Metabolic Disease Archives - Sanford Burnham Prebys
Institute News

Aspiring scientists tackle big data at Sanford Burnham Prebys Medical Discovery Institute

AuthorGuest Blogger
Date

June 24, 2016

Growing up, Courtney Astore was inquisitive about science and technology. So when she had the opportunity to participate in middle school science fairs, she jumped at the chance. In high school, Astore’s research in behavioral and social science, medicine and elaborate statistical algorithms led to her being a finalist at the Intel International Science and Engineering Fair three times.

Today, as an incoming sophomore at the University of Central Florida (UCF), Astore is majoring in Biotechnology with a focus on Bioinformatics. Together, with her lifelong friend Rebecca Elsishans at the University of Florida, she plans to launch a start-up company called Enasci-x that will use genetic analysis to aid in vaccine development.

Executives at UCF’s business incubator contacted Leslie Molony, PhD, senior director of Business Development for Sanford Burnham Prebys Medical Discovery Institute’s (SBP)  Lake Nona campus to inquire about providing  training to aspiring scientists enrolled in the National Science Foundation- iCorps™ funded  LaunchPad program.

The LaunchPad program fosters entrepreneurial research designed to help the commercialization of technology. Molony guided Astore and Elsishans in the biological science and business aspects of forming a start-up for their first product-in-development called Genes4Vaccines.

Her students received guidance on a top-level list of ‘how-to’s’

  • how to understand protein structures
  • how to generate data that can lead to new drug discovery
  • how to define new products and commercialize them
  • how to develop business plans and ‘pitching’ strategies

 

“Courtney and Rebecca are phenomenal young women who are very eager to understand how the medical research process—vaccine discovery–can lead to commercial products,” said Molony.  “They have great potential to become software service providers, or to use their talents to discover new vaccine targets that may lead to partnerships with pharmaceutical companies.”

“In terms of where we are today and how we’ve been able to map out what we need to do, we couldn’t have done any of this without Dr. Molony,” said Astore. “Her drug discovery background and business development expertise have opened our eyes to the potential of what we can accomplish, and what we need to do to get there. We know our next big steps are to finalize our minimum value product, get data validation in the lab and then attract investors.”

Big data for medical research, adds Molony, is a growing niche in the field of infectious disease where vaccine and therapy needs arise quickly and unexpectedly.

To augment her student’s training, she connected Astore with Fraydoon Rastinejad, PhD, professor in SBP’s Center for Metabolic Origins of Disease at Lake Nona who offered her a summer internship where she’ll be collecting data and analyzing human disease databases.

“Dr. Rastinejad is one of the most renowned researchers in the field, and I’m honored to have the opportunity to work with him.  My internship will give me a deeper base of scientific knowledge to advance my research,” said Astore. “To work hands-on in his lab, analyzing data that recognizes patterns and clues to disease development is a dream come true.”

This post was written by Jackie Kelvington

Related:
Genes4Vaccines – UCF I-Corps

 

Institute News

Why the “Biggest Losers” don’t win

AuthorJessica Moore
Date

May 12, 2016

Following a recent publication on the long-term effects of participation in TV’s “Biggest Loser” competition, Steven Smith, MD, professor in SBP’s Integrative Metabolism Program and director of the Translational Research Institute for Metabolism and Diabetes at Florida Hospital, was interviewed by NBC WESH TV Orlando reporter Amanda Ober. Smith explained why nearly all of the “Biggest Losers” regained large proportions of the weight they had lost, and sometimes even more. Continue reading “Why the “Biggest Losers” don’t win”

Institute News

SBP’s Lake Nona campus to host metabolomics symposium

AuthorJessica Moore
Date

April 29, 2016

The annual Southeast Center for Integrated Metabolomics (SECIM) symposium will be held at SBP’s Lake Nona Campus next week (May 3-4). SECIM, a collaboration between SBP and the University of Florida, is one of six federally funded centers that provide cutting-edge metabolite fingerprinting capabilities to the research community. Metabolites are small molecules in the body that populate the complex web of metabolic pathways. Metabolomics is a relatively new field that uses sophisticated technologies to detect hundreds to thousands of metabolites in biological samples. A metabolite profile can serve as a signature of health, disease or drug action. Continue reading “SBP’s Lake Nona campus to host metabolomics symposium”

Institute News

Doug Lewandowski, PhD, elected as a Fellow of the American Association for the Advancement of Science

AuthorJessica Moore
Date

April 28, 2016

The director of Translational Cardiovascular Research at SBP’s Lake Nona campus was recently named a Fellow of the American Association for the Advancement of Science (AAAS). E. Douglas Lewandowski, PhD, was one of 33 scientists selected to become a AAAS fellow in the Section on Medical Sciences, recognizing his “distinguished contributions to fundamental aspects of cardiac metabolism and their implications for heart disease.” Continue reading “Doug Lewandowski, PhD, elected as a Fellow of the American Association for the Advancement of Science”

Institute News

How your organs ‘taste’ sugar

Authorjmoore
Date

April 18, 2016

You might be surprised to learn that the sensors for sweet-tasting molecules aren’t located only on your tongue—they’re also found in the gut, pancreas, fat tissue, and muscle. And new research from the laboratory of George Kyriazis, PhD, assistant professor in the Integrative Metabolism Program at Lake Nona, indicates just how important these sweet taste receptors are in regulating metabolism. Continue reading “How your organs ‘taste’ sugar”

Institute News

Generating good fat by pushing the right buttons

Authorjmoore
Date

March 30, 2016

Researchers at SBP have identified a protein complex that is required for conversion of “bad” white fat to “good” brown fat. The findings, published in the Journal of Clinical Investigation, could help treat metabolic disorders such as obesity. Continue reading “Generating good fat by pushing the right buttons”

Institute News

New links between heart hormones, obesity, and diabetes

AuthorGuest Blogger
Date

February 17, 2016

New research from SBP’s Sheila Collins, PhD, and Richard Pratley, MD, has revealed an important relationship between proteins secreted by the heart and obesity, glucose intolerance, and insulin resistance. The findings, published in Obesity, offer a new approach to treating metabolic disorders, including type 2 diabetes, by targeting the pathway that controls the proteins’ concentration in the blood. Continue reading “New links between heart hormones, obesity, and diabetes”

Institute News

5 things you need to know about Thanksgiving and your metabolism

Authorsgammon
Date

November 25, 2015

Thanksgiving Day is fast approaching. While you may want to celebrate with your friends and family, you should think twice before you stuff yourself like a turkey. Overeating has been linked with metabolic disorders including diabetes, obesity, and heart disease.

Read further to learn about some of the effects of overeating, and the research at SBP aimed to find new ways to treat metabolic disorders.

  1. Although people think the average weight gain over the holidays is five pounds, it’s in fact only one pound. But most people don’t lose that pound after the holidays, and that probably contributes to our increasing body weight as we age.
  2. For patients with type 2 diabetes, eating during the winter holidays can lead to a substantial increase in your average blood sugar. The effects might not be reversed in the summer and autumn months, so be mindful of your food intake.
  3. Research has shown a link between a brain hormone called glucagon like peptide-1 (GLP-1), and overeating. GLP-1 is supposed to let our brains know when we are full. Deficiencies in the hormone may the cause us to consume more food than we need.
  4. The risk of a heart attack jumps four times in the two hours after a large meal. Eating in excess causes the stomach and intestines to work harder, challenging the heart.
  5. According to the Calorie Control Council, the average American may consume more than 4,500 calories during a traditional Thanksgiving dinner. Although the rule of thumb is that there are 3,500 calories in a pound, new research suggests you have to burn 7,000 calories for each pound of fat you want to get rid of.

To learn more about what SBP is doing to treat metabolic conditions, see these stories.

 

Can your heart prevent diabetes?

Anti-oxidant rich diet could stave off type 2 diabetes

Potential drug targets could improve treatment of vascular disease in diabetic patients

The hungry heart

Exercise following bariatric surgery provides health benefits

Ketogenesis prevents fatty liver disease

Institute News

Scientists solve structure of important protein for tumor growth

Authorsgammon
Date

August 5, 2015

In a collaborative study between SBP and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors (HIFs), important regulators of a tumor’s response to low oxygen (hyopoxia). The findings, published today in the journal Nature, open the door to search for new drugs to treat tumors by cutting off their supply of oxygen and nutrients. Continue reading “Scientists solve structure of important protein for tumor growth”

Institute News

Meet our faculty: George Kyriazis, PhD

Authorpbartosch
Date

April 21, 2015

 

A few weeks ago, we announced that our former Sanford-Burnham postdoctoral fellow, George Kyriazis, PhD, was joining the Institute’s Orlando campus as a faculty member. We sat down with George last week to discuss his background, research interest, and life outside of work. Continue reading “Meet our faculty: George Kyriazis, PhD”