Alexandre Colas Archives - Sanford Burnham Prebys
Institute News

Sanford Burnham Prebys recognizes 10 doctoral degree recipients

AuthorCommunications
Date

June 3, 2026

The Institute’s Graduate School of Biomedical Sciences held its third Commencement ceremony to celebrate new alumni

The Sanford Burnham Prebys Medical Discovery Institute’s Graduate School of Biomedical Sciences hosted 10 recent doctoral degree recipients and their family members, friends and colleagues during the school’s third annual Commencement ceremony on May 29, 2026.

These new graduates join the ranks of Institute scientists and alumni that have propelled 50 years of discovery at Sanford Burnham Prebys and 20 years of graduate education.

The graduation ceremony was held at the Institute’s La Jolla campus in the Victor E. LaFave III Memorial Auditorium.

“As you reflect on your first days as a graduate student, I hope you recognize how far you have come, not only as scientists, but also as thinkers, collaborators, mentors and individuals,” said Alessandra Sacco, PhD, the dean of the Sanford Burnham Prebys Graduate School of Biomedical Sciences and a professor in the Center for Cardiovascular and Muscular Diseases.

“The growth you have demonstrated through this remarkable journey is extraordinary, and today we celebrate both your accomplishments and the dedication that made them possible. It has been an honor to be part of your journey.”

Following her remarks, Sacco introduced David Brenner, MD, the president and CEO of Sanford Burnham Prebys.

“Yesterday, you were graduate students, today you are graduates and tomorrow you are alumni,” Brenner said. “I want you to feel like this is your second home where you’ll return as peers and colleagues to tell us about your triumphs and contribute to our seminars and symposia as active members of our community.” 

Following Brenner’s comments, Michaela Romero, PhD ’25, spoke on behalf of her fellow graduates.

“Here at Sanford Burnham Prebys, we’ve been immersed in a culture of collaboration where science is not a solo act,” Romero said. “This has not happened by accident and has been built one conversation at a time. 

“Cultures like this need to be nurtured with care, so I hope you create something that feels just as special as this place wherever you go in the future.” 

Romero turned the podium over to Cosimo Commisso, PhD, the deputy director of the Institute’s NCI-Designated Cancer Center and a professor in the Cancer Metabolism and Microenvironment Program, who provided the Commencement address.

Commisso spoke about the importance of carefully contemplating the motivation behind your science and how it can change over time, which he punctuated with a story from his scientific journey about an event he attended for pancreatic cancer patients, survivors and their family members.

“I gave myself permission to evolve and realized that I wanted to dedicate my life’s work specifically to pancreatic cancer research,” he said. “If something like this happens to you, if such an event impacts you in a profound way, I hope you listen to your internal compass and remember that what motivates you today at graduation may likely look very different years later. 

“Evolution of your ‘why’ is a feature and not a bug,” he added. “Let your own ‘why’ be the force that pushes you beyond the familiar to make a difference.”

Diane Klotz, PhD, the chief learning officer at Sanford Burnham Prebys, then provided attendees an overview of the meaning of the hoods and symbols that are used in Commencement ceremonies. She asked faculty members to place the doctoral academic hoods upon the graduates to signify completion of their degrees.

This year, the following graduates were acknowledged:

  • Adarsh Rajesh, PhD ’25, who trained in the Adams lab and was hooded by Peter Adams, PhD, director of and professor in the Cancer Genome and Epigenetics Program
  • Sviatlana Zaretski, PhD ’25, who trained in the Adams lab and was hooded by Adams
  • Yu-Ling (Linda) Chang, PhD ’26, who trained in the Colas lab and was hooded by Alexandre Colas, PhD, associate dean of admissions in the Graduate School of Biomedical Sciences and associate professor in the Center for Cardiovascular and Muscular Diseases
  • Michaela Romero, PhD ’25, who trained in the Colas lab and was hooded by Colas
  • Jiaqian (Emily) Wu, PhD ’25, who trained in the Cosford lab and was hooded by Nicholas Cosford, PhD, professor in the Cancer Metabolism and Microenvironment Program
  • Ximena Diaz-Olea, PhD ’25, who trained in the Ronai lab and was hooded by Andrei Osterman, PhD, her thesis committee chair, vice dean and associate dean of curriculum of the Graduate School of Biomedical Sciences and a professor in the Center for Metabolic and Liver Diseases
  • Cedomir Stamenkovic, PhD ’25, who trained in the Sacco lab and was hooded by Sacco
  • Rema Iyer, PhD ’25, who trained in the Deshpande lab and was unable to attend the ceremony
  • Utkarsha Hemant Paithane, PhD ’26, who trained in the Bagchi lab and was unable to attend
  • Ruslan Nuryyev, PhD ’26, who trained in the Snyder lab and was unable to attend

Graduate school vice dean Osterman provided the ceremony’s closing remarks.

“What is happening today is because of your genuine accomplishment and is a product of your creativity, genius, effort and everything you invested in the research project that you completed,” Osterman said. 

“Now you will take all you have learned during your time here and choose your own path forward, and a new and exciting adventure begins.”

Institute News

Sanford Burnham Prebys goes Inside the Science of Heart Disease

AuthorCommunications
Date

April 21, 2026

Event recording now available for panel discussion with scientists held on April 15, 2026

David Brenner, MD, president and CEO of Sanford Burnham Prebys Medical Discovery Institute, welcomed members of the San Diego community to the first “Inside the Science” event held on April 15, 2026. This Discovery Series community engagement program offered a behind-the-scenes look at cardiovascular research.

Attendees participated in an afternoon exploring exciting developments in translating science into heart health. Kurt Marek, PhD, the chief research development officer at Sanford Burnham Prebys, moderated the discussion among three featured panelists:

  • Alexandre Colas, PhD, associate professor in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys and associate dean of admissions for the Graduate School of Biomedical Sciences
  • Ehtisham Mahmud, MD, professor and division chief of Cardiovascular Medicine at UC San Diego Health and the Edith and William Perlman Chair in Cardiology and executive director of the University of California San Diego Cardiovascular Institute
  • Sanjeev Ranade, PhD, assistant professor in the Center for Cardiovascular and Muscular Diseases at Sanford Burnham Prebys

The program explored how heart disease develops across the lifespan from genetic and early-life factors to aging-related conditions. It also highlighted emerging research and new treatments to repair the heart and improve patient outcomes.

Ehtisham Mahmud, Sanjeev Ranade and Alexandre Colas during panel discussion. Image credit: Sanford Burnham Prebys.

Ranade discussed his research regarding the causes of congenital heart defects. Image credit: Sanford Burnham Prebys.

Watch Recording

Please sign up for the institute’s newsletter to be notified about future events. Recordings of past events are available online.

While there is no cost to attend “Inside the Science” events, philanthropy is vital to advancing the institute’s mission of improving human health through bold, innovative science.

Please consider a gift to help extend the Sanford Burnham Prebys mission to drive discoveries that improve lives.

Institute News

Alexandre Colas named 2024 Mentor of the Year at Sanford Burnham Prebys

AuthorGreg Calhoun
Date

October 8, 2024

Colas was applauded for enthusiastically promoting mentees’ professional and scientific development.

Alexandre Colas, PhD, was named as the 2024 Mentor of the Year at Sanford Burnham Prebys. This honor is jointly awarded by the institute’s Office of Education, Training and International Services (OETIS) and the Postdoctoral Training Advisory Group (PTAG).

Colas is the associate dean of admissions for the Sanford Burnham Prebys Graduate School of Biomedical Sciences and associate professor in the institute’s Development, Aging and Regeneration Program.

The Mentor of the Year awardee was determined following a selection process driven by postdoctoral scholars. After a committee reviewed nomination letters submitted by postdoctoral associates and graduate students, Colas was announced as the recipient on September 19 at the 23rd Annual Biomedical Research Symposium.

“It is evident that Colas has remarkable mentorship skills and a genuine commitment to fostering both the scientific and professional development of his postdocs and graduate students,” said postdoctoral associate and PTAG representative Alicia Llorente Lope, PhD, during her presentation of the Mentor of the Year award.

“Colas’ nominators described him as kind, compassionate and someone who creates a positive, collaborative and intellectually stimulating environment in his lab. His enthusiasm for science is infectious, and it inspires those around him.”

Additional comments from Colas’ nominators include:

“He promotes participation in career development and events, encouraging all his mentees to attend scientific workshops and training events, conferences, talks and symposia that will benefit our scientific and personal growth.”

“As an enthusiastic leader, Colas organized events to celebrate achievements and milestones. He used these opportunities to promote team-building and collaborative efforts among his lab members and beyond the lab.”

“Whether discussing complex scientific hypotheses or the latest developments in our field, Colas has a unique ability to make even the most challenging concepts accessible and exciting.”

“His influence and guidance have allowed me to push myself outside my comfort zone and to become a better scientist.”

“He guides students through difficulties, offering thoughtful advice and constructive feedback that helps us overcome obstacles and strengthens our resilience and confidence as researchers. His mentorship has helped me achieve great scientific discoveries in the lab and grow closer to becoming an independent research scientist.”

“Should I establish my own lab, I aspire to follow Colas’ mentoring and leadership style, which I believe is the epitome of mentoring perfection.”

Institute News

Scientists unite to get to the heart of AFib

AuthorSusan Gammon
Date

August 15, 2023

A collaborative study led by researchers at Sanford Burnham Prebys is paving the way to identifying gene networks that cause atrial fibrillation (AFib), the most common age-related cardiac arrhythmia.

The findings, published in Disease Models & Mechanisms, validate an approach that combines multiple experimental platforms to identify genes linked to an abnormal heart rhythm.

“One of the biggest challenges to solving the AFib genetic puzzle has been the lack of experimental models that are relevant to humans,” says Alex Colas, PhD, co-senior author and assistant professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “By working with colleagues who focus on AFib but in different systems, we have created a robust multiplatform model that can accurately pinpoint genes associated with this condition.”

AFib is characterized by an irregular, rapid heartbeat that causes a quivering of the upper chambers of the heart, called the atria. This condition is the result of a malfunction in the heart’s electrical system that can lead to heart failure and other heart-related complications, which include stroke-inducing blood clots.

AFib impacts more than 5.1 million people in the United States, with expectations of 15.9 million by 2050. It is more common in individuals over the age of 60 but can also occur in teenagers and young adults.

“There will never be a one-size-fits-all solution to AFib, since it can be caused by many different genes—and the genes that do cause it vary from person to person,” says Karen Ocorr, PhD, also a co-senior author and assistant professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “A better understanding of the gene network(s) that contribute to AFib will help us design tests to predict a person’s risk, and develop individualized approaches to treat this dangerous heart condition.”

To overcome the limitations of current AFib research models, Colas, Ocorr and researchers from UC Davis and Johns Hopkins University combined forces to assemble a multi-model platform that combines:

  • A high-throughput screen using atrial-like cells (derived from human-induced pluripotent stem cells) to measure how a gene mutation alters the strength and duration of a heartbeat.
  • A Drosophila (fruit fly) model—with heart genetics and development remarkably similar to human hearts—that permits analysis of gene mutations in a functioning organ.
  • A well-established computational model that uses computers to simulate the effects of gene mutations on the electrical activity in human atrial cells.

The accuracy of the multi-model platform was confirmed when each screened 20 genes, and all three platforms identified phospholamban, a protein found in the heart muscle with known links to AFib.

“This collaboration has greatly expanded our ability to understand AFib at the genetic level,” says Colas. “Importantly, the high-throughput screening component of the model will also allow us to rapidly and effectively screen for drugs that can restore a heart to its normal rhythm.”

He adds, “Hopefully this is just the beginning. There are many more cardiac diseases to which our system can be applied.”

Institute News

NIH grant aims to boost heart muscle

AuthorMonica May
Date

August 23, 2019

Heart disease is the number one killer of Americans. Now, the National Institutes of Health (NIH) has awarded a four-year grant totaling nearly half a million dollars to Sanford Burnham Prebys to find medicines that could help people repair damaged heart muscle—and potentially reduce the risk of heart attack or other cardiovascular events. 

“Each year we lose far too many loved ones to heart attacks and other heart conditions,” says grant recipient Chris Larson, PhD, adjunct associate professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys. “Now, we have the opportunity to find medicines that may help more people live long, active lives by strengthening their heart muscles.”

Nearly half of American adults—approximately 120 million people—have cardiovascular disease, according to the American Heart Association and NIH. The condition occurs when blood vessels that supply the heart with oxygen and nutrients become narrowed or blocked, increasing risk of a heart attack, chest pain (angina) or stroke. Current medications for cardiovascular disease can lower blood pressure or thin the blood to minimize risk. Still, five years after a heart attack, 47% of women and 36% of men will die, develop heart failure or experience a stroke. No medicines that repair heart muscle exist. 

To identify drugs that may stimulate heart muscle growth, Larson and his team will screen hundreds of thousands of compounds against human heart muscle cells, called cardiomyocytes. The work will be done in collaboration with Alexandre Colas, PhD, assistant professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys, who developed the high-throughput screening system that will be employed.

Once the scientists identify drug candidates that promote heart muscle growth, they will study these compounds in additional cellular and animal models of heart disease in the hopes of uncovering insights into the biology behind the repair process. 

“After experiencing a heart attack or other cardiovascular event, many people live in fear that it will happen again,” says Colas. “Today we embark on a journey toward a future where people living with cardiovascular disease don’t have to be afraid of a second heart attack.”