Immunity and Pathogenesis Program, has to say about the virus spreading fear around the world. -
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases. -
5 lessons I’ve learned from rheumatoid arthritis and why I’m grateful to scientists who can change my world
Angela Durazo was a rising star triathlete. Then a diagnosis with a autoimmune disorder turned her life upside down. -
An evening with autoimmune disorder experts
Three experts—a scientist, a doctor and a patient—shared their perspective on a single topic: autoimmune disorders. -
Immune therapy enters Phase 1 clinical trial
Sanford Burnham Prebys Medical Discovery Institute (SBP) today announced that the first healthy subject has been dose
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How can prebiotics help your gut health?
Scott Peterson Ph.D., professor SBP, recently worked with researchers to assess the effects of prebiotics on gut health. -
Cancer immunology symposium highlights hot area in cancer research
The Cancer Immunology and Tumor Microenvironment Symposium held at Sanford Burnham Prebys Medical Discovery Institute
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Viral tricks inspire autoimmune drug design
In the U.S.
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV
Nat Chem Biol 2020 Jun 29 ;
Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation.
Li X, Zhao J, Kasinath V, Uehara M, Jiang L, Banouni N, McGrath MM, Ichimura T, Fiorina P, Lemos DR, Shin SR, Ware CF, Bromberg JS, Abdi R
J Clin Invest 2020 Jun 29 ;
IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.
Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H
Gastroenterology 2020 Jun 20 ;
Lipocalin-2 mediates HIV-1 induced neuronal injury and behavioral deficits by overriding CCR5-dependent protection.
Ojeda-Juárez D, Shah R, Fields JA, Harahap-Carrillo IS, Koury J, Maung R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M
Brain Behav Immun 2020 Jun 11 ;
Complete and Draft Genome Sequences of 12 Plant-Associated <i>Rathayibacter</i> Strains of Known and Putative New Species.
Tarlachkov SV, Starodumova IP, Dorofeeva LV, Prisyazhnaya NV, Leyn SA, Zlamal JE, Elane ML, Osterman AL, Nadler SA, Subbotin SA, Evtushenko LI
Microbiol Resour Announc 2020 May 28 ;9(22)
Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.
Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ
Nat Neurosci 2020 Jul ;23(7):842-853