Center for Cardiovascular and Muscular Diseases CCMD
Distinguished Cardiovascular and Muscular Diseases Seminar Series
Speaker
Mark Mercola, PhD
Joan and Sanford I. Weill Scholar
Professor of Cardiovascular Medicine
Stanford Cardiovascular Institute
Seminar Abstract: Very few new medicines are approved for heart disease, even though heart disease is the largest cause of human mortality. Many investigational drugs fail to show effectiveness – driving up the development cost and discouraging investment – and use of human induced pluripotent stem cells (hiPSC) offer a promising way to improve heart disease drug discovery. This talk will cover a) how hiPSC-cardiomyocyte phenotypes predict clinical outcomes from myopathic gene variants, b) using hiPSC models to refine oncology drugs to limit cardiovascular toxicities, and c) combining hiPSC and animal models to develop new treatments for cardiomyopathy and myocardial infarction.