Through rigorous investigation of the genetic mechanisms underlying organogenesis and diseases, our objective is to uncover fundamental insight into basic and biomedical science. We aim to apply these insight towards developing genetic technologies to improve human health and advance human biology.
Genetic mechanism of JAGGED1 mutations in Alagille Syndrome; role of Jagged1 in development and function of the liver, heart, and vasculature; in vivo fluorescent reporter for cellular bilirubin levels; reversal of Alagille Syndrome pathologies; drug screen
Reprogram lineage identity of cells while they reside in the body; mechanism of induced direct transdifferentiation; in vivo generation replacement beta-cells, cardiomyocytes, and neurons from abundant and non-vital tissues; synthetic cell/developmental biology
Explore basic biology using organogenesis as the platform; transcriptional and signaling regulation of lineage specification, pattern formation, differentiation, morphogenesis, and homeostasis; vertebrate evolution; regeneration; aging
In vivo model for rapid, rigorous, and efficient investigation of how genes and chemicals impact vertebrate biology; unique techniques available in zebrafish are necessary to yield new perspectives and insight
Genetic mechanism of JAGGED1 mutations in Alagille Syndrome; role of Jagged1 in development and function of the liver, heart, and vasculature; in vivo fluorescent reporter for cellular bilirubin levels; reversal of Alagille Syndrome pathologies; drug screen
Reprogram lineage identity of cells while they reside in the body; mechanism of induced direct transdifferentiation; in vivo generation replacement beta-cells, cardiomyocytes, and neurons from abundant and non-vital tissues; synthetic cell/developmental biology
Mechanism of genes implicated in diabetes; model monogenic, oligogenic, and polygenic diabetes; rescue genetic models of diabetes based on their individual mechanisms
Explore basic biology using organogenesis as the platform; transcriptional and signaling regulation of lineage specification, pattern formation, differentiation, morphogenesis, and homeostasis; vertebrate evolution; regeneration; aging
In vivo model for rapid, rigorous, and efficient investigation of how genes and chemicals impact vertebrate biology; unique techniques available in zebrafish are necessary to yield new perspectives and insight
Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump JG, Dong PDS
Nat Commun 2017 Oct 3 ;8(1):769Zhang D, Golubkov VS, Han W, Correa RG, Zhou Y, Lee S, Strongin AY, Dong PD
Dev Biol 2014 Nov 1 ;395(1):96-110Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD
Development 2013 Jul ;140(13):2669-79