Michael Jackson, Ph.D.

Michael Jackson

Michael Jackson, Ph.D.

Senior Vice President, Drug Discovery and Development

Michael Jackson's Research Focus

Drug Discovery, Drug Delivery
Cell Biology

Dr. Jackson is senior vice president of drug discovery and development at Sanford Burnham Prebys Medical Discovery Institute, where he oversees the bicoastal operations of the Prebys Center, an approximately 80-person Drug Discovery enterprise embedded in the Institute. The center is equipped with state of the art ultra High Throughput Drug Screening (HTS) and lead discovery capabilities. His overall goal is to generate a pipeline of first in class small molecule therapeutics based on the break through discoveries on the molecular basis of disease made by investigators at the institute and collaborators.

Upon joining SBP in 2009 Dr. Jackson managed and then lead as Principal Investigator, SBP’s NIH-funded Molecular Libraries Probe comprehensive center which successfully executed over 100 HTS campaigns with collaborators across the Nation. Over a six year period the center generating >30 million screening data points and produced over 60 chemical probe reports published through the NCBI bookshelf. Since the Molecular libraries program ended the Prebys Center has continued to operate in a highly collaborative framework with investigators from many academic institutes and biopharmaceutical companies, it continues to conduct HTS screens against > 25 targets each year in search of drug leads to advance to therapeutics. Dr. Jackson is integrally involved in the center’s outreach and translational efforts that include over 35 ongoing collaborations, supported by grants, collaborations and contracts.

Dr. Jackson works closely with SBP’s senior leadership to seek new avenues of support for preclinical and clinical drug development initiatives to enable the overall mission of the Institute to translate basic research to new products.

Michael Jackson's Bio

Dr. Jackson brings many years of drug discovery and development experience to Prebys Center. Prior to joining Sanford-Burnham in 2009, Dr. Jackson spent 15 years working within Johnson & Johnson’s pharmaceutical research organization. He managed cross-disciplinary teams of scientists focused on discovering chemical leads and clinical candidates directed at novel first-in-class drug targets. In 1999, he took on the role of vice president of discovery research at Johnson & Johnson’s La Jolla, California location, where he establish a state-of-the-art drugs discovery institute. As site head, Dr. Jackson oversaw all aspects of the new institute, from building design to hiring the staff of 300 scientists. In 2001 Dr. Jackson’s responsibility was expanded and as senior vice president of drug discovery at Johnson & Johnson Pharmaceutical Research and Development (U.S.) he was responsible > 800 hundred drug discovery scientists spread over five sites in the United States. Under his leadership, this organization advanced many clinical candidates into development across 5 multiple therapeutic areas including CNS, Pain, Immunology, CV disease. In 2005, Dr. Jackson was appointed President of ALZA Corporation, a large biotech company acquired by Johnson & Johnson that focused on drug delivery. As president of ALZA, he was responsible for all aspects of a 1,200 person research and development organization, successfully gaining regulatory approval for multiple drug delivery products that leverage the Oros technology and a first in class iontophoretic patch for the treatment of pain. 

Prior to his industry career Dr. Jackson was an assistant professor at The Scripps Research Institute, where he published widely in the fields of cell biology and immunology. His work included identification of motifs that direct intracellular targeting of proteins to subcellular organelles, and the relevance of this and protein folding to antigen presentation and processing in the immune system. He received his Ph.D. from the Department of Biochemistry at the University of Dundee in Scotland. 
 

Career Highlights 

  • Managed (2009-2012) and then lead as P.I (2013-2014), Sanford Burnham’s NIH funded U54 grant Molecular libraries comprehensive screening center. 
  • Led the transformation of the Prebys center from a chemical biology and probe production organization to a full capable drug discovery operation generating first in class small molecule drug leads/NME’s. 
  • Instrumental in securing the Institutes first major multi-year, multi PI/project thematic translational collaboration with a pharmaceutical company. 
  • Instrumental in establishing the Florida Translational Research Program – a multi year contract from the department of health/State of Florida supporting SBP translational drug discovery program in Orlando. 
  • Developed and executed “first of a kind” collaborative translational agreements with the Mayo clinic. 
  • Key member of the executive team that established a 10-year plan for the Institute that defined a path to sustainability. This plan was instrumental in securing an anonymous donation to the Institute of $275MM in January 2014. 
  • Established a pipeline of first in class therapeutics leads, the first product of this pipeline was licensed to Daiichi Sankyo in 2015. 
  • Key interface between the Institute and philanthropist Conrad Prebys, which resulted in a $100MM donation to the Institute in 2015
  • Instrumental is establishing a regional drug discovery effort for Alzheimer’s disease in collaboration with Alzheimer’s San Diego, Mayor’s office San Diego and SD County Supervisor.

CMSN Accessory

Publications

Cloning of cDNAs coding for rat hepatic microsomal UDP-glucuronyltransferases.

Jackson MR, McCarthy LR, Corser RB, Barr GC, Burchell B

Gene 1985 ;34(2-3):147-53

Induction of UDP-glucuronyl transferase mRNA in embryonic chick livers by phenobarbital.

Jackson MR, Kennedy SM, Lown G, Burchell B

Biochem Pharmacol 1986 Apr 1 ;35(7):1191-8

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Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

Pinkerton AB, Peddibhotla S, Yamamoto F, Slosky LM, Bai Y, Maloney P, Hershberger P, Hedrick MP, Falter B, Ardecky RJ, Smith LH, Chung TDY, Jackson MR, Caron MG, Barak LS

J Med Chem 2019 Sep 12 ;62(17):8357-8363

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA

Cancer Lett 2019 May 1 ;449:145-162

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

Pinkerton AB, Sergienko E, Bravo Y, Dahl R, Ma CT, Sun Q, Jackson MR, Cosford NDP, Millán JL

Bioorg Med Chem Lett 2018 Jan 1 ;28(1):31-34

Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1.

Rong J, Pass I, Diaz PW, Ngo TA, Sauer M, Magnuson G, Zeng FY, Hassig CA, Jackson MR, Cosford ND, Matsuzawa S, Reed JC

J Biomol Screen 2015 Dec ;20(10):1232-45

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA, NIH Molecular Libraries Project Team.

Cell 2015 Jun 4 ;161(6):1252-65

Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.

Sheen CR, Kuss P, Narisawa S, Yadav MC, Nigro J, Wang W, Chhea TN, Sergienko EA, Kapoor K, Jackson MR, Hoylaerts MF, Pinkerton AB, O'Neill WC, Millán JL

J Bone Miner Res 2015 May ;30(5):824-36

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