john sedy Archives - Sanford Burnham Prebys
Institute News

How our immune system controls gut microbes

AuthorMiles Martin
Date

April 6, 2022

And how this relationship could help fight autoimmune diseases

Sanford Burnham Prebys researchers including Carl Ware, PhD, and John Šedý, PhD have discovered an immunological process in the gut that could help improve treatment for autoimmune and gastrointestinal diseases. The study, published March 22 in Cell Reports, found that this process regulates the activation of white blood cells in the intestines, which ultimately helps the body control the composition of the gut microbiome. 

“The immune system is like a gardener for our gut bacteria, gently monitoring and responding to their populations and keeping an eye out for unwanted pathogens” says Ware, who directs the Infectious and Inflammatory Diseases Center at Sanford Burnham Prebys. “This ultimately helps the immune system control these microbes.”

This “gardening” relies on a molecule called BTLA, one of several checkpoint proteins used by the body to control the immune system. 

“This is a signaling system we’ve known about for decades, but this is a totally new function for it that we’ve never seen before,” says Šedý, a Sanford Burnham Prebys research assistant professor, who co-led the study with Ware. “I helped discover this system two decades ago, so it’s exciting that we’re still making new discoveries about its function.”  

To explore the role of BTLA in the gut, the team zeroed in on specialized lymph nodes in the intestines called Peyer’s patches, which are full of white blood cells that help monitor and respond to pathogens and other microbes in the gut.

“Gut bacteria are in constant competition, and the populations of specific species can fluctuate,” says Ware. “In a healthy microbiome, there’s a balance, and disrupting that balance can contribute to autoimmune diseases, gastrointestinal disorders and even some brain disorders.”

The team found that BTLA is critical for maintaining this balance because it triggers white blood cells to release antibodies that control the populations of different gut bacteria.

“It’s a finely calibrated system that we’re still only just beginning to understand in detail,” adds Ware.

Immune checkpoints like BTLA are already used in immunotherapy for some cancers, and these results make the researchers confident that this system can be leveraged to treat diseases in the gut, especially those that are also autoimmune disorders, such as Crohn’s disease or ulcerative colitis. 

“The immune system is unimaginably complex, and understanding it gives us the ability to manipulate it, and that can help us treat diseases,” says Šedý. “This discovery is a step forward in that larger narrative.” 

Institute News

You’re invited to a psoriasis research update and reception

Authormigartua
Date

December 15, 2015

Come join us at Sanford Burnham Prebys Medical Discovery Institute (SBP) to learn about the latest research in psoriasis and psoriatic arthritis taking place in your community. The Psoriasis Research Update and Reception is jointly sponsored by SBP and the National Psoriasis Foundation. The event will take place on:

Tuesday, February 2, 2016 6:00 – 8:00 p.m. Sanford Burnham Prebys Medical Discovery Institute Building 12 Auditorium 10905 Road to the Cure San Diego, CA 92121

Take a tour of the SBP Psoriasis Research Lab and come to the reception where we will provide hors d’oeuvres and beverages.

 

Our guest speakers will include:

  • Carl Ware, PhD, Director of SBP’s Infectious and Inflammatory Diseases Center
  • John Sedy, PhD, Research Assistant Professor
  • Randy Beranek, President and CEO of the National Psoriasis Foundation
  • Erik Gilbertson, MD, Division Head of Dermatology at Scripps Clinic

RSVP to hbuthmann@sbpdiscovery.org by January 29, 2015 to reserve your spot.

 

We look forward to seeing you there!

Institute News

Will your autoimmune disease be cured?

Authorsgammon
Date

August 25, 2015

More than 23 million Americans have an autoimmune disease. And although there are more than 80 different types of autoimmune diseases, they all have three things in common:

  1. The immune system is attacking healthy cells
  2. The cause of the disease is unknown
  3. There is no cure

No cure. No cure. No cure. That’s not good news. Given that I have a 1 in 12 chance of getting an autoimmune disease in my lifetime (if you are a man your chance is 1 in 20), and those chances increase with every birthday (and mine is next month), I asked SBP experts in immunology what makes them hopeful that we are on the road to better treatments for these chronic, debilitating, and sometimes deadly diseases. Below are their forward-looking answers.

 

Continue reading “Will your autoimmune disease be cured?”