Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
– Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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Three big questions for cutting-edge biologist Will Wang
Will Wang’s works at the intersection of biology and computer science to study how complex systems of cells interact and how these systems contribute to neuromuscular disease -
Yasuyuki Kihara wins a dream award
Research Assistant Professor Yasuyuki Kihara, Ph.D., has won an Eicosanoid Research Foundation (ERF) Young Investigator Award, an award for researchers working in lipid biology. -
How our immune system controls gut microbes
Researchers from Sanford Burnham Prebys have revealed a new function for a previously-known immune molecule, a discovery with implications for the treatment of autoimmune and gastrointestinal diseases. -
A strange research ecosystem: Discussing Lyme disease with Victoria Blaho
We caught up with Sanford Burnham Prebys assistant professor Victoria Blaho, Ph.D. to talk about why Lyme disease research is important, the progress being made and the work that remains in studying this strange and burdensome disease. -
Laura Martin-Sancho rises to the challenge of COVID-19
The journal Molecular Cell recently asked Laura Martin-Sancho to share her experience working on SARS-CoV-2 during the pandemic. -
COVID-19 vaccines: Our experts weigh in on the historic news
Our leading COVID-19 researchers give their take on the Pfizer vaccine -
COVID-19: Renowned scientist enters clinical trial
After a career of exploring how viruses wreak havoc on our health, researcher now becomes a “subject” in a vaccine study. -
Scientists discover an early sign of type 2 diabetes: Misfolded proinsulin
The findings could lead to tests or treatments that help prevent type 2 diabetes. -
A scientist’s perspective on the coronavirus (COVID-19) pandemic
Infectious disease expert Sumit Chanda tells us how his team is combating the virus, and the advice he gives his loved ones. -
Should you be worried about the never-before-seen coronavirus outbreak?
Here’s what Sumit Chanda, Ph.D., director of Sanford Burnham Prebys’ Immunity and Pathogenesis Program, has to say about the virus spreading fear around the world. -
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases.
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.
Shrestha J, Santerre M, Allen CN, Arjona SP, Hooper R, Mukerjee R, Kaul M, Shcherbik N, Soboloff J, Sawaya BE
Mitochondrion 2023 Mar 15 ;70:31-40
Milk glycan metabolism by intestinal bifidobacteria: insights from comparative genomics.
Arzamasov AA, Osterman AL
Crit Rev Biochem Mol Biol 2023 Mar 3 ;:1-23
Addressing barriers in FAIR data practices for biomedical data.
Hughes LD, Tsueng G, DiGiovanna J, Horvath TD, Rasmussen LV, Savidge TC, Stoeger T, Turkarslan S, Wu Q, Wu C, Su AI, Pache L, NIAID Systems Biology Data Dissemination Working Group
Sci Data 2023 Feb 23 ;10(1):98
Developing a standardized but extendable framework to increase the findability of infectious disease datasets.
Tsueng G, Cano MAA, Bento J, Czech C, Kang M, Pache L, Rasmussen LV, Savidge TC, Starren J, Wu Q, Xin J, Yeaman MR, Zhou X, Su AI, Wu C, Brown L, Shabman RS, Hughes LD, NIAID Systems Biology Data Dissemination Working Group
Sci Data 2023 Feb 23 ;10(1):99
Identification of global inhibitors of cellular glycosylation.
Sørensen DM, Büll C, Madsen TD, Lira-Navarrete E, Clausen TM, Clark AE, Garretson AF, Karlsson R, Pijnenborg JFA, Yin X, Miller RL, Chanda SK, Boltje TJ, Schjoldager KT, Vakhrushev SY, Halim A, Esko JD, Carlin AF, Hurtado-Guerrero R, Weigert R, Clausen H, Narimatsu Y
Nat Commun 2023 Feb 20 ;14(1):948
Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2.
Kallol S, Martin-Sancho L, Morey R, Aisagbonhi O, Pizzo D, Meads M, Chanda SK, Soncin F
Stem Cells Dev 2023 Mar 22 ;
