Infectious and Inflammatory Diseases Center

Center for Stem Cells and Regenerative Medicine

Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.

“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”

Carl Ware, Ph.D., Center Director

 

Understanding the fundamentals of inflammation and immunity

Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.

Program

Immunity and Pathogenesis Program

By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.

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Latest news

Publications

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS

Nat Med 2019 May ;25(5):805-813

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.

Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L

ACS Chem Biol 2019 May 17 ;14(5):949-958

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK

Nat Commun 2019 Apr 3 ;10(1):1523

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.

Immler R, Nussbaumer K, Doerner A, El Bounkari O, Huber S, Abisch J, Napoli M, Schmidt S, Margraf A, Pruenster M, Rohwedder I, Lange-Sperandio B, Mall MA, de Jong R, Ohnmacht C, Bernhagen J, Voehringer D, Marth JD, Frommhold D, Sperandio M

Proc Natl Acad Sci U S A 2024 May 7 ;121(19):e2319057121

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition.

Chang HW, Lee EM, Wang Y, Zhou C, Pruss KM, Henrissat S, Chen RY, Kao C, Hibberd MC, Lynn HM, Webber DM, Crane M, Cheng J, Rodionov DA, Arzamasov AA, Castillo JJ, Couture G, Chen Y, Balcazo NP Jr, Lebrilla CB, Terrapon N, Henrissat B, Ilkayeva O, Muehlbauer MJ, Newgard CB, Mostafa I, Das S, Mahfuz M, Osterman AL, Barratt MJ, Ahmed T, Gordon JI

Nat Microbiol 2024 Apr ;9(4):922-937

Sporadic Inclusion Body Myositis at the Crossroads between Muscle Degeneration, Inflammation, and Aging.

Guglielmi V, Cheli M, Tonin P, Vattemi G

Int J Mol Sci 2024 Feb 27 ;25(5)

A critical role for Macrophage-derived Cysteinyl-Leukotrienes in HIV-1 induced neuronal injury.

Yuan NY, Medders KE, Sanchez AB, Shah R, de Rozieres CM, Ojeda-Juárez D, Maung R, Williams R, Gelman BB, Baaten BJ, Roberts AJ, Kaul M

Brain Behav Immun 2024 May ;118:149-166

Interferon-β deficiency alters brain response to chronic HIV-1 envelope protein exposure in a transgenic model of NeuroHIV.

Singh H, Koury J, Maung R, Roberts AJ, Kaul M

Brain Behav Immun 2024 May ;118:1-21

A novel antibiotic class targeting the lipopolysaccharide transporter.

Zampaloni C, Mattei P, Bleicher K, Winther L, Thäte C, Bucher C, Adam JM, Alanine A, Amrein KE, Baidin V, Bieniossek C, Bissantz C, Boess F, Cantrill C, Clairfeuille T, Dey F, Di Giorgio P, du Castel P, Dylus D, Dzygiel P, Felici A, García-Alcalde F, Haldimann A, Leipner M, Leyn S, Louvel S, Misson P, Osterman A, Pahil K, Rigo S, Schäublin A, Scharf S, Schmitz P, Stoll T, Trauner A, Zoffmann S, Kahne D, Young JAT, Lobritz MA, Bradley KA

Nature 2024 Jan ;625(7995):566-571

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