Infectious and Inflammatory Diseases Center

Center for Stem Cells and Regenerative Medicine

Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.

“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”

Carl Ware, Ph.D., Center Director

 

Understanding the fundamentals of inflammation and immunity

Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.

Program

Immunity and Pathogenesis Program

By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.

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Latest news

Publications

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS

Nat Med 2019 May ;25(5):805-813

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.

Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L

ACS Chem Biol 2019 May 17 ;14(5):949-958

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK

Nat Commun 2019 Apr 3 ;10(1):1523

Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR.

Arzamasov AA, Nakajima A, Sakanaka M, Ojima MN, Katayama T, Rodionov DA, Osterman AL

mSystems 2022 Sep 12 ;:e0034322

Establishment of blood glycosidase activities and their excursions in sepsis.

Haslund-Gourley BS, Aziz PV, Heithoff DM, Restagno D, Fried JC, Ilse MB, Bäumges H, Mahan MJ, Lübke T, Marth JD

PNAS Nexus 2022 Jul ;1(3):pgac113

Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia.

Sorrentino JT, Golden GJ, Morris C, Painter CD, Nizet V, Campos AR, Smith JW, Karlsson C, Malmström J, Lewis NE, Esko JD, Gómez Toledo A

mSystems 2022 Aug 30 ;7(4):e0039522

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.

Pohl MO, Martin-Sancho L, Ratnayake R, White KM, Riva L, Chen QY, Lieber G, Busnadiego I, Yin X, Lin S, Pu Y, Pache L, Rosales R, Déjosez M, Qin Y, De Jesus PD, Beall A, Yoh S, Hale BG, Zwaka TP, Matsunaga N, García-Sastre A, Stertz S, Chanda SK, Luesch H

ACS Infect Dis 2022 Jul 8 ;8(7):1265-1279

Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans.

Han ND, Cheng J, Delannoy-Bruno O, Webber D, Terrapon N, Henrissat B, Rodionov DA, Arzamasov AA, Osterman AL, Hayashi DK, Meynier A, Vinoy S, Desai C, Marion S, Barratt MJ, Heath AC, Gordon JI

Cell 2022 Jul 7 ;185(14):2495-2509.e11

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