Aging, Cancer and Immuno-oncology Program

fluorescently stained tumor sample

Cross-talk and cancer

Cancer cells work with their environment to develop strategies that control the growth and spread of cancer.

Fundamental changes in our cells occur with age—and age is a well-recognized risk factor for many, if not most cancers. Once tumors form, they can fool the immune system to escape detection and can even mobilize immune cells to promote their growth. Over time, tumors that do respond to treatment can adapt and become resistant to a therapy that once worked.

Directors' statement

We are defining the changes in cells and their environment that predispose to cancer in aged tissues, and studying the cross-talk between cancer cells, immune cells and stromal components that regulate the growth and metastasis of solid and hematologic malignancies. Our program members are working to apply their knowledge to advance new and more effective preventative interventions and cancer therapies.

Peter Adams, Ph.D. and Linda Bradley, Ph.D., Program Directors

Appointments

Publications

The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.

Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA

Oncotarget 2016 Nov 29 ;7(48):78473-78486

The PI3K pathway in B cell metabolism.

Jellusova J, Rickert RC

Crit Rev Biochem Mol Biol 2016 Sep ;51(5):359-378

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M

Nature 2016 Oct 20 ;538(7625):350-355

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Correction to: Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy.

Yoneyama T, Hatakeyama S, Sutoh Yoneyama M, Yoshiya T, Uemura T, Ishizu T, Suzuki M, Hachinohe S, Ishiyama S, Nonaka M, Fukuda MN, Ohyama C

BMC Cancer 2021 Jan 29 ;21(1):105

Lessons in antiviral immunity.

Hope JL, Bradley LM

Science 2021 Jan 29 ;371(6528):464-465

Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy.

Yoneyama T, Hatakeyama S, Sutoh Yoneyama M, Yoshiya T, Uemura T, Ishizu T, Suzuki M, Hachinohe S, Ishiyama S, Nonaka M, Fukuda MN, Ohyama C

BMC Cancer 2021 Jan 15 ;21(1):72

FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.

Shen JZ, Qiu Z, Wu Q, Finlay D, Garcia G, Sun D, Rantala J, Barshop W, Hope JL, Gimple RC, Sangfelt O, Bradley LM, Wohlschlegel J, Rich JN, Spruck C

Cell 2021 Jan 21 ;184(2):352-369.e23

Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells.

Ramezani-Rad P, Chen C, Zhu Z, Rickert RC

Cell Rep 2020 Nov 17 ;33(7):108403

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