Guy Salvesen Archives - Sanford Burnham Prebys
Institute News

A path to parity for Black PhD students in the sciences

AuthorMonica May
Date

August 18, 2020

Graduate school dean Guy Salvesen describes barriers he has seen for students who are Black and how we can make science fully inclusive.

Only 5% of graduate students in science and engineering are Black despite making up more than 13% of the U.S. population—and in spite of showing similar levels of interest in science as their peers. A PhD is required for career advancement in biomedical research—so this disparity impacts the number of faculty members, CEOs and scientific leaders who are Black. It will take persistent and bold efforts on the part of individuals, groups, institutions and society at large if we are to achieve anything close to equality.

To learn more about this topic, we spoke with Guy Salvesen, PhD, professor and dean of the Graduate School of Biomedical Sciences at Sanford Burnham Prebys about barriers that discourage students who are Black from applying to PhD programs—and how they can be dismantled to address disparities.

Why are you personally passionate about achieving racial equality in the biomedical sciences?
Standing up for equality has always been a big part of my family’s values. I was born in South Africa during the era of apartheid. My mother always made it clear that she detested racism and the people who defended it. Before we moved away, she was part of a resistance organization called the Black Sash—a woman’s-only movement against apartheid. I come from a single-parent household, so my mother had an especially big influence on me.

Do you receive a lot of applications from PhD students who are Black?
We receive many applications from Latinx students, but I have to say not as many from Black students. We know this is not due to lack of interest. There are systemic barriers at play, which as a graduate school we try to address to the best of our abilities. Our founding mission was to have a student population that mirrors California’s demographics, so we are committed to doing all we can to reach that goal.

Guy Salvesen, PhD, dean, Graduate School of Biomedical Sciences

Guy Salvesen, PhD, is the dean of the Graduate School of Biomedical Sciences at Sanford Burnham Prebys.

In your experience, what are the barriers that prevent students who are Black from applying to PhD programs?
First, I believe the biggest hurdle is the monetary aspect of a career in science. The field is poorly rewarded financially, especially compared to a career such as pharmacy or medicine. You must commit to almost a decade of minimum-wage pay as you complete graduate-school and then postdoctoral studies. Scientists are some of the most highly trained individuals in the world—and for many years, they are paid close to minimum wage.

Even when you complete training and find a well-paying job, many students have educational loans to pay back—and Black students are more likely to have loans because of the racial wealth gap. The students who apply but don’t attend our graduate school typically accept positions in pharmacy, where they can more rapidly start earning a high salary. To pursue biomedical research as a career, you have to be incredibly passionate about science and be able to defer economic rewards. I wish it wasn’t like that, but that’s the reality.

I believe it’s important to get students excited about science early and sustain that enthusiasm. Once a student begins a PhD program, they are hooked. We need to make sure that kids who are Black are getting early, positive experiences with science. This can be accomplished through school or after-school programs. This also helps children see themselves as scientists—and that’s an incredibly important factor as students consider their future careers.

What solutions could overcome these barriers?
Ideally, the National Institutes of Health would allocate funds to pay graduate students and postdocs better wages. This is also an area where philanthropy can play a big role. At Sanford Burnham Prebys, we are always grateful to the Fishman Fund Awards, which supplement the salaries of select postdocs. In a perfect world, we would be able to pay better wages to all graduate students and postdocs. Also, any actions that decrease student loan debt would help free students to choose science as a viable career option.

We need to ensure that we are proactively reaching out to schools that are serving students who are Black, especially Historically Black Colleges and Universities which award up to 30% of Black STEM PhDs; providing a safe and welcoming environment for graduate students who are Black; educating our Institute and especially faculty mentors about how to best support students from different racial backgrounds; and hiring faculty members who are Black. We also need to continue to listen and learn about additional actions we can take to achieve racial parity in our program.

Could you share some examples of actions the graduate school took that had particular success?
A partnership we have with the Preuss School, a middle and high school for students who would become the first in their families to graduate from college, has been very successful. Preuss students spend time in our Institute’s labs during the summer and experience what it’s like to work side by side with scientists. We also try to bring parents into the mix by inviting them to our campus, because they have a tremendous influence on the careers their children pursue. Many of our Preuss students went on to select STEM majors in college. Right now, we are short on funds to continue this program. We need support to keep it going.

We also liaise with California state colleges that serve members of underrepresented groups, such as the California State University campuses in Fresno, Long Beach and nearby San Marcos. Through summer internship programs, students from these schools experience advanced laboratory research for the first time. Once these students realize how much fun it is do science in a state-of-the-art facility, they get very excited.

Where do we go from here? Are you hopeful about the future?
It gives me hope that there is movement in society to redress wrongs that have occurred for more than 400 years. I’m optimistic that societal pressures will translate to real action. These issues are not new. It’s time that we listen, learn and take action. And that’s on all of us. No one is immune from systemic racism, and each of us has a role we can play to make positive change.

If you have any questions, comments or would like to share follow-up resources, contact us at info@sbpdiscovery.org.

Dr. Salvesen’s suggested readings:

Institute News

Cell Suicide: Caspases Call the Shots

AuthorSusan Gammon
Date

July 28, 2017

People are usually surprised to learn that many cells in our bodies essentially commit suicide. These cells don’t die because they are sick, but because they are following built-in signals that initiate their death. 

A few examples illustrate how this regulated cell death is really not surprising at all, but in fact is essential for proper development and health: 

  •  Developing fetuses generate many more cells than they can use. Excess cells that don’t contribute effectively to developing tissues must be eliminated to avoid accumulation of non-functional cells. 
  •  Many adult tissues contain cells that proliferate rapidly to replace old, worn-out cells. Without elimination of the old cells, tissues would balloon up  with non-functional cells. Adults may lose more than 50 billion cells every day due to this cell replacement process. 
  • Abnormal cells need to be eliminated to avoid development of diseases like cancer. The loss of ability to undergo regulated cell death is one  hallmark of malignant cancer cells.

What really is surprising about regulated cell death is the number of different ways cells can terminate themselves. This suggests that the different cell death pathways must communicate with each other to decide which mechanism will be used in a given situation. 

In a commentary in Cell Chemical Biology, Guy Salvesen, PhD, professor at  SBP reviews a recent report that partly solves the riddle of communication between two of these cell death pathways, called apoptosis and pyroptosis. 

Salvesen explains, “Apoptosis and pyroptosis are similar in that they both rely on protein-cleaving enzymes called caspases to carry out the cell death sentence. But there are big differences. Pyroptosis is a messy death that releases a lot of cell debris, activates the immune system and triggers inflammation. It does this via caspase-1, a version of the enzyme that chops up a protein called gasdermin-D (GSDMD) to create a small toxic piece of GSMD that mediates the process.  

“In contrast, apoptosis uses caspase-3 and caspase-7 to initiate cell death by damaging the cell nucleus and its DNA, causing a relative quiet cell death with minimal disruption to the rest of the body. These caspases also cleave GSDMD, but in way that doesn’t create the toxic fragment. Apoptosis is dominant—so once it’s triggered pyroptosis is put on the back burner.”

First author Marcin Poreba, PhD, a postdoc in the Salvesen lab, adds that, “The decision of a cell to use pyroptosis versus apoptosis depends to a large extent on the strength of the death signals the cell receives. In most cases, apoptosis will win out because of its ability to block the pyroptosis process. This is a good thing, since regulated cell death usually occurs as part of normal development and maintenance programs in which inflammation should be avoided. But in cases where pyroptotic stimuli are strong enough, for example in response to the need to eliminate cells infected by bacteria or viruses, the pyroptotic pathway can override apoptosis and terminate cells in a way that also recruits the immune system into the battle. It’s almost like a contest to see which caspases win the death race. 

Read the paper here.

Institute News

Leukemia research breakthrough: a new way to trigger cancer cell suicide

AuthorJessica Moore
Date

May 18, 2016

Better therapies for acute myeloid leukemia (AML), a fast-growing cancer of the bone marrow, are urgently needed. Nearly 15,000 people in the United States are diagnosed with AML each year, and it’s the most common acute leukemia in adults. The cause of the disease is unknown, and it is usually fatal within the first five years. Continue reading “Leukemia research breakthrough: a new way to trigger cancer cell suicide”

Institute News

Postdoc Symposium 2015

Authorsbraun
Date

September 10, 2015

On September 2, Sanford Burnham Prebys Medical Discovery Institute (SBP) held an inaugural Postdoc Symposium to showcase the critical contributions made by 126 SBP postdoctoral students to advance the Institute’s discovery science and heightened commitment to translational research.

Continue reading “Postdoc Symposium 2015”

Institute News

SBP Graduate School of Biomedical Sciences receives WASC accreditation

Authorsgammon
Date

July 30, 2015

Sanford Burnham Prebys Medical Discovery Institute (SBP)  is proud to announce that its Graduate School of Biomedical Sciences has received accreditation by the Western Association of Schools and Colleges (WASC). This is an important milestone for the Graduate School, a distinction that assures the public that our school has the resources, policies, and practices in place to achieve its educational goals.

The SBP Graduate Program began in 2006. Today, we have 25 students with a unique opportunity to carry out their studies in an environment of collaborative research, with access to the most-sophisticated minds and technologies in biomedical sciences. The Program gives graduate students fluency in biology, chemistry, bioinformatics, and engineering to integrate research into meaningful applications that will advance medicine. Their education comes at a time when research has never been more intellectually exciting and critically important to society.

The effort was led by Guy Salvesen, PhD, dean of the Graduate School, who has been dedicated to providing the best learning opportunities for SBP students to become the next-generation of pioneers in biomedical research. Dr. Salveson has overseen the recruitment of talented students from around the world—Europe, Asia, Australia and the United States—and engaged our faculty to teach, train and mentor. He has been accountable to WASC during an eight year systematic process of scrutiny that left no stone unturned. At the same time, he has managed his own research laboratory of staff scientists, postdocs, graduate students and interns, exploring the principles of proteolysis in humans.

In addition to Dr. Salveson, Malene Hansen, PhD, associate dean of Student Affairs; Alessandra Sacco, PhD, associate dean of Curriculum; Robert Rickert, PhD, associate dean of Admissions, and Stacey Smith, manager of the Graduate Program, have helped achieve the goal through their passion for education, and creating an environment that supports the highest-quality learning in biomedical research.

Many congratulations to everyone at SBP that works to support the Graduate School, including the faculty, staff, and the students, for creating and fostering a program that is now officially recognized for its excellence.

Institute News

We know what the scientists of the future did this summer

Authorsbraun
Date

July 22, 2015

On July 17, 11 students from The Preuss School UCSD celebrated the end of an intensive two-week summer research program with a poster symposium and luncheon at SBP’s La Jolla campus. The program provided talented 11th graders with the opportunity to experience what it is like in a research lab, learning daily research lessons and laboratory experiments, and about the various careers in science. Continue reading “We know what the scientists of the future did this summer”

Institute News

How arsenic cures leukemia

Authorsgammon
Date

June 18, 2015

For the first time, Sanford-Burnham researchers have shown how the reversible interactions of the small protein SUMO work to facilitate treatment of acute promyelocytic leukemia (APL). The study, published recently in the journal Science Signaling, explains how the on-off associations of SUMO are required to destroy the APL causing oncoprotein and pave the way for an arsenic-based cure. Continue reading “How arsenic cures leukemia”

Institute News

Highlights from the Graduate School of Biomedical Sciences annual retreat

Authorsgammon
Date

May 27, 2015

On May 13-18, Sanford-Burnham’s Graduate School of Biomedical Sciences held its sixth annual retreat in San Marcos, Calif.

This year’s theme, “Effectively Communicating Scientific Research to a Broad Audience,” gave the students an opportunity to share their research and practice explaining their work in simple terms—simple enough for non-scientists.

Organized by Francesca Boscolo Sesillo, Mirco Guigli, and Gianluigi Lichinchi, all graduate students at the Institute, the presenters were encouraged to address questions such as:

  • Why the research is important
  • How will it advance our understanding of the subject matter
  • Will the research impact human health

As a very grateful invited guest, I was dazzled by the presentations. Many of the students included analogies and graphics that made some very complex information—structured illumination resolution, haploinsuffient photoreceptors, SWI/SNF BRAHMA chromatin remodeling, just to name a few—clear enough for this “arm-chair” scientist to be dangerous.

 

For many reasons, effectively communicating science to non-scientists and scientists within other disciplines is critical. Like it or not, when you explain science you are selling. You may be selling your ideas to seek funding and grants, convincing others of your findings, or recruiting people to work on your project.

The students took it seriously, not only because many of their mentors and advisors were in the audience, but also because they were scored on a scale of 1-5 for quality, content, and clarity of the presentations. When the score cards were tallied the winner was… (drum roll, please)

Francesca Boscolo Sesillo (Sacco Lab)

Francesca, a third year student, presented her research on the role of p21 during skeletal muscle regeneration. Her findings show that p21, a cell cycle inhibitor, plays a key role in the activation and differentiation of muscle stem cells.  Understanding the mechanisms that lead to muscle regeneration has important implications for future interventions that can improve muscle health in the elderly as well people with degenerative disorders such as muscular dystrophy.

 

Many congratulations to all the fabulous students, and to Guy Salvesen, Ph.D., Dean of the Graduate School, for providing leadership and education opportunities for the students.

And a special thanks to:

  • Fiona Scott, PhD, Associate Director of Biology at Receptos, who shared her professional experience as scientist in clinical research.
  • Thomas Baldwin, PhD, Dean of Natural and Agricultural Sciences at UC Riverside for contributing to the communication training provided to the students.
  • America Vega and Stacy Smith for organizing the retreat.
  • And to Pfizer, Genentech, and Receptos, for underwriting the event.

 

 

 

Institute News

Targeting protein could improve diagnosis and treatment of lymphoma

AuthorGuest Blogger
Date

January 26, 2015

This post was written by Janelle Weaver, PhD, a freelance writer

Lymphoma is the most common blood cancer in the United States and is responsible for about 20,000 deaths each year. This type of cancer begins in white blood cells called lymphocytes, which normally play an important role in the immune system by recognizing and responding to pathogens such as bacteria and viruses. To control infections, these cells must multiply in a process that depends on a protein called MALT1. But when inappropriately activated, MALT1 drives the survival of lymphoma cells, underscoring the need to monitor the activity of this protein to develop novel diagnostic tests and facilitate drug discovery. Continue reading “Targeting protein could improve diagnosis and treatment of lymphoma”