CendR Archives - Sanford Burnham Prebys
Institute News

Year in review: SBP highlights from 2018

AuthorMonica May
Date

December 17, 2018

The science never stops at Sanford Burnham Prebys Medical Discovery Institute (SBP), and 2018 was no different. 

From an Alzheimer’s breakthrough to advancing promising medicines for pancreatic cancer and autoimmune disorders, our hardworking scientists were busy at the bench and beyond. As the year comes to a close, we are sharing a selection of our most widely read stories from the past 12 months. 

1.    Scientists uncover a potential near-term treatment for Alzheimer’s disease 
Jerold Chun, MD, PhD, and his team revealed that never-before-seen DNA recombination in the brain is linked to Alzheimer’s disease. The research suggests that existing FDA-approved drugs to treat HIV might hold potential as near-term Alzheimer’s treatments and provide an explanation for why previous clinical trials for Alzheimer’s disease have failed. The study was published in Nature.

2.    SBP women awarded American Heart Association Fellowships
The American Heart Association awarded grants to three SBP scientists. This funding advances projects that align with the organization’s mission of building healthier lives, free of cardiovascular disease and stroke. 

3.    Compound discovered at SBP enters Phase 1 clinical trial for pancreatic cancer
Solid tumors are often surrounded by thick fibrotic walls, making it hard for treatments to get access to the tumor cells. CEND-1, a drug candidate discovered in the lab of Erkki Ruoslahti, MD, PhD, has entered a Phase 1 clinical trial for metastatic pancreatic cancer. CEND-1 streamlines the delivery of cancer drugs deep into tumors. CEND-1 was licensed to the private company DrugCendR Inc. in 2015. 

4.    Scientists solve a medical mystery
Hudson Freeze, PhD, and his team joined collaborators around the globe to crack the case of Saul-Wilson syndrome, a rare form of dwarfism with an unknown cause. Now, the 14 known people with the syndrome and their families have answers: A gene alteration that affects the cell’s protein packager, the Golgi complex, causes the condition. 

5.    Immune therapy developed through SBP and Lilly collaboration enters Phase 1 clinical trial
A therapy that arose from a research collaboration between Eli Lilly and Company (Lilly) and SBP entered a Phase 1 clinical trial. The therapy is a biologic that inhibits inflammation—a common response linked to autoimmune diseases such as rheumatoid arthritis, lupus and inflammatory bowel disease.

Interested in keeping up with SBP’s latest discoveries, upcoming events and more? Subscribe to our monthly newsletter, Discoveries.

To help SBP scientists focus on pioneering research that transforms human health, donate now. 

Institute News

Unique pathway that homes cancer drugs to tumors is like no other

Authorsgammon
Date

October 3, 2014

In a new study published in Nature CommunicationsErkki Ruoslahti, MD, Ph.D., and his research team, with Hongbo Pang, PhD, as the lead author, identify the unique pathway that enhances the delivery of anti-cancer drugs to tumors. The pathway, called CendR, is a previously unknown variation of endocytosis—the process by which cells engulf nutrients and extracellular molecules. When activated, the CendR system improves the therapeutic efficacy of existing anti-cancer drugs while minimizing the collateral damage of normal cells and tissue. The findings advance our understanding of the biology of the cell by establishing a new type of trans-tissue transport pathway. Continue reading “Unique pathway that homes cancer drugs to tumors is like no other”