Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
– Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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How our immune system controls gut microbes
Researchers from Sanford Burnham Prebys have revealed a new function for a previously-known immune molecule, a discovery with implications for the treatment of autoimmune and gastrointestinal diseases. -
A strange research ecosystem: Discussing Lyme disease with Victoria Blaho
We caught up with Sanford Burnham Prebys assistant professor Victoria Blaho, Ph.D. to talk about why Lyme disease research is important, the progress being made and the work that remains in studying this strange and burdensome disease. -
Laura Martin-Sancho rises to the challenge of COVID-19
The journal Molecular Cell recently asked Laura Martin-Sancho to share her experience working on SARS-CoV-2 during the pandemic. -
COVID-19 vaccines: Our experts weigh in on the historic news
Our leading COVID-19 researchers give their take on the Pfizer vaccine -
COVID-19: Renowned scientist enters clinical trial
After a career of exploring how viruses wreak havoc on our health, researcher now becomes a “subject” in a vaccine study. -
Scientists discover an early sign of type 2 diabetes: Misfolded proinsulin
The findings could lead to tests or treatments that help prevent type 2 diabetes. -
A scientist’s perspective on the coronavirus (COVID-19) pandemic
Infectious disease expert Sumit Chanda tells us how his team is combating the virus, and the advice he gives his loved ones. -
Should you be worried about the never-before-seen coronavirus outbreak?
Here’s what Sumit Chanda, Ph.D., director of Sanford Burnham Prebys’ Immunity and Pathogenesis Program, has to say about the virus spreading fear around the world. -
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases. -
5 lessons I’ve learned from rheumatoid arthritis and why I’m grateful to scientists who can change my world
Angela Durazo was a rising star triathlete. Then a diagnosis with a autoimmune disorder turned her life upside down. -
An evening with autoimmune disorder experts
Three experts—a scientist, a doctor and a patient—shared their perspective on a single topic: autoimmune disorders.
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets.
Cheng K, Martin-Sancho L, Pal LR, Pu Y, Riva L, Yin X, Sinha S, Nair NU, Chanda SK, Ruppin E
Mol Syst Biol 2021 Nov ;17(11):e10260
Global Expansion of Linezolid-Resistant Coagulase-Negative Staphylococci.
Gostev V, Leyn S, Kruglov A, Likholetova D, Kalinogorskaya O, Baykina M, Dmitrieva N, Grigorievskaya Z, Priputnevich T, Lyubasovskaya L, Gordeev A, Sidorenko S
Front Microbiol 2021 ;12:661798
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.
Martin-Sancho L, Tripathi S, Rodriguez-Frandsen A, Pache L, Sanchez-Aparicio M, McGregor MJ, Haas KM, Swaney DL, Nguyen TT, Mamede JI, Churas C, Pratt D, Rosenthal SB, Riva L, Nguyen C, Beltran-Raygoza N, Soonthornvacharin S, Wang G, Jimenez-Morales D, De Jesus PD, Moulton HM, Stein DA, Chang MW, Benner C, Ideker T, Albrecht RA, Hultquist JF, Krogan NJ, García-Sastre A, Chanda SK
Nat Microbiol 2021 Oct ;6(10):1319-1333
Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.
Diener N, Fontaine JF, Klein M, Hieronymus T, Wanke F, Kurschus FC, Ludwig A, Ware C, Saftig P, Bopp T, Clausen BE, Backer RA
Proc Natl Acad Sci U S A 2021 Sep 21 ;118(38)
PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection.
Tinoco R, Neubert EN, Stairiker CJ, Henriquez ML, Bradley LM
Front Immunol 2021 ;12:677824
Neu3 neuraminidase induction triggers intestinal inflammation and colitis in a model of recurrent human food-poisoning.
Yang WH, Westman JS, Heithoff DM, Sperandio M, Cho JW, Mahan MJ, Marth JD
Proc Natl Acad Sci U S A 2021 Jul 20 ;118(29)