Malene Hansen, Ph.D.
Malene Hansen's Research Focus
Aging is a fundamental biological reality that is familiar to all of us. But how do organisms age at the molecular level? Several genes and processes have been identified that affect the rate of aging, many of which play important roles in highly conserved signaling pathways with relevance to age-related diseases like cancer and neurodegeneration. However, how these processes and conserved genes affect aging at the cellular and molecular level to influence organismal aging is not fully understood. The Hansen lab's research is directed towards understanding the molecular mechanisms that affect the process of aging.
Using a combination of genetic, cytological and biochemical approaches in the genetically tractable model organism C. elegans as well as in mammalian cell culture, we focus on unraveling how several evolutionarily conserved signaling pathways and processes modulate organismal aging.
A particular focus of the lab is to understand the role of autophagy, a basic cellular process by which cytosolic components are being degraded and recycled (Figure 1), in organismal aging. Autophagy has been linked to many age-related diseases as well as aging, and new molecular insights on how autophagy functions in aging may facilitate future treatments of age-linked disorders, including cancer and neurodegenerative diseases.
Malene Hansen's Bio
Malene Hansen received her early training at the University of Copenhagen in Denmark. She received a Master’s degree in Biochemistry in 1998 and a Ph.D. degree in Molecular Biology in 2001. During this time, Dr. Hansen worked as a trainee in several labs in the US, including the University of North Carolina in Chapel Hill, and The Scripps Research Institute, La Jolla. After her Ph.D, Dr. Hansen trained as a postdoctoral fellow in molecular genetics at the University of California in San Francisco. Dr. Hansen received postdoctoral funding from the Danish National Research Councils as well as an Ellison/American Federation of Aging Research Senior Postdoctoral Fellowship. Dr. Hansen was recruited to Sanford-Burnham Medical Research Institute in September 2007.
Chang JT, Kumsta C, Hellman AB, Adams LM, Hansen M
Elife 2017 Jul 4 ;6
Kumsta C, Chang JT, Schmalz J, Hansen M
Nat Commun 2017 Feb 15 ;8:14337
Wilkinson DS, Jariwala JS, Anderson E, Mitra K, Meisenhelder J, Chang JT, Ideker T, Hunter T, Nizet V, Dillin A, Hansen M
Mol Cell 2015 Jan 8 ;57(1):55-68
Chang JT, Hansen M, Kumsta C
Methods Mol Biol 2020 ;2144:187-200
The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner.
Aparicio R, Hansen M, Walker DW, Kumsta C
Autophagy 2020 Apr ;16(4):772-774
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Kumsta C, Chang JT, Lee R, Tan EP, Yang Y, Loureiro R, Choy EH, Lim SHY, Saez I, Springhorn A, Hoppe T, Vilchez D, Hansen M
Nat Commun 2019 Dec 11 ;10(1):5648
Getting under the skin: Cuticle damage elicits systemic autophagy response in <i>C. elegans</i>.
Kumsta C, Hansen M
J Cell Biol 2019 Dec 2 ;218(12):3885-3887
Zhou B, Kreuzer J, Kumsta C, Wu L, Kamer KJ, Cedillo L, Zhang Y, Li S, Kacergis MC, Webster CM, Fejes-Toth G, Naray-Fejes-Toth A, Das S, Hansen M, Haas W, Soukas AA
Cell 2019 Apr 4 ;177(2):299-314.e16
Hansen M, Rubinsztein DC, Walker DW
Nat Rev Mol Cell Biol 2018 Sep ;19(9):611