Alexey Terskikh, Ph.D.

Alexey Terskikh's Research Focus

Brain Cancer, Breast Cancer, Parkinson's Disease

During development and in many adult tissues, stem cells are capable of self-renewal or differentiation depending on the extrinsic signals provided by the surrounding microenvironment (e.g., the stem cell niche). Many cancers are thought to be maintained by cancer initiating cells (sometimes called cancer stem cells), which often hijack stem cell self-renewal mechanisms. The Terskikh laboratory is interested in elucidating the molecular and cellular mechanisms underlying self-renewing and differentiation decisions using neural stem cells as a model, in particularly studying how this knowledge can be used to fight cancer.

Alexey Terskikh's Bio

Alexey Terskikh earned his Ph.D. at the University of Lausanne, Switzerland in 1996, in the laboratory of Prof. J.P. Mach, where he designed a new type of high-avidity recombinant molecule called Peptabody. He received postdoctoral training with Prof. Irving Weissman at Stanford University, where he discovered a common genetic program between hematopoietic and neural stem cells. Dr. Terskikh holds an Assistant Professor position in the Brain and Mind Institute at EPFL in Lausanne, Switzerland (2002-2006) and was recruited to Sanford Burnham Prebys as Adjunct Assistant Professor in 2002 and as a full time Assistant Professor in 2006.


DAR Accessory

Publications

"Fluorescent timer": protein that changes color with time.

Terskikh A, Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P

Science 2000 Nov 24 ;290(5496):1585-8

Human ESC-derived neural crest model reveals a key role for SOX2 in sensory neurogenesis.

Cimadamore F, Fishwick K, Giusto E, Gnedeva K, Cattarossi G, Miller A, Pluchino S, Brill LM, Bronner-Fraser M, Terskikh AV

Cell Stem Cell 2011 May 6 ;8(5):538-51

SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.

Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, Terskikh AV

Proc Natl Acad Sci U S A 2015 Apr 14 ;112(15):E1936-45

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Dual function of Zika virus NS2B-NS3 protease.

Shiryaev SA, Cieplak P, Cheltsov A, Liddington RC, Terskikh AV

PLoS Pathog 2023 Nov ;19(11):e1011795

Imaging-based chromatin and epigenetic age, ImAge, quantitates aging and rejuvenation.

Alvarez-Kuglen M, Rodriguez D, Qin H, Ninomiya K, Fiengo L, Farhy C, Hsu WM, Havas A, Feng GS, Roberts AJ, Anderson RM, Serrano M, Adams PD, Sharpee TO, Terskikh AV

Res Sq 2023 Nov 7 ;

Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in "Super-Open" Conformation.

Meewan I, Shiryaev SA, Kattoula J, Huang CT, Lin V, Chuang CH, Terskikh AV, Abagyan R

Viruses 2023 Apr 30 ;15(5)

ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest.

Lin L, Pinto A, Wang L, Fukatsu K, Yin Y, Bamforth SD, Bronner ME, Evans SM, Nie S, Anderson RH, Terskikh AV, Grossfeld PD

Hum Mol Genet 2022 Dec 16 ;31(24):4217-4227

A Zika virus mutation enhances transmission potential and confers escape from protective dengue virus immunity.

Regla-Nava JA, Wang YT, Fontes-Garfias CR, Liu Y, Syed T, Susantono M, Gonzalez A, Viramontes KM, Verma SK, Kim K, Landeras-Bueno S, Huang CT, Prigozhin DM, Gleeson JG, Terskikh AV, Shi PY, Shresta S

Cell Rep 2022 Apr 12 ;39(2):110655

High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells.

Smith AS, Ankam S, Farhy C, Fiengo L, Basa RCB, Gordon KL, Martin CT, Terskikh AV, Jordan-Sciutto KL, Price JH, McDonough PM

J Pharmacol Toxicol Methods 2022 Mar-Apr ;114:107157

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