Infectious and Inflammatory Diseases Center

Center for Stem Cells and Regenerative Medicine

Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.

“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”

Carl Ware, Ph.D., Center Director

 

Understanding the fundamentals of inflammation and immunity

Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.

Program

Immunity and Pathogenesis Program

By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.

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Latest news

Publications

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS

Nat Med 2019 May ;25(5):805-813

Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.

Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L

ACS Chem Biol 2019 May 17 ;14(5):949-958

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.

Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK

Nat Commun 2019 Apr 3 ;10(1):1523

Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets.

Cheng K, Martin-Sancho L, Pal LR, Pu Y, Riva L, Yin X, Sinha S, Nair NU, Chanda SK, Ruppin E

Mol Syst Biol 2021 Nov ;17(11):e10260

Global Expansion of Linezolid-Resistant Coagulase-Negative Staphylococci.

Gostev V, Leyn S, Kruglov A, Likholetova D, Kalinogorskaya O, Baykina M, Dmitrieva N, Grigorievskaya Z, Priputnevich T, Lyubasovskaya L, Gordeev A, Sidorenko S

Front Microbiol 2021 ;12:661798

Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.

Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK

Nat Microbiol 2021 Oct ;6(10):1319-1333

Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.

Diener N, Fontaine JF, Klein M, Hieronymus T, Wanke F, Kurschus FC, Ludwig A, Ware C, Saftig P, Bopp T, Clausen BE, Backer RA

Proc Natl Acad Sci U S A 2021 Sep 21 ;118(38)

PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.

Tinoco R, Neubert EN, Stairiker CJ, Henriquez ML, Bradley LM

Front Immunol 2021 ;12:677824

Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning.

Yang WH, Westman JS, Heithoff DM, Sperandio M, Cho JW, Mahan MJ, Marth JD

Proc Natl Acad Sci U S A 2021 Jul 20 ;118(29)

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