This annual award was established in 2024 to recognize the contributions of postdoctoral fellows at Sanford Burnham Prebys.

Chiara Nicoletti, PhD, a postdoctoral associate at Sanford Burnham Prebys, was selected as the first recipient of the Fishman Fund Cynthia Schwartz Shenkman Research Excellence Award. 

This award is one of two new honors being given during the 23^rd Fishman Funds awards ceremony on September 17, marking 2024 as a special year for the Institute and the supporting donors.  

The inaugural Don Barach Fishman Fund Career Award adds a fourth prize in the category of career awards focused on providing professional development opportunities for postdoctoral fellows. In addition, the Fishman Fund Cynthia Schwartz Shenkman Research Excellence Award adds a new third category of honors.  

This award recognizes and rewards experienced postdoctoral fellows who have achieved a track record of research excellence. It is designed to help offset the cost of living in the region, and to benefit recipients as they prepare for the next step in their careers.

“For me, this award provides recognition of my hard work and that of my colleagues,” said Nicoletti. “It also acknowledges my mentor at Sanford Burnham Prebys and how he supports members of his laboratory.”

Nicoletti studies epigenetic patterns in skeletal muscle development and disease in the laboratory of Pier Lorenzo Puri, MD, director of the Development, Aging and Regeneration Program.

“My graduate school mentor met Lorenzo at a conference in 2016,” said Nicoletti. “Lorenzo wanted to apply what was then a very new technique called Hi-C to better understand how the MyoD protein—a key player in the establishment of muscle cell identity—is able to transform non-muscle cells into muscle.

“He wanted to study how changes in the three-dimensional organization of DNA can trigger alterations in gene expression, leading to a switch in cell identity. Few people in the world could analyze the data from these experiments at that time. And one of those people was me.”

Chiara’s accomplishments since joining Sanford Burnham Prebys and the Puri lab in 2018 include her work on dysferlinopathy, a rare form of muscular dystrophy. In collaboration with the laboratory of Jyoti K. Jaiswal, MSc, PhD, at Children’s National Research Institute in Washington, D.C., she developed an atlas mapping how the disease causes changes in the transcription of genes in skeletal muscle. This compendium follows the disease progression of dysferlinopathy at the single-cell level.

Dysferlinopathy patients suffer from progressive muscle loss in which muscle cells are replaced by fat and scar tissue. Understanding how this process takes place may accelerate research to find new drugs to improve muscle function. For her work on this project, Nicoletti was recently recognized with the Young Investigator Award by the Jain Foundation, a nonprofit foundation focused on finding a cure for dysferlinopathy.

“When you get to know people with muscular dystrophy, you immediately see that their minds are bursting with life,” reflected Nicoletti. “Someone I met recently said his dream was to bring his daughter to the altar at her wedding and have a father-daughter dance. If we can do something to improve his quality of life, imagine the ripple effects of what that would mean to his daughter, to his whole family.”

When Nicoletti completes her postdoctoral fellowship, she would like to remain in academia as an independent principal investigator.

“As a bioinformatician with experience in bench research, I hope to bring different labs together to build interdisciplinary collaborations focused on how diverse biological systems and organs interact.

“I also would like to teach as I feel it is our fundamental duty as scientists to train the next generation. I believe it is especially important to educate students and postdoctoral fellows about basic bioinformatics skills so that they are better equipped to evaluate published data and collaborate with computational biologists.”

Nicoletti also expressed a long-term goal of applying computational biology methods to advance knowledge of why patients are more or less susceptible to disease and have different responses to medications. These learnings are critical to personalizing treatment plans for individuals rather than populations.

Nicoletti is thankful for the support of the Fishman Fund Cynthia Schwartz Shenkman Research Excellence Award during the remainder of her postdoctoral training.

“The work I do is very rewarding. It feels close to the best that humanity has to offer when scientists and patients collaborate to achieve a common goal.

“I’m so grateful for this award, which serves as even more motivation for me, my mentor and collaborators. We’re each only given one life, and I’m determined to give back as much as I can to society through science.”

Four talented early-career researchers were awarded prestigious Fishman Fund Awards.

When Dr. William and Lillian Fishman founded our Institute in 1976, they knew that nurturing the next generation of scientists was just as important as advancing cutting-edge research. Today, their values live on in the form of the Fishman Fund Awards, which help exceptional postdoctoral researchers develop into scientific leaders.

On September 24, four talented early-career researchers received the prestigious award during an inspiring virtual ceremony. Generous benefactors, past award winners, and family and friends tuned into the event, which featured remarks from Institute president Kristiina Vuori, MD, PhD; professor and Fishman Fund Award recipient José Luis Millán, PhD; Fishman Fund co-founder Reena Horowitz and co-founder designee Jeanne Jones.

“The Fishmans firmly believed in helping brilliant early-career postdoctoral scientists become great principal investigators,” says Ms. Horowitz, who established the Fishman Fund Awards in 2001 with her late friend Mary Bradley. “Our goal with these awards is to encourage and support these researchers in their quest for the next great medical breakthroughs, which might one day be able to save the lives of our family members, friends and neighbors.”

Fishman Fund winners undergo a rigorous selection process that includes a personal interview and a presentation to the selection committee. All winners receive a $10,000 career development award that can be used to attend workshops, network and travel to national and international conferences to learn about the latest developments in their research fields. The winner of the Fishman Fund Fellowship receives a two-year salary stipend in addition to the professional development funding.

Meet this year’s Fishman Fund Award winners

Fishman Fund Fellowship Award

Kyungsoo Shin, PhD, grew up in Halifax, Nova Scotia, in Canada, where he also attended Dalhousie University for his undergraduate and graduate studies. Dr. Shin works in the laboratory of Dr. Francesca Marassi, where he is advancing a potential treatment for age-related macular degeneration, a leading cause of vision loss in people over the age of 60. Dr. Shin recently showed that a protein called vitronectin is the likely cause of the pebble-like deposits in the back of the eye that underlie the disease. With this information, scientists can now work toward a treatment to prevent vision loss.

Dr. Shin’s career goal is to become an independent researcher focused on understanding how cellular membranes—gatekeepers that regulate what enters or exits a cell—are involved in disease. He hopes to mentor and inspire the next generation of scientists to advance our understanding of human biology.
 

Fishman Fund Career Development Awards

Marie Berenguer, PhD, grew up near Paris and went to school in Bordeaux. She is currently studying in the laboratory of Dr. Gregg Duester and focuses on how a compound called retinoic acid affects the way embryos are formed. Her work may open new avenues to prevent and treat birth defects.

Dr. Berenguer’s career goal is to become a principal investigator and lecturer in genetics and developmental biology. By leading her own research team, she hopes to improve our understanding of genetic diseases and lay the foundation for future therapies.

Daniela Dengler, PhD, is from Germany, where she studied pharmacy and worked in a pharmacy for a year before she decided to pursue her PhD at the Friedrich-Alexander University in Erlangen-Nuremberg, Germany. Dr. Dengler works in the Conrad Prebys Center for Chemical Genomics with Dr. Eduard Sergienko. She is searching for new drugs that bind to proteins called G-protein coupled receptors (GPCRs), which mediate many physiological processes in the body. More than 30% of all FDA-approved drugs act on GPCRs.

Dr. Dengler’s career goal is to become a project leader in biotech, where she wants to combine her background in chemistry with her knowledge in assay development and high-throughput screening to find drugs for unmet medical needs.

Chiara Nicoletti, PhD, grew up in Gela, in Sicily, and received her PhD at the University of Padua in northern Italy. Dr. Nicletti is in Dr. Pier Lorenzo Puri’s lab and is studying the links between genetic sequences and risk of disease. Her research will open new avenues to help clinicians practice personalized medicine—including predicting who is likely to get a disease, how to prevent it, how to treat it and perhaps even cure the condition.

Dr. Nicoletti’s career goal is to become a principal investigator, leading her own research team that focuses on integrating foundational research with everyday medical practice to improve human health.

Watch the Fishman Fund Awards ceremony, which featured remarks from Institute president Kristiina Vuori, MD, PhD; professor and Fishman Fund Award recipient José Luis Millán, PhD; Fishman Fund co-founder Reena Horowitz and co-founder designee Jeanne Jones.

Learn more about the Fishman Fund, or, donate now, to support future scientific leaders.

Kyungsoo Shin is the winner of this year’s prestigious Fishman Fund Fellowship Award, which helps talented early-career researchers become scientific leaders

While growing up, Kyungsoo Shin always found himself drawn to science. Learning how the body works was endlessly fascinating to him. But it wasn’t until he was in the middle of his PhD that he became officially hooked on research.

“I was doing a long 16-hour experiment, and around 9 or 10 p.m. I started getting really positive results. I was so excited that I called my supervisors at the time,” recalls Shin. “Even though it was so late, they were just as happy as I was! That was my first introduction to how intoxicating research can be, and the power of a supportive community.”

Today, as a postdoctoral researcher at Sanford Burnham Prebys, Shin is applying his passion for discovery to an area of great need: finding a treatment for dry age-related macular degeneration (AMD). No treatments currently exist for the common condition, which is the main cause of vision loss for people over the age of 60. As a new father, this research became especially meaningful to Shin.

“My son is 3 months old, and just started to smile and laugh,” says Shin. “I couldn’t imagine one day not being able to see him, or my grandchildren. If I had dry AMD, I probably wouldn’t be able to even drive to go see him. I don’t want to imagine that sort of life for anyone.”

Working with a world-renowned scientist

Shin has found a wise mentor in Professor Francesca Marassi, PhD, one of the world’s leading experts on nuclear magnetic resonance (NMR) spectroscopy. This technology allows scientists to see the shape of a protein, which enables rational drug design. When the job posting first appeared, Shin was writing his PhD thesis—but his supervisor told him to stop writing and apply to the position immediately. The opportunity to work with Marassi was too important.

“Learning from her has fundamentally changed who I am as a scientist,” says Shin. “Before I used to think in terms of completing projects. Now I ‘follow the science,’ which means let the data lead me to my next step.”

This approach has proved successful: Marassi and Shin recently uncovered a new drug target for dry AMD. Using NMR and other cutting-edge technologies located at the Institute, they deciphered the shape of a protein called vitronectin. Then they showed that the sticky, propeller-shaped protein likely “seeds” the formation of pebble-like structures in the back of the eye that cause vision loss.

Fishman Fund Award advances key research

Now, with the support of the Fishman Fund Fellowship Award—which provides a salary stipend and $10,000 for career development—Shin can attend scientific conferences that will help him think outside of the box and grow as a scientist. Receiving an award in honor of the Fishmans—who started the Institute after reaching mandatory retirement age—is special to Shin.

“The Fishmans were so devoted to pushing our understanding of human health that they continued their research even when they didn’t have to,” says Shin. “To receive a fellowship that is named after such inspirational and honorable people is truly an honor. I have a great sense of responsibility to advance research that will have a positive impact on humanity, and could one day benefit my son or his children.”

Sanford Burnham Prebys is grateful to the generous Fishman Fund donors who make the career development awards possible. Learn more about the Fishman Fund, or donate now, to support future scientific leaders.