Tumor Microenvironment and Cancer Immunology Program

fluorescently stained tumor sample

Escaping detection

The tumor microenvironment is filled with noncancerous cells and molecules that are nevertheless an integral part of cancer.

Some tumors hijack these neighbors to help build physical walls around themselves. Many trick the microenvironment to help grow new blood vessels to supply them with energy. Tumors can also fool the immune system to escape detection, and can even mobilize immune cells to promote their growth. 

Director's statement

We are exploring how the interplay between cancer cells, the microenvironment and immune cells regulates the growth and metastasis of solid and hematologic malignancies. Our program members have diverse interests including the microbiome, cell migration/invasion, cell signaling, angiogenesis and immunology; and are highly collaborative, generating new ideas and fresh angles to treat cancer. 

– Linda Bradley, Ph.D., Program Director



The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.

Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA

Oncotarget 2016 Nov 29 ;7(48):78473-78486

The PI3K pathway in B cell metabolism.

Jellusova J, Rickert RC

Crit Rev Biochem Mol Biol 2016 Sep ;51(5):359-378

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B.

Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M

Nature 2016 Oct 20 ;538(7625):350-355

Modulatory Effects of Triphala and Manjistha Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study.

Peterson CT, Pourang A, Dhaliwal S, Kohn JN, Uchitel S, Singh H, Mills PJ, Peterson SN, Sivamani RK

J Altern Complement Med 2020 Sep 18 ;

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH

Cell Rep 2020 Jun 30 ;31(13):107839

Dietary Emulsifier Sodium Stearoyl Lactylate Alters Gut Microbiota <i>in vitro</i> and Inhibits Bacterial Butyrate Producers.

Elmén L, Zlamal JE, Scott DA, Lee RB, Chen DJ, Colas AR, Rodionov DA, Peterson SN

Front Microbiol 2020 ;11:892

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma.

Garancher A, Suzuki H, Haricharan S, Chau LQ, Masihi MB, Rusert JM, Norris PS, Carrette F, Romero MM, Morrissy SA, Skowron P, Cavalli FMG, Farooq H, Ramaswamy V, Jones SJM, Moore RA, Mungall AJ, Ma Y, Thiessen N, Li Y, Morcavallo A, Qi L, Kogiso M, Du Y, Baxter P, Henderson JJ, Crawford JR, Levy ML, Olson JM, Cho YJ, Deshpande AJ, Li XN, Chesler L, Marra MA, Wajant H, Becher OJ, Bradley LM, Ware CF, Taylor MD, Wechsler-Reya RJ

Nat Neurosci 2020 Jul ;23(7):842-853

E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells.

Ramezani-Rad P, Leung CR, Apgar JR, Rickert RC

J Immunol 2020 Mar 15 ;204(6):1535-1542

Parallel Lineage-Tracing Studies Establish Fibroblasts as the Prevailing In Vivo Adipocyte Progenitor.

Cattaneo P, Mukherjee D, Spinozzi S, Zhang L, Larcher V, Stallcup WB, Kataoka H, Chen J, Dimmeler S, Evans SM, Guimarães-Camboa N

Cell Rep 2020 Jan 14 ;30(2):571-582.e2

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