Human Archives - Sanford Burnham Prebys

Related Disease
Cardiomyopathies, Cardiovascular Diseases

Anatomical Systems and Sites
Cardiovascular System, General Cell Biology, Heart

Research Models
Computational Modeling, Drosophila, Human

Techniques and Technologies
Bioinformatics, Cell Biology, Confocal Microscopy, Fluorescence Microscopy, Genetics, In vivo Modeling, Live Cell Imaging, Live Imaging, Microscopy and Imaging, Molecular Biology, RNA Interference (RNAi), Systems Biology, Transgenic Organisms

Related Disease
HIV/AIDS, Infectious Diseases, Molecular Biology

Phenomena or Processes
Host-Pathogen Interactions, Infectious Disease Processes, Inflammation, Innate Immunity

Anatomical Systems and Sites
Immune System and Inflammation

Research Models
Clinical and Transitional Research, Computational Modeling, Human, Human Cell Lines, Mouse, Mouse Cell Lines, Primary Cells, Primary Human Cells

Techniques and Technologies
Biochemistry, Bioinformatics, Cellular and Molecular Imaging, Drug Discovery, Drug Efficacy, Gene Expression, Gene Knockout (Complete and Conditional), Gene Silencing, High-Throughput/Robotic Screening, RNA Interference (RNAi), Systems Biology

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Kevin Tharp studies the interplay between mitochondrial metabolism and the physical properties of the tumor microenvironment, using genetically engineered mouse models and bioengineered human tumor models to define the mitochondrial programming unique to cancer cells in the tumor microenvironment.

His goal is to develop new therapies that block the metabolic adaptations that cancer cells use to metastasize, a major cause of cancer-associated mortality.

“I study how cells make decisions about their metabolic programming, which I expect will enable us to develop new therapeutics against metastatic tumor cells.”

Tharp previously worked as a postdoctoral scholar in the Center for Bioengineering & Tissue Regeneration at UCSF Health.

He completed his PhD in metabolic biology at UC Berkeley and his Bachelor of Science degree in biochemistry and molecular biology at UC Santa Cruz, where he graduated with honors and the Dean’s Award in Chemistry.

He has received meritorious funding awards from the Sandler Foundation and the National Institutes of Health/National Cancer Institute for his postdoctoral research.

Google Scholar profile

Timothy Huang completed his PhD at the University of Calgary (Canada) under Dr. Dallan Young, studying kinase pathways involved in mediating cell polarity in yeast. He studied mechanisms underlying actin cytoskeletal dysfunction in Alzheimer’s disease at Scripps with Dr. Gary Bokoch (La Jolla), before joining Dr. Huaxi Xu’s laboratory in 2012/2013.

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Lukas Chavez is an Associate Professor at the Sanford Burnham Prebys. He is also the Director of the Clayes Research Center for Neuro-Oncology at the Institute for Genomic Medicine at the Rady Children’s Hospital, San Diego. In this role, he works with a team of physicians and scientists to capture genomic, transcriptomic, epigenetic and functional data from pediatric brain tumor patients, and uses this information to improve diagnosis and treatment. His research interests focus on structural variants as well as circular extrachromosomal DNA (ecDNA) in childhood cancers. These extrachromosomal DNA circles are frequently found in highly aggressive solid tumors and represent a new target for improved therapeutic approaches.

Education

2010: PhD, Free University, Berlin

Honors and Recognition

2020: St. Baldrick’s Scholar Award, St. Baldrick’s Foundation
2019: Award of Excellence in Pediatric Neuro-Oncology, Society of Neuro-Oncology
2012–2015: Feodor-Lynen Fellowship for Postdoctoral Researchers, Alexander-von-Humboldt Foundation

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Showing 1 of 1

3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma.

Okonechnikov K, Camgöz A, Chapman O, Wani S, Park DE, Hübner JM, Chakraborty A, Pagadala M, Bump R, Chandran S, Kraft K, Acuna-Hidalgo R, Reid D, Sikkink K, Mauermann M, Juarez EF, Jenseit A, Robinson JT, Pajtler KW, Milde T, Jäger N, Fiesel P, Morgan L, Sridhar S, Coufal NG, Levy M, Malicki D, Hobbs C, Kingsmore S, Nahas S, Snuderl M, Crawford J, Wechsler-Reya RJ, Davidson TB, Cotter J, Michaiel G, Fleischhack G, Mundlos S, Schmitt A, Carter H, Michealraj KA, Kumar SA, Taylor MD, Rich J, Buchholz F, Mesirov JP, Pfister SM, Ay F, Dixon JR, Kool M, Chavez L

Nat Commun 2023 Apr 21 ;14(1):2300