Infectious diseases continue to rank high among global mortality factors, especially in developing countries, and systemic inflammation has been identified as a root case of many chronic disorders in the developed world.
“We are in a new era of immunology research. Our increasing understanding of immune cells and their interactions is rapidly leading to new drugs that improve the efficacy of existing drugs and address unmet clinical needs of complex diseases, including cancer.”
– Carl Ware, Ph.D., Center Director
Understanding the fundamentals of inflammation and immunity
Our primary mission is directed at understanding the fundamental mechanisms of inflammation and immunity as the underlying processes essential to host defense and cancer, and the cause of pathologic tissue destruction in autoimmune disease.
Program
Immunity and Pathogenesis Program
By studying how the immune system functions, we can design therapies to manipulate immune cells to fight disease.
Latest news
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A scientist’s perspective on the coronavirus (COVID-19) pandemic
Infectious disease expert Sumit Chanda tells us how his team is combating the virus, and the advice he gives his loved ones. -
Scientists discover an early sign of type 2 diabetes: Misfolded proinsulin
The findings could lead to tests or treatments that help prevent type 2 diabetes. -
Should you be worried about the never-before-seen coronavirus outbreak?
Here’s what Sumit Chanda, Ph.D., director of Sanford Burnham Prebys’ Immunity and Pathogenesis Program, has to say about the virus spreading fear around the world. -
Ebola expert weighs in on news of a potential cure
Sumit Chanda, Ph.D., discusses the recent news of two treatments that saved the lives of people infected with the Ebola virus. -
Digestion-aiding herbs alter gut microbiome
The finding could help uncover new treatments for colon cancer, autoimmune conditions and additional serious diseases. -
An evening with autoimmune disorder experts
Three experts—a scientist, a doctor and a patient—shared their perspective on a single topic: autoimmune disorders. -
5 lessons I’ve learned from rheumatoid arthritis and why I’m grateful to scientists who can change my world
Angela Durazo was a rising star triathlete. Then a diagnosis with a autoimmune disorder turned her life upside down. -
Immune therapy enters Phase 1 clinical trial
Sanford Burnham Prebys Medical Discovery Institute (SBP) today announced that the first healthy subject has been dose
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How can prebiotics help your gut health?
Scott Peterson Ph.D., professor SBP, recently worked with researchers to assess the effects of prebiotics on gut health. -
Cancer immunology symposium highlights hot area in cancer research
The Cancer Immunology and Tumor Microenvironment Symposium held at Sanford Burnham Prebys Medical Discovery Institute
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Viral tricks inspire autoimmune drug design
In the U.S.
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How RNA splicing can trigger cancer
Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of
Publications
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, Pavkov ME, Skupien J, Smiles A, Md Dom ZI, Wilson JM, Park J, Nair V, Schlafly A, Saulnier PJ, Satake E, Simeone CA, Shah H, Qiu C, Looker HC, Fiorina P, Ware CF, Sun JK, Doria A, Kretzler M, Susztak K, Duffin KL, Nelson RG, Krolewski AS
Nat Med 2019 May ;25(5):805-813
Novel Antimycobacterial Compounds Suppress NAD Biogenesis by Targeting a Unique Pocket of NaMN Adenylyltransferase.
Osterman AL, Rodionova I, Li X, Sergienko E, Ma CT, Catanzaro A, Pettigrove ME, Reed RW, Gupta R, Rohde KH, Korotkov KV, Sorci L
ACS Chem Biol 2019 May 17 ;14(5):949-958
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss.
Brunetti G, Storlino G, Oranger A, Colaianni G, Faienza MF, Ingravallo G, Di Comite M, Reseland JE, Celi M, Tarantino U, Passeri G, Ware CF, Grano M, Colucci S
J Pathol 2020 Jan 28 ;
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.
Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, Linington RG, Long JZ, Uhlemann AC, Weerapana E, Fidock DA, Bogyo M
Cell Chem Biol 2020 Jan 21 ;
Identifying determinants of bacterial fitness in a model of human gut microbial succession.
Feng L, Raman AS, Hibberd MC, Cheng J, Griffin NW, Peng Y, Leyn SA, Rodionov DA, Osterman AL, Gordon JI
Proc Natl Acad Sci U S A 2020 Feb 4 ;117(5):2622-2633
Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.
Virgen-Slane R, Correa RG, Ramezani-Rad P, Steen-Fuentes S, Detanico T, DiCandido MJ, Li J, Ware CF
J Immunol 2020 Mar 1 ;204(5):1085-1090
Sensor Sensibility-HIV-1 and the Innate Immune Response.
Yin X, Langer S, Zhang Z, Herbert KM, Yoh S, König R, Chanda SK
Cells 2020 Jan 20 ;9(1)
Co-expression Networks Identify DHX15 RNA Helicase as a B Cell Regulatory Factor.
Detanico T, Virgen-Slane R, Steen-Fuentes S, Lin WW, Rhode-Kurnow A, Chappell E, Correa RG, DiCandido MJ, Mbow ML, Li J, Ware CF
Front Immunol 2019 ;10:2903