Disease and the immune response
Pathogenesis—literally how disease (pathos) begins (genesis) or develops—is a broad and important area of research.
Many diseases can arise from pathogens, but the immune system protects us through various lines of defense. If the immune system fails to function properly and becomes too weak or too strong, it can lead to disease states that include immunodeficiencies that lead to enhanced susceptibly to infections disease, autoimmune conditions, such as lupus and arthritis, and even cancer.
Our focus is on understanding the regulation and interplay of host immune responses and microbial pathogenesis. We study viral-host interactions, innate and humoral immunity, inflammation and T cell checkpoint regulation. A better understanding of these aspects of the immune system will provide novel therapeutic opportunities to address many unmet medical needs, including the treatment of endemic and pandemic infectious diseases, autoimmune disorders, cancer and inflammatory diseases.
– Sumit Chanda, Ph.D., Program Director
Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.
Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS
Chem Sci 2019 Sep 28 ;10(36):8461-8477
Neelamegham S, Aoki-Kinoshita K, Bolton E, Frank M, Lisacek F, Lütteke T, O'Boyle N, Packer NH, Stanley P, Toukach P, Varki A, Woods RJ, SNFG Discussion Group.
Glycobiology 2019 Aug 20 ;29(9):620-624
Rodriguez-Frandsen A, Martin-Sancho L, Gounder AP, Chang MW, Liu WC, De Jesus PD, von Recum-Knepper J, Dutra MS, Huffmaster NJ, Chavarria M, Mena I, Riva L, Nguyen CB, Dobariya S, Herbert KM, Benner C, Albrecht RA, García-Sastre A, Chanda SK
J Virol 2019 Nov 27 ;
Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.
Hilliard KA, Blaho VA, Jackson CD, Brown CR
FASEB J 2019 Dec 24 ;
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27 ;10(4)
Zhou Y, Zhou B, Pache L, Chang M, Khodabakhshi AH, Tanaseichuk O, Benner C, Chanda SK
Nat Commun 2019 Apr 3 ;10(1):1523
Majer C, Schüssler JM, König R
Med Microbiol Immunol 2019 Aug ;208(3-4):513-529
Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M
J Struct Biol 2019 May 1 ;206(2):149-155
Anderson KL, Swift MF, Hanein D, Volkmann N
Biophys Rev 2018 Dec ;10(6):1571-1575