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Usue Etxaniz Irigoien awarded Fishman Fund Fellowship

AuthorSusan Gammon
Date

June 13, 2018

Congratulations to SBP postdoc Usue Etxaniz Irigoien, PhD—the recipient of the 2018 Fishman Fund Fellowship. This prestigious award is a “super stipend” given to exceptional young researchers in recognition of their research accomplishments and in support of their future research plans. Etxaniz Irigoien will use the financial support to continue her research on muscle biology—explorations that may lead to treatments for disorders such as muscular dystrophy and amyotrophic lateral sclerosis (ALS).

“I’m honored to receive this special fellowship,” says Etxaniz Irigoien. “I came to SBP to pursue my interest in muscle development and regeneration, and have been so fortunate to work with world-renowned, collaborative scientists with similar interests. This award makes the whole experience even better, and secures my ability to continue making discoveries that may one day improve human health.”

Etxaniz Irigoien, a postdoc in the laboratory of Pier Lorenzo Puri, MD, PhD, professor in the Development, Aging and Regeneration Program at SBP, studies a type of muscle cell called fibro-adipogenic progenitors, or FAPs. These are the cells that act as intramuscular sensors and effectors, which means that FAPs can detect “alert” signals and generate different responses by orchestrating other cells’ activity upon different muscle perturbations. In healthy conditions, when muscle suffers an injury, FAPs cue muscle stem cells to repair the damaged muscle fibers. However, in disease (i.e., muscular dystrophies or neuromuscular disorders such as ALS), FAPs’ activity results in fibrosis, fat deposits and other detrimental events that contribute to disease progression.

“If we can begin to uncover how FAPs support muscle regeneration, or contribute to muscle degeneration in different environments, i.e., healthy versus disease tissue, we can look for potential therapeutics that will move the process toward the healthy state,” says Etxaniz Irigoien. “This is so important because today there are no effective therapeutics for dystrophies or ALS, and it’s time we make progress to help these patients.”

Etxaniz Irigoien has come a long way from her hometown of Getaria, a small fishing village located in the Basque Country of Northern Spain. She says, “I had a biology teacher who inspired my interest in science, and I have always known I wanted a career in research. My family, most of whom still live in Getaria, are very supportive and excited about my career and this award. In fact, some of them will be traveling to San Diego for the Fishman Fund ceremony in September. I’m very excited for them to visit SBP and meet some of my colleagues.”

Getaria, located in the Basque Country of Northern Spain
Getaria, located in the Basque Country of Northern Spain
 
Usue as young girl in Getaria
Usue as young girl in Getaria

The Fishman Fund Fellowship
The Fishman Fund Fellowship was established in honor of Dr. William and Mrs. Lillian Fishman, co-founders of SBP. Applicants must have a doctoral degree, no more than five years of training at any institution, and at least one full year of postdoctoral study at SBP. Fellowship support is for two years in length and covers salary, benefits and a professional-development allowance.

SBP is thankful for the generous Fishman Fund donors who make career development awards possible. If you would like to donate to the Fishman Fund to support young scientists click here.

Institute News

2017 Fishman Fund Award Ceremony celebrates postdoctoral scholars

AuthorHelen I. Hwang
Date

September 20, 2017

More than 100 supporters of Sanford Burnham Prebys (SBP) Fishman Fund Awards came out to honor this year’s Fishman Fund Award recipients: David Sala Cano, PhD, Michael J. Stec, PhD, and Jose Luis Nieto Torres, PhD, at the Sanford Consortium on Tuesday evening.

Malin Burnham, SBP’s Honorary Board Trustee, spoke about SBP exemplifying collaboration as part of its DNA. He also said that of all the organizations he works with, he gets the most satisfaction from being involved with SBP. Dr. Torres received the award and Fishman Fund medallion from Burnham, while Torres’ parents watched on with pride. They flew in from Spain, visiting the United States for the first time.

Fishman Fund co-founders and SBP supporters Reena Horowitz and Jeanne Jones led the ceremonies as they spoke about the founding of the Fishman Fund Award in 2001. The Fishman Fund Career Development Awards have grown from a $1,500 allowance to $10,000 stipends for each recipient so they can attend workshops, network and travel to national and international scientific conferences to learn about the latest developments in their research fields. The generosity of Fishman Fund donors enables such important career advancement opportunities for future scientific leaders.

Greg Lucier, former SBP board member and CEO of NuVasive, Inc., also spoke on the topic of “we versus me,” emphasizing the importance of teamwork. SBP supporters Dr. Andrew Viterbi, co-founder of Qualcomm, and Armi Williams, Fishman Fund Advisory Board member and former SBP trustee, presented Fishman Fund awards and medallions to Drs. Stec and Cano, respectively.

This year’s recipients gave short presentations on their work, each of which dealt with aging, including muscle stem cells, muscle regeneration and autophagy (body’s ability to eliminate waste and recycle). Read more about their work below.

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2017 Fishman Fund Awardees:

David Sala Cano, PhD, a postdoctoral scholar in the laboratory of Alessandra Sacco, PhD, is working on muscle stem cells. He focuses on muscle wasting, a major health problem that leads to poor quality to life, and is associated diseases such as diabetes, chronic kidney disease, cancer and aging. He is working on identifying new targets for drugs that may prevent skeletal muscle degeneration.

Dr. Cano comes to La Jolla from a small town of Abrúcies, Spain. He holds degrees from the University of Barcelona, including a BS degree in biochemistry, a MS degree in physiology and a PhD in biomedicine. His goal is to become a principal investigator in an academic setting, combining his passion for research and teaching.

Michael J. Stec, PhD, focuses on understanding the mechanisms regulating stem cell function and skeletal muscle regeneration; he is also in the laboratory of Alessandra Sacco, Ph.D. He aims to develop novel therapies for improving muscle function in aged and diseased individuals.

Dr. Stec hails from Whippany, New Jersey. He holds a BS degree in health and exercise science from the College of New Jersey, a MS degree in exercise science from Bloomsburg University of Pennsylvania and a PhD in pathobiology and molecular medicine from the University of Alabama in Birmingham. Ultimately, his career goal is to obtain a position in the biotech industry.

Jose Luis Nieto Torres, PhD, is a postdoctoral scholar in the laboratory of Malene Hansen, PhD He conducts research on autophagy—a process our bodies use to eliminate cell waste by recycling debris into usable sources of energy. Our bodies need to be able to eliminate debris that accumulates over time and make new components for proper functioning. Autophagy declines with aging, and is associated with many age-related diseases.

Dr. Torres joined SBP from Palencia, Spain. He obtained his BS degree in biochemistry and biology from the University of Salamanca and MS and PhD degrees in molecular biology from the Universidad Autonoma de Madrid. In the future, Dr. Torres aims to become a principal investigator of his own lab in an academic setting.

 

 

 

 

 

 

Institute News

SBP supporters Dr. Tom and Cindy Goodman host SBP’s postdocs for the holidays

AuthorHelen I. Hwang
Date

December 9, 2016

For the last ten years, Cindy and Dr. Tom Goodman have a tradition of inviting Fishman Fund winners, past and present, for a holiday celebration. “It’s a delight to see everyone in a social setting – listening, learning and sharing.” Conversations range from the latest and greatest on melanoma research to cultural discussions about what Thanksgiving is about.

The Goodmans have been supporters of Sanford Burnham Prebys Medical Discovery Institute (SBP) and the Fishman Fund for the last decade or so. Every year, they’ve invited the winners of the Fishman Fund to their own home to share a holiday dinner. Cindy Goodman’s family always had a tradition of having students over for big meals when she was growing up in Ohio. She wanted to continue the tradition here with SBP’s community.

The Fishman Fund provides funding for exceptional postdoctoral researchers with a Fishman Fund Fellowship and Fishman Fund Career Development Awards. Founded in 2001, the Fishman Fund was established by SBP supporters Mary Bradley and Reena Horowitz, to honor the Fishmans. In 2010, Jeanne Jones became the co-founder designee. SBP introduced the Fishman Fund Awards in honor of the Institute’s founders, Dr. William and Lillian Fishman. So far, the Fishman Fund has funded over 55 postdoctoral researchers.

Recently, the families of four Fishman Fund recipients went to the Goodmans’ home to share Thanksgiving dinner. Fishman Fund awardees Stefan Grotegut, Melanie Hoefer, Petrus de Jong, Bernhard Lechtenberg and Jia (Zack) Shen all enjoyed a holiday celebration with the Goodmans. Former Fishman Fund winner Karthik Bodhinathan also called from the Boston area, where he now works for a pharmaceutical company, after spending six holidays with the Goodmans.  In fact, they’ve grown so close that they met Bodhinathan’s sister on a trip to Singapore.

The appreciation we feel “magnifies in unexpected ways,” says Cindy. This year, there were 16 people in their home, including children, ranging from age 1 to 8 years old. The Goodmans made turkey, potatoes and cranberry sauce for some guests who’ve never enjoyed such a feast before.

For Shen and his family, it was their first American Thanksgiving and he wasn’t quite sure what to expect. “We really enjoyed the fantastic Thanksgiving dinner at Cindy and Tom’s home. The house was so cozy. Cindy and Tom just treated us like family members. During the dinner, we talked about life in San Diego, my plans for the near future and the funny things about my baby Olivia. Also, we had nice conversations with the other winners’ families. And all of us gave our thanks to Goodman family. It was a wonderful evening!”

“I would be delighted if others opened their houses and hearts to one student or family,” says Cindy Goodman. Their experiences have been so delightful that she hopes someone else will also gain from the gift of sharing as the Goodmans have benefitted for the last decade.

For more information about the Fishman Fund, click here.

Institute News

Meet the 2016 Fishman Fund awardees

AuthorHelen I. Hwang
Date

September 16, 2016

When Joana Borlido, PhD, got the call that she won the inaugural Fishman Fund Fellowship late on a Friday afternoon, she called her parents, who had been waiting up past midnight in her native Portugal to find out if she had won the prestigious two-year postdoctoral fellowship along with a $5,000 career-development cash grant.

After all, her mother, a science teacher, had inspired Borlido to go into science by bringing home props of human body parts and subscribing to an immunology comic series. Yes, those biology cartoons do exist.

On September 15, the Fishman Fund ceremony honored Borlido and Fishman Fund Career Development recipients Bernhard Lechtenberg, PhD, and Jia (Zack) Shen, PhD

In celebration of SBP’s 40th anniversary, the significance of the Fishman Fund has been elevated with the addition of a two-year postdoctoral award called the Fishman Fund Fellowship. The Fishman Fund Fellowship is an incredible award that not only compensates exceptional postdocs at a higher income level than a typical fellowship, but also comes with a one-time $5,000 flexible career-development award, which they can use to further their professional endeavors. The established Fishman Fund Career Development awards of $10,000 will continue to be awarded as well.

Since the Fishman Fund’s inception in 2001, the Fishman Fund has grown from $1,500 cash awards. It was first established by Horowitz and Mary Bradley in honor of founders Dr. William and Lillian Fishman. In 2010, Jeanne Jones became the co-founder designee.

During the ceremony, Fishman Fund co-founder Reena Horowitz discussed the importance of supporting “the next generation of biomedical trailblazers.” She also said that the “Fishmans believed passionately in cultivating early-stage scientific talent. They knew that young investigators must focus intently on honing research skills and gaining professional experience.” Horowitz also took a moment to honor friends and supporters who have passed: Mary Bradley, Erna Viterbi, Pauline Foster, and Conrad Prebys.

Nina Fishman, daughter of SBP founders Dr. William and Lillian Fishman, read from a speech her father gave at the Institute. He said, “Each is encouraged to develop original ideas, which can be tested experimentally and subsequently qualify for grant support. Together we have the ‘critical mass’ of intellectuals and skills to accelerate progress in sciences.” She added that the Institute has demonstrated that a “relatively small but highly focused group can provide a nucleus where the whole is greater than the sum of its parts.”

Past winner Petrus de Jong, MD, PhD, shared how the Fishman Fund has boosted his career. With the grant, de Jong attended a drug delivery systems symposium with biotech entrepreneurs, participated in a research symposium in pancreatic cancer and received tailored career advice from senior scientists. “These events have been crucial for my personal career development, which would not have been possible without the Fishman Fund Award,” he said.

Fishman Fund Fellowship Awardee:

Joana Borlido, PhD, explores the mechanisms through which the channels that connect the cell nucleus (where the genome is stored) affect the immune system. She works in the laboratory of Maximiliano D’Angelo, PhDHer work will help elucidate the molecular basis for the onset and development of leukemia.

She completed her PhD in Oncology at the University of Cambridge in the U.K. and her BS in Biology at the University of Porto in Portugal.

If Borlido is not in the lab, she can usually be found playing foosball, which she admits she would play during all her free time if she could.

Fishman Fund Career Development Recipients:

Bernhard Lechtenberg, PhD, studies cellular signaling networks in normal human physiology and diseases in the laboratory of Stefan Riedl, PhDLechtenberg uses protein X-ray crystallography to study diseases such as cancer and ALS (Lou Gehrig’s disease). He received his BS and MS from the University of Luebeck in Germany and his PhD from the University of Cambridge in the U.K.

In his spare time, he and his wife Anne Hempel, also a SBP postdoc, participate in Ragnar Relay races, in which a team runs nonstop day and night to complete a course of almost 200 miles.

Jia (Zack) Shen, PhD, develops functional screens of for drugs that inhibit ubiquitin ligases (enzymes that tag proteins with a small protein called ubiquitin). Such drugs, alone and in combination with current chemotherapies, are considered important advances in the therapy of breast cancer patients. Shen works in the laboratory of Charles Spruck, PhD, and received his BS from Zhejiang Sci-Tech University and his PhD from the Chinese Academy of Sciences.

He and his wife love taking their 6-month-old daughter Olivia for walks in San Diego. Shen also plays soccer twice a week with a team at the Salk Institute.

With the generous support of the Fishman Fund, this stellar group of postdocs will benefit tremendously from well-earned rewards for their hard work and vision for “Science Benefiting Patients.”

Institute News

2015 Fishman Fund Award recipients honored

Authorsgammon
Date

October 5, 2015

The 2015 Fishman Fund Award recipients were honored at an October 1 gathering of Sanford Burnham Prebys (SBP) supporters that celebrated the enduring legacy of the Institute’s founders, Dr. William and Lillian Fishman.

Continue reading “2015 Fishman Fund Award recipients honored”