Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
– Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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How our immune system controls gut microbes
Researchers from Sanford Burnham Prebys have revealed a new function for a previously-known immune molecule, a discovery with implications for the treatment of autoimmune and gastrointestinal diseases. -
A strange research ecosystem: Discussing Lyme disease with Victoria Blaho
We caught up with Sanford Burnham Prebys assistant professor Victoria Blaho, Ph.D. to talk about why Lyme disease research is important, the progress being made and the work that remains in studying this strange and burdensome disease. -
Laura Martin-Sancho rises to the challenge of COVID-19
The journal Molecular Cell recently asked Laura Martin-Sancho to share her experience working on SARS-CoV-2 during the pandemic. -
COVID-19 vaccines: Our experts weigh in on the historic news
Our leading COVID-19 researchers give their take on the Pfizer vaccine -
COVID-19: Renowned scientist enters clinical trial
After a career of exploring how viruses wreak havoc on our health, researcher now becomes a “subject” in a vaccine study. -
Scientists discover an early sign of type 2 diabetes: Misfolded proinsulin
The findings could lead to tests or treatments that help prevent type 2 diabetes. -
A scientist’s perspective on the coronavirus (COVID-19) pandemic
Infectious disease expert Sumit Chanda tells us how his team is combating the virus, and the advice he gives his loved ones. -
Should you be worried about the never-before-seen coronavirus outbreak?
Here’s what Sumit Chanda, Ph.D., director of Sanford Burnham Prebys’ Immunity and Pathogenesis Program, has to say about the virus spreading fear around the world. -
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases. -
An evening with autoimmune disorder experts
Three experts—a scientist, a doctor and a patient—shared their perspective on a single topic: autoimmune disorders. -
5 lessons I’ve learned from rheumatoid arthritis and why I’m grateful to scientists who can change my world
Angela Durazo was a rising star triathlete. Then a diagnosis with a autoimmune disorder turned her life upside down.
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR.
Arzamasov AA, Nakajima A, Sakanaka M, Ojima MN, Katayama T, Rodionov DA, Osterman AL
mSystems 2022 Sep 12 ;:e0034322
Establishment of blood glycosidase activities and their excursions in sepsis.
Haslund-Gourley BS, Aziz PV, Heithoff DM, Restagno D, Fried JC, Ilse MB, Bäumges H, Mahan MJ, Lübke T, Marth JD
PNAS Nexus 2022 Jul ;1(3):pgac113
Vascular Proteome Responses Precede Organ Dysfunction in a Murine Model of Staphylococcus aureus Bacteremia.
Sorrentino JT, Golden GJ, Morris C, Painter CD, Nizet V, Campos AR, Smith JW, Karlsson C, Malmström J, Lewis NE, Esko JD, Gómez Toledo A
mSystems 2022 Aug 30 ;7(4):e0039522
Arachidonic Acid Cascade and Eicosanoid Production Are Elevated While LTC4 Synthase Modulates the Lipidomics Profile in the Brain of the HIVgp120-Transgenic Mouse Model of NeuroHIV.
Yuan NY, Maung R, Xu Z, Han X, Kaul M
Cells 2022 Jul 5 ;11(13)
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.
Pohl MO, Martin-Sancho L, Ratnayake R, White KM, Riva L, Chen QY, Lieber G, Busnadiego I, Yin X, Lin S, Pu Y, Pache L, Rosales R, Déjosez M, Qin Y, De Jesus PD, Beall A, Yoh S, Hale BG, Zwaka TP, Matsunaga N, García-Sastre A, Stertz S, Chanda SK, Luesch H
ACS Infect Dis 2022 Jul 8 ;8(7):1265-1279
Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans.
Han ND, Cheng J, Delannoy-Bruno O, Webber D, Terrapon N, Henrissat B, Rodionov DA, Arzamasov AA, Osterman AL, Hayashi DK, Meynier A, Vinoy S, Desai C, Marion S, Barratt MJ, Heath AC, Gordon JI
Cell 2022 Jul 7 ;185(14):2495-2509.e11