Neuroscience and Aging Research Center

Neuroscience and Aging Research Center

Diseases associated with aging and development are already a leading cause of death and disability, and their prevalence is rising fast.

By 2050, the number of Alzheimer’s patients age 65 and older may nearly triple from 5 million to 13.8 million. Our researchers are discovering the etiological pathways as well as small-molecule and stem cell-based treatments to address the clinical unmet need of patients.

 

Translating basic science discoveries into new treatments

Our mission is to translate discoveries from basic molecular research and apply a systems approach to generate breakthrough therapies for devastating neurologic and cardiac diseases.

Programs

Degenerative Diseases Program

Every degenerative disease is associated with misfolded proteins. Studying these proteins provides new clues to protecting our health.

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Development, Aging and Regeneration Program

By building, analyzing and probing models of disease, we can pursue innovative treatment strategies for challenging health conditions.

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Neuroscience Initiative

This Institute-wide effort brings researchers together to apply multi-disciplinary approaches to understand cellular and molecular processes that underlie neurodegenerative diseases.

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Latest news

Publications

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.

Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM

J Clin Med 2019 May 6 ;8(5)

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.

Hernández-Alvarez MI, Sebastián D, Vives S, Ivanova S, Bartoccioni P, Kakimoto P, Plana N, Veiga SR, Hernández V, Vasconcelos N, Peddinti G, Adrover A, Jové M, Pamplona R, Gordaliza-Alaguero I, Calvo E, Cabré N, Castro R, Kuzmanic A, Boutant M, Sala D, Hyotylainen T, Orešič M, Fort J, Errasti-Murugarren E, Rodrígues CMP, Orozco M, Joven J, Cantó C, Palacin M, Fernández-Veledo S, Vendrell J, Zorzano A

Cell 2019 May 2 ;177(4):881-895.e17

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II.

Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, Yao Y, Zhang YW

Exp Mol Med 2019 Jul 23 ;51(7):84

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF

Nat Commun 2019 Jul 2 ;10(1):2923

Peptide-guided nanoparticles for glioblastoma targeting.

Säälik P, Lingasamy P, Toome K, Mastandrea I, Rousso-Noori L, Tobi A, Simón-Gracia L, Hunt H, Paiste P, Kotamraju VR, Bergers G, Asser T, Rätsep T, Ruoslahti E, Bjerkvig R, Friedmann-Morvinski D, Teesalu T

J Control Release 2019 Aug 28 ;308:109-118

Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.

Niazi H, Zoghdani N, Couty L, Leuci A, Nitzsche A, Allende ML, Mariko B, Ishaq R, Aslan Y, Becker PH, Gazit SL, Poirault-Chassac S, Decouture B, Baudrie V, De Candia E, Kono M, Benarab A, Gaussem P, Tharaux PL, Chun J, Provot S, Debili N, Therond P, Proia RL, Bachelot-Loza C, Camerer E

Blood Adv 2019 Jun 11 ;3(11):1702-1713

Membralin deficiency dysregulates astrocytic glutamate homeostasis leading to ALS-like impairment.

Jiang LL, Zhu B, Zhao Y, Li X, Liu T, Pina-Crespo J, Zhou L, Xu W, Rodriguez MJ, Yu H, Cleveland DW, Ravits J, Da Cruz S, Long T, Zhang D, Huang TY, Xu H

J Clin Invest 2019 May 21 ;129(8):3103-3120

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