Andrei Osterman is a Professor in the Immunity and Pathogenesis Program Program at the Infectious and Inflammatory Disease Center of Sanford Burnham Prebys (since August 2003). He received his doctorate from Moscow State University in 1983, did postdoctoral work UT Southwestern Medical Center, and held the position of the Director and then Vice President of Research at Integrated Genomics in 1999-2003. Dr. Osterman is one of the founders of the Fellowship for Interpretation of Genomes (FIG), a nonprofit research organization that launched the Project to Annotate 1,000 Genomes in 2003. FIG provides the open-source integration of all publicly available genomes and tools for their comparative analysis, annotation, and metabolic reconstruction.
Related Disease
Breast Cancer, Cancer, Infectious Diseases, Radiation Damage, Skin Cancer and Melanoma
The main focus of Dr. Osterman’s research team is on fundamental and applied aspects of the key metabolic subsystems in a variety of species, from bacteria to human. This group uses a systems biology approach to reconstruct and explore metabolic and transcriptional regulatory networks. This approach combines comparative genomics and other bioinformatic techniques with biochemical and genetic experiments for pathway, gene and target discovery. Using this approach this group predicted and experimentally verified numerous enzyme families in the metabolism of cofactors, carbohydrates, and amino acids. Recent breakthroughs included prediction and characterization of novel transporters, transcriptional regulators and carbohydrate utilization pathways in a number of model bacterial systems. Applications in the field of infectious disease include identification of novel drug targets and structure-based development of novel anti-infective agents. New directions in cancer research are based on application of metabolic profiling technology for identification of novel diagnostic and therapeutic targets. Other directions of the on-going research include bioinformatics of regulatory proteolysis and applications of structural modeling for exploration of metabolic networks and gene discovery.
- Oct 2, 2024
Gut microbiome repair in children with severe acute malnutrition
Oct 2, 2024Researchers around the world, including Andrei Osterman, have been investigating potential remedies for child malnutrition.
- Aug 13, 2024
Dodging AI and other computational biology dangers
Aug 13, 2024Sanford Burnham Prebys scientists say that understanding the potential pitfalls of using artificial intelligence and computational biology techniques in biomedical…
- Aug 8, 2024
Scripting their own futures
Aug 8, 2024At Sanford Burnham Prebys Graduate School of Biomedical Sciences, students embrace computational methods to enhance their research careers
- Aug 1, 2024
Objective omics
Aug 1, 2024Although the hypothesis is a core concept in science, unbiased omics methods may reduce attachments to incorrect hypotheses that can…
- Mar 6, 2024
What makes a pathogen antibiotic-resistant?
Mar 6, 2024Researchers compared two common bacterial foes and two specific drugs, looking for deeper explanations and clinical implications
- Jan 8, 2024
A potential new weapon against a deadly, drug-resistant bacterial pathogen
Jan 8, 2024Carbapenems are a class of highly effective antibiotics that are often used to treat severe bacterial infections. They are usually…
Select Publications
Showing 3 of 3Functional specialization in proline biosynthesis of melanoma.
De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL, Smith JW
PLoS One 2012 ;7(9):e45190Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.
Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW
Pigment Cell Melanoma Res 2012 May ;25(3):375-83Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.
Scott DA, Richardson AD, Filipp FV, Knutzen CA, Chiang GG, Ronai ZA, Osterman AL, Smith JW
J Biol Chem 2011 Dec 9 ;286(49):42626-42634