Development, Aging and Regeneration Archives - Page 2 of 3 - Sanford Burnham Prebys
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Researchers resolve longstanding issue of components needed to regenerate muscle

Authorsgammon
Date

February 9, 2016

Researchers at SBP have conclusively identified the protein complex that controls the genes needed to repair skeletal muscle. The discovery clears up deep-rooted conflicting data and will now help streamline efforts towards boosting stem cell-mediated muscle regeneration. Such strategies could treat muscle degenerative diseases such as muscular dystrophies, and those associated with aging and cancer. Continue reading “Researchers resolve longstanding issue of components needed to regenerate muscle”

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SBP’s 37th Annual Symposium is around the corner

Authorsgammon
Date

October 21, 2015

This year’s Annual SBP Symposium theme is Aging and Regeneration. The line-up of distinguished speakers will cover topics from stem cell renewal, selective autophagy, and drugs that stop the aging process. Continue reading “SBP’s 37th Annual Symposium is around the corner”

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Unraveling the mystery of muscle regeneration could lead to effective treatment for muscular dystrophies

Authorsgammon
Date

September 22, 2015

By shedding light on the distinct functions of a protein complex that controls the formation of skeletal muscle tissue, SBP researchers could pave the way for the development of novel therapies for neuromuscular diseases.

Continue reading “Unraveling the mystery of muscle regeneration could lead to effective treatment for muscular dystrophies”

Institute News

Hearts build new muscle with this simple protein patch

Authorsgammon
Date

September 15, 2015

An international team of researchers has identified a protein that helps heart muscle cells regenerate after a heart attack. Researchers also showed that a patch loaded with the protein and placed inside the heart improved cardiac function and survival rates after a heart attack in mice and pigs. Continue reading “Hearts build new muscle with this simple protein patch”

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Discovery of new role of SOX2 protein sheds light on neurogenesis in the adult brain

Authorsgammon
Date

April 21, 2015

 

Newborn neurons generated from neural progenitor cells in a brain region called the hippocampus play an important role in learning and memory in adults. However, the molecular mechanisms that control this neurogenesis process have not been fully understood. Sanford-Burnham researchers recently shed new light on this question by discovering a key role of a protein called SOX2 in neuronal development. As reported online in Proceedings of the National Academy of Sciences, SOX2 promotes the activation of genes involved in differentiation, enabling neural progenitor cells to turn into mature neurons in the brains of adult mice. Continue reading “Discovery of new role of SOX2 protein sheds light on neurogenesis in the adult brain”

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Discovering a missing link between obesity and heart disease

AuthorGuest Blogger
Date

March 5, 2015

This post was written by Janelle Weaver, PhD, a freelance writer

Heart disease is the number one killer in the United States and a major cause of disability. One major risk factor is obesity, which itself has undergone a dramatic increase in prevalence in the United States over the past 20 years and now affects more than one-third of adults. A major challenge in developing targeted drugs for diet-induced heart disease is to understand how molecular and genetic changes trigger metabolic imbalances that ultimately impair heart function. Continue reading “Discovering a missing link between obesity and heart disease”

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Stem cells grow new hair – Arabic translation

Authorsgammon
Date

January 27, 2015

“دراسة جديدة لنمو الشعر”

في دراسة جديدة، إستخدم الباحثون في معهد سان- برونهام الخلايا الجذعه المحفزة1 في جسم الإنسان لتعمل على توليد ونمو الشعر الجديد. وتمثل هذه الدراسة خطوة أولى نحو تطوير علاج عن طريق الخلايا الجذعية للأشخاص الذين يعانون من مشكلة فغداً الشعر “الصلع” .في الولايات المتحدة وحدها، يعاني أكثر من 40 مليون رجل و 21 مليون إمرأة من مشكلة فقدان الشعر، ولقد تم نشر هذا البحث على الإنترنت في بلوس وان. 

تبرعكم سوف يصنع الفرق الرجاء التبرع للدكتور ألكسي للمضي قدما في هذا الإنجاز.

“لقد قمنا بتطوير طريقة إستخدام الخلايا الجذعية المحفزه لخلق خلية جديدة قادرة على بدء نمو الشعر عند الإنسان”. و قال ألكسي ترسكي و هو دكتور أستاذ مشارك في معهد التنميه، والشيخوخة و برامج التجديد ” طريقة إستعمال الخلايا الجذعية توفر مصدرا غير محدود من الخلايا من المريض لعملية زراعة الشعر وهي ليست محدودة كالطرق المستعملة حالياً عن طريق إستخدام ونزع بصيلات الشعر المتواجدة من الأصل. طور فريق البحث نظام يعمل على تمايز الخلايا الجذعية المحفزة عند الإنسان لتصبح وتتحول إلى خلايا جلدية حليمة. هذه الخلايا الجلدية تعد خلايا فريده من نوعها وتعمل على تنظيم تشكيل بصيلات الشعر و دورة نموه. هذه الخلايا الجلدية لا تعد مناسبة لنمو الشعر من تلقاء نفسها لأنها لا تتوفر بالكميات المطلوبة وتفقد قدرتها بسرعة على حث تشكيل بصيلات الشعر بدون عمله التمايز مع الخلايا الجذعية. 

عند البالغين، هذه الخلايا الجلدية يمكن تضخيمها خارج الجسم، وأنها سرعان ما تفقد خصائصها في عملية تحفيز الشعر”.يقول الدكتور ألكسي “لقد قمنا بإبتكار نظام يعمل لدفع الخليا الجذعية المحفزه عند الإنسان لتتمايز أو تتحول إلى خلايا جلدية حليمة، وقد أكد نجاح التجربة حيث أكد على قدرة هذه الخلايا على حث نمو الشعر عند زرعها عند الفئران”. خطوتنا التاليه هي زراعة الخلايا الجذعية المحفزة عند الإنسان مرة أخرى إلى جسم الإنسان، و نحن حالياً نسعى إلى شركات لتنفيذ الخطوة الأخيرة”. 

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Stem cells grow new hair – Chinese translation

Authorsgammon
Date

January 27, 2015

用干细胞促生毛发

在一项新的研究中,桑福德 – 伯纳姆的研究人员利用人类多能干细胞促生出新的头发。该研究代表了以细胞为基础的治疗人类脱发的第一步。仅在美国,就有超过4000万男性和21万女性有着脱发困扰。这项研究在PLOS ONE在线发表。 

您的资助很重要。请帮助捷列克博士继续这项研究!

“我们已开发出一种使用人类多能干细胞的方法,来创造能够引发人体毛发生长的新的细胞。该方法相对于目前那种依赖于将毛囊从头的一个部位移植到另一个部位的方法有显着的改善,”阿列克谢-捷列克博士说。身为桑福德 – 伯纳姆的研究院发展、老化、再生项目副教授的捷列克博士还指出:“我们的干细胞的方法为移植提供了无限多的来自病人的细胞源,而不受现有的毛囊的限制。” 

该研究小组开发了促使多能干细胞成为真皮毛乳头细胞的程序。真皮毛乳头细胞是一种调节毛囊形成和生长周期的独特细胞。如果只靠本身的话,毛乳头细胞并不适合于头发移植,原因是:它们的采集量不够,而且在采集后便很快失去其诱导毛囊形成的能力。 

“对成人来说,真皮毛乳头细胞不易在体外扩增,而且会很快失去它们的生发功能,”捷列克博士说。他还说:“我们开发了一个驱动人类多能干细胞分化为毛乳头细胞的程序,并通过移植到小鼠身上的实验证实了它们的生发能力。” 

“我们的下一个步骤是将那些由人类多能干细胞衍生出的人类真皮毛乳头细胞移植回人体。目前,我们正在寻求合作伙伴来实现这最后一步。” 

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Using stem cells to grow new hair

Authorsgammon
Date

January 27, 2015

In a new study, Sanford-Burnham researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. The research was published online in PLOS ONE.

“We have developed a method using human pluripotent stem cells to create new cells capable of initiating human hair growth. The method is a marked improvement over current methods that rely on transplanting existing hair follicles from one part of the head to another,” said Alexey Terskikh, PhD, associate professor in the Development, Aging, and Regeneration Program. “Our stem cell method provides an unlimited source of cells from the patient for transplantation and isn’t limited by the availability of existing hair follicles.”

The research team developed a protocol that coaxed human pluripotent stem cells to become dermal papilla cells. They are a unique population of cells that regulate hair-follicle formation and growth cycle. Human dermal papilla cells on their own are not suitable for hair transplants because they cannot be obtained in necessary amounts and rapidly lose their ability to induce hair-follicle formation in culture.

“In adults, dermal papilla cells cannot be readily amplified outside of the body and they quickly lose their hair-inducing properties,” said Terskikh. “We developed a protocol to drive human pluripotent stem cells to differentiate into dermal papilla cells and confirmed their ability to induce hair growth when transplanted into mice.”

“Our next step is to transplant human dermal papilla cells derived from human pluripotent stem cells back into human subjects,” said Terskikh. “We are currently seeking partnerships to implement this final step.”

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Newly discovered cell stress pathway could hold therapeutic promise for diverse diseases

AuthorGuest Blogger
Date

January 5, 2015

This post was written by Janelle Weaver, PhD, a freelance writer.

When cells are faced with unfavorable environmental conditions, such as limited nutrient availability, the activation of adaptive stress responses can help protect them against damage or death. For example, stressed cells can maintain sufficient energy levels for survival by degrading and recycling unnecessary or dysfunctional cellular components. This survival mechanism, known as autophagy (literally, ‘self-digestion’), also plays key roles in a variety of biological processes such as development and aging, and is often perturbed in various diseases. Even though tight control of autophagy is key to survival, relatively little is known about the signaling molecules that regulate this essential process. Continue reading “Newly discovered cell stress pathway could hold therapeutic promise for diverse diseases”